The serotonin hypothesis of aggression revisited

Clinical Psychology Review

Volumn 17, Issue 6, 1997, Pages 651-665

  Berman, Mitchell E ^a   Tracy, Joseph I ^b   Coccaro, Emil F ^b  

^a UNIVERSITY OF SOUTHERN MISSISSIPPI   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN;

AGGRESSION; ANIMAL; BIOLOGICAL MODEL; COGNITION; HUMAN; INHIBITION (PSYCHOLOGY); IRRITABILITY; METHODOLOGY; PHYSIOLOGY; PRIMATE; PSYCHOMETRY; REVIEW; STANDARD;

AGGRESSION; ANIMALS; COGNITION; HUMANS; INHIBITION (PSYCHOLOGY); IRRITABLE MOOD; MODELS, BIOLOGICAL; PRIMATES; PSYCHOMETRICS; RESEARCH DESIGN; SEROTONIN;

EID: 0031299109     PISSN: 02727358     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-7358(97)00039-1     Document Type: Article

References (52)

1. Archer, J. (1991). The influence of testosterone on human aggression. British Journal of Psychology, 82, 1-28.
2. Berkowitz, L. (1993). Aggression: Its causes, consequences, and control. New York: McGraw-Hill.
3. Berman, M. E., Kavoussi, R. J., & Coccaro, E. F. (in press). Neurotransmitter correlates of human aggression. In D. M Stoff, J. Breiling, & J. Maser (Eds.), Handbook of antisocial behavior. New York: John Wiley & Sons.
4. Biaggio, M. K., & Maiuro, R. D. (1985). Recent advance in anger assessment. In C. D. Spielberger & J. N. Butcher (Eds.), Advances in personality assessment (Vol. 5, pp. 71-111). Hillsdale, NJ: Lawrence Erlbaum Associates.
5. Boring, E. G. (1950). A history of experimental psychology (2nd ed.). Englewood Cliffs, NJ: Prentice-Hall.
6. Bornstein, P. H., Weisser, C. E., & Balleweg, B. J. ( 1985). Anger and violent behavior. In M. Hersen & A.S. Bellack (Eds.), Handbook of clinical behavior therapy with adults (pp. 603-629). New York: Plenum Press.
7. Brown G. L., Ebert M. H., Goyer P. F., Jimerson D. C., Klein W. J., Bunney W. E., & Goodwin, F. K. (1982). Aggression, suicide, and serotonin: relationships to CSF amine metabolites. American Journal of Psychiatry, 139, 741-746.
8. Brown G. L., Goodwin F. K., Ballenger J. C., Goyer P. F., & Major, L. F. (1979). Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research, 1, 131-139.
9. Buydens-Branchey, L., Branchey, M. H., Noumair, D., & Lieber, C. S. (1989). Age of alcoholism onset: II. Relationship to susceptibility to serotonin precursor availability. Archives of General Psychiatry, 46, 231-236.
10. Chamberlain, B., Ervin, F. R., Pihl, R. O., & Young, S. N. (1987). The effect of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacology, Biochemistry, & Behavior, 28, 503-510.
11. Cherek, D. R., Spiga, R., & Creson, D. L. (1995). Acute effects of eltoprazine on aggressive and point-maintained responding of normal male participants: Phase I study. Experimental and Clinical Psychopharmacology, 3, 287-293.
12. Cherek, D. R., Spiga, R., Steinberg, J. L., & Kelly, T. H. (1990). Human aggressive responses maintained by avoidance or escape from point loss. Journal of Experimental Analysis of Behavior, 53, 293-304.
13. Cleare, A. J., & Bond, A. J. (1995). The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology, 118, 72-81.
14. Coccaro, E. F. (1989). Central serotonin and impulsive aggression. British Journal of Psychiatry, 155(Suppl. 8), 52-62.
15. Coccaro, E. F. (1992). Impulsive aggression and central serotonergic system function in humans: An example of a dimensional brain-behavior relationship. International Clinical Psychopharmacology, 7, 3-12.
16. Coccaro, E. F., Berman, M., Kavoussi, R. J., & Hauger, R. D. (1996). Relationship of prolactin response to d-Fenfluramine to behavioral and questionnaire assessments of aggression in personality disordered males. Biological Psychiatry, 40, 157-164.
17. Coccaro, E. F., & Kavoussi, R. J. (1994). Neuropsychopharmacologic challenge in biological psychiatry, Clinical Chemistry, 40, 319-327.
18. Coccaro, E. F., & Kavoussi, R. J. (in press). Fluoxetine reduces impulsive aggressive behavior in personality-disordered subjects: Results from a double-blind placebo-controlled trial. Archives of Central Psychiatry.
19. Coccaro, E. F., Kavoussi, R. J., Sheline, Y. I., Lish, J. D., & Csernansky, J. G (1996). Impulsive aggression in personality disorder correlates with tritiated paroxetine binding I the platelet. Archives of General Psychiatry, 53, 531-536.
20. Coccaro, E. F., Siever, L. J., Klar, H. M., Maurer, G., Cochrane, K., Cooper, T. B., Mohs, R. C., & Davis, K. L. (1989). Serotonergic studies in patients with affective and personality disorders: Correlates with suicidal and impulsive aggressive behavior. Archives of General Psychiatry, 46, 587-599.
21. Galvin, M., Shekhar, A., Simon, J., Stilwell, B., Ten Eyck, R., Laite, G., Karwisch, G., & Blix, S. (1991). Low dopamine-beta-hydroxylase: A biological sequela of abuse and neglect? Psychiatry Research, 39, 1-11.
22. Gardner, D. L., Lucas, P. B., & Cowdry, R. W. (1990). CSF Metabolites in borderline personality disorder compared with normal controls. Biological Psychiatry, 28, 247-254.
23. Geen, R. G. (1990). Human aggression. Pacific Grove, CA: Brooks/Cole.
24. Gerra, G., Caccavari, R., Delsignore, R., Passeri, M., Fertonani Affini, G., Maestri, D., Monica, C., & Brambilla, F. (1993). Parental divorce and neuroendocrine changes in adolescents. Acta Psychiatrica, Scandinavica, 87, 350-354.
25. Giancola, P. R., & Chermack, S. T. (in press). Construct validity of laboratory aggression paradigms: A response to Tedeschi and Quigley (1996). Aggression and Violent Behavior.
26. Halperin, J. M., Sharma, V., Siever, L. J., Schwartz, S. T., Matier, K., Wornell, G., & Newcorn, J. H. (1994). Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. American Journal of Psychiatry, 151, 243-248.
27. Higley, J. D., Suomi, S. J., & Linnoila, M. (1991). CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology, 103, 551-556.
28. Kraemer, G. W., Ebert, M. H., Schmidt, D. E., & McKinney, W. T. (1989). A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys. Neuropsychopharmacology, 2, 175-189.
29. Kruesi, M. J., Rapoport, J. L., Hamburger, S., Hibbs, E., & Potter, W. Z. (1990). Cerebrospinal fluid monamine metabolites, aggression and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry, 47, 419-426.
30. Lidberg, L., Tuck, J.R., Åsberg, M., Scalia-Tomba, G.P., & Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230-236.
31. Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B., Linnoila, M. (1991). Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry, 48, 437-441.
32. Linnoila, V. M. I., & Virkkunen, M. (1992). Aggression, suicidality, and serotonin. Journal of Clinical Psychiatry, 53(Suppl. 10), 46-51.
33. Linnoila, M., Virkkunen, M., Schwannian, M., Nuutila, A., Rimon, R., & Goodwin F. K. (1983). Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from non-impulsive violent behavior. Life Sciences, 33, 2609-2614.
34. Marks, P. C., O'Brien, M., & Paxinos, G. (1977). 5,7-DHT-induced muricide: Inhibition as a result of exposure of rats to mice. Brain Research, 135, 383-388.
35. Moeller, F. G., Steinberg, J. L., Petty, F., Fulton, M., Cherek, D. R., Kramer, G., & Garver, D. L. (1994). Serotonin in impulsive/aggressive behavior in cocaine dependent subjects. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 18, 1027-1035.
36. O'Keane, V., Moloney, E., O'Neill, H., O'Connor, A., Smith, C., & Dinan, T. G. (1992). Blunted prolactin responses to d-Fenfluramine in sociopathy: Evidence for subsensitivity of central serotonergic function. British Journal of Psychiatry, 160, 643-646.
37. Pihl, R. O., Young, S., Harden, P., Plotnick, S., Chamberlain, B., & Ervin, F. R. (1995). Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology, 119, 353-360.
38. Pine, D. S., Coplan, J. D., Wasserman, G. A., Miller, L. S., Fried, J. E., Davies, M., Cooper, T. B., Greenhill, L., Shaffer, D., & Parsons, D. (in press). Neuroendocrine response to d,1-fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing. Archives of General Psychiatry.
39. Raleigh, M. J., McGuire, M. T., Brammer, G. L., Pollack, D. B., & Yuwiler, A. (1991). Serotonergic mechanisms promote dominance acquisition in adult vervet monkeys. Brain Research, 559, 181-190.
40. Scott, J. P. (1992). Aggression: Functions and control in social systems. Aggressive Behavior, 18, 1-20.
41. Simeon, D., Stanley, B., Frances, A., Mann, J. J., Winchel, R., & Stanley, M. (1992). Self-mutilation in personality disorders: Psychological and biological correlates. American Journal of Psychiatry, 149, 221-226.
42. Smith, S. E., Pihl, R. O., Young, S. N., & Ervin, F. R. (1986). Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggressive Behavior, 12, 393-407.
43. Spoont, M. R. (1992). Modulatory role of serotonin in neural information processing: Implications for human psychopathology. Psychological Bulletin, 112, 330-350.
44. Stoff, D. M., Pasatiempo, A. P., Yeung, J., Cooper, T. B., Bridger, W. H., & Rabinovich, H. (1992). Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Research, 43, 263-276.
45. Taylor, S. P. (1967). Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. Journal of Personality, 35, 297-310.
46. Tecott, L. H., Maricq, A. V., & Julius, D. (1993). Nervous system distribution of the serotonin 5-HT3 receptor mRNA, Proceedings of the National Academy of Science, 90, 1430-1434.
47. van Praag, H. N., Asnis, G. M., Kahn, R. S. Brown, S. I., Korn, M., Harkavy Friedman, J. M., & Wetzler, S. (1990). Monoamines and abnormal behaviour: A multi-aminergic perspective. British Journal of Psychiatry, 157, 723-734.
48. Virkkunen, M., Kallio, E., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S., & Linnoila, M. (1994). Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry, 51, 28-33.
49. Virkkunen, M., Nuutila, A., Goodwin, F. K., & Linnoila, M. (1987). Cerebrospinal fluid monoamine metabolite levels in male arsonists. Archives of General Psychiatry, 44, 241-247.
50. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., Bissette, G., Kalogeras, K., Karonen, S., & Linnoila, M. (1994). CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry, 51, 20-27.
51. Young, S. N., Ervin, F. R., Pihl, R. O., & Finn, P. (1989). Biochemical aspects of tryptopham depletion in primates. Psychopharmacology, 98, 508-511.
52. Young, S. N., & Gauthier, S. (1981). Effect of tryptophan administration on tryptophan, 5-hydroxyindolacetic acid, and indolacetic acid in human lumbar and cisternal cerebrospinal fluid. Journal of Neurology, Neurosurgery and Psychiatry, 44, 323-327.