Identification of candidate biomarkers for early detection of human lung squamous cell cancer by quantitative proteomics

Molecular and Cellular Proteomics

Volumn 11, Issue 6, 2012, Pages

  Zeng, Gu Qing ^a,b   Zhang, Pang Fei ^a   Deng, Xingming ^d   Yu, Feng Lei ^c   Li, Cui ^a   Xu, Yan ^a   Yi, Hong ^a   Li, Mao Yu ^a   Hu, Rong ^a   Zuo, Jian Hong ^a   Li, Xin Hui ^a   Wan, Xun Xun ^a   Qu, Jia Quan ^a   He, Qiu Yan ^a   Li, Jian Huang ^a   Ye, Xu ^a   Chen, Yu ^a   Li, Jiao Yang ^a   Xiao, Zhi Qiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; BIOLOGICAL MARKER; CREATINE KINASE BB; GLUTATHIONE TRANSFERASE P1; HEAT SHOCK PROTEIN 27; PROTEIN TAG; TUMOR MARKER; GSTP1 PROTEIN, HUMAN; HSPB1 PROTEIN, HUMAN;

ANALYTICAL EQUIPMENT; ARTICLE; BRONCHUS MUCOSA; CANCER CELL CULTURE; CANCER DIAGNOSIS; CARCINOMA IN SITU; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EARLY DIAGNOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL METAPLASIA; WESTERN BLOTTING; AMINO ACID SEQUENCE; BRONCHUS; CELL LINE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLUSTER ANALYSIS; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; LUNG TUMOR; METABOLISM; MOLECULAR GENETICS; NONPARAMETRIC TEST; PATHOLOGY; RECEIVER OPERATING CHARACTERISTIC; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; BRONCHI; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; CREATINE KINASE, BB FORM; EARLY DETECTION OF CANCER; EPITHELIAL CELLS; GENE EXPRESSION; GLUTATHIONE S-TRANSFERASE PI; HSP27 HEAT-SHOCK PROTEINS; HUMANS; LASER CAPTURE MICRODISSECTION; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; NEOPLASMS, SQUAMOUS CELL; PROTEOMICS; ROC CURVE; STATISTICS, NONPARAMETRIC; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL;

EID: 84862305020     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.013946     Document Type: Article

References (67)

1. Parkin, D. M. (2001) Global cancer statistics in the year 2000. Lancet Oncol. 2, 533-543
2. Yang, L., Parkin, D. M., Li, L. D., Chen, Y. D., and Bray, F. (2004) Estimation and projection of the national profile of cancer mortality in China: 1991-2005. Br. J. Cancer 90, 2157-2166
3. Howe, H. L., Wingo, P. A., Thun, M. J., Ries, L. A., Rosenberg, H. M., Feigal, E. G., and Edwards, B. K. (2001) Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends. J. Natl. Cancer Inst. 93, 824-842
4. Greenberg, A. K., Yee, H., and Rom, W. N. (2002) Preneoplastic lesions of the lung. Respir Res. 3, 20-21
5. Auerbach, O., Hammond, E. C., and Garfinkel L. (1979) Changes in bronchial epithelium in relation to cigarette smoking 1955-1966 VS 1970-1977. N. Engl. J. Med. 300, 381-385
6. Deng, B., Ye, N., Luo, G., Chen, X., and Wang, Y. (2005) Proteomics analysis of stage-specific proteins expressed in human squamous cell lung carcinoma tissues. Cancer Biomark. 1, 279-286
7. Planque, C., Kulasingam, V., Smith, C. R., Reckamp, K., Goodglick, L., and Diamandis, E.P. (2009) Identification of five candidate lung cancer biomarkers by proteomics analysis of conditioned media of four lung cancer cell lines. Mol. Cell. Proteomics 8, 2746-2758
8. Patz, E. F., Jr., Campa, M. J., Gottlin, E. B., Kusmartseva, I., Guan, X. R., and Herndon, J. E. 2nd2. (2007) Panel of serum biomarkers for the diagnosis of lung cancer. J. Clin. Oncol. 25, 5578-5583
9. Zeng, X., Hood, B. L., Sun, M., Conrads, T. P., Day, R. S., Weissfeld, J. L., Siegfried, J. M., and Bigbee, W. L. (2010) Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometry. J. Proteome Res. 9, 6440-6449
10. Li, C., Xiao, Z., Chen, Z., Zhang, X., Li, J., Wu, X., Li, X., Yi, H., Li, M., Zhu, G., Liang, S. (2006) Proteome analysis of human lung squamous carcinoma. Proteomics 6, 547-558
11. Yang, F., Xiao, Z. Q., Zhang, X. Z., Li, C., Zhang, P. F., Li, M. Y., Chen, Y., Zhu, G. Q., Sun, Y., Liu, Y. F., and Chen, Z. C. (2007) Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. J. Proteome Res. 6, 751-758
12. Li, D. J., Deng, G., Xiao, Z. Q., Yao, H. X., Li, C., Peng,. F., Li, M. Y., Zhang, P. F., Chen, Y. H., and Chen, Z. C. (2009) Identificating 14-3-3 sigma as a lymph node metastasis-related protein in human lung squamous carcinoma. Cancer Lett. 279, 65-73
13. Zhang, X. Z., Xiao, Z. F., Li, C., Xiao, Z. Q., Yang, F., Li, D. J., Li, M. Y., Li, F., and Chen, Z. C. (2009) Triosephosphate isomerase and peroxiredoxin 6, two novel serum markers for human lung squamous cell carcinoma. Cancer Sci. 100, 2396-2401
14. Brichory, F., Beer, D., Le Naour, F., Giordano, T., and Hanash, S. (2001) Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer. Cancer Res. 61, 7908-7912
15. Ocak, S., Chaurand, P., and Massion, P. P. (2009) Mass spectrometry-based proteomic profiling of lung cancer. Proc. Am. Thorac. Soc. 6, 159-170
16. Hassanein, M., Rahman, J. S., Chaurand, P., and Massion, P. P. (2011) Advances in proteomic strategies toward the early detection of lung cancer. Proc. Am. Thorac. Soc. 8, 183-188
17. Bharti, A., Ma, P. C., and Salgia, R. (2007) Biomarker discovery in lung cancer-promises and challenges of clinical proteomics. Mass. Spectrom. Rev. 26, 451-466
18. Rahman, S. M., Shyr, Y., Yildiz, P. B., Gonzalez, A. L., Li, H., Zhang, X., Chaurand, P., Yanagisawa, K., Slovis, B. S., Miller, R. F., Ninan, M., Miller, Y. E., Franklin, W. A., Caprioli, R. M., Carbone, D. P., and Massion, P.P. (2005) Proteomic patterns of preinvasive bronchial lesions. Am. J. Respir. Crit. Care Med. 172, 1556-1562
19. Emmert-Buck, M. R., Bonner, R. F., Smith, P. D., Chuaqui, R. F., Zhuang, Z., Goldstein, S. R., Weiss, R. A., and Liotta, L.A. (1996) Laser capture microdissection. Science 274, 998-1001
20. Zieske, L.R. (2006) A perspective on the use of iTRAQ reagent technology for protein complex and profiling studies. J. Exp. Bot. 57, 1501-1508
21. Ralhan, R., Desouza, L. V., Matta, A., Chandra, Tripathy, S., Ghanny, S., Datta, Gupta, S., Bahadur, S., and Siu, K. W. (2008) Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. Mol. Cell. Proteomics 7, 1162-1173
22. DeSouza, L. V., Grigull, J., Ghanny, S., Dubé, V., Romaschin, A. D., Colgan, T. J., and Siu, K.W. (2007) Endometrial carcinoma biomarker discovery and verification using differentially tagged clinical samples with multidimensional liquid chromatography and tandem mass spectrometry. Mol. Cell. Proteomics 6, 1170-1182
23. Pierce, A., Unwin, R. D., Evans, C. A., Griffiths, S., Carney, L., Zhang, L., Jaworska, E., Lee, C. F., Blinco, D., Okoniewski, M. J., Miller, C. J., Bitton, D. A., Spooncer, E., and Whetton, A. D. (2008) Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases. Mol. Cell. Proteomics 7, 853-863
24. Travis, W. D., Colby, T. V., Corrin, B., Shimosato, Y., and Brambilla E. (1999) Histological typing of lung and pleural tumours, 3rd Edn., Springer-Verlag, Berlin
25. Cheng, A. L., Huang, W. G., Chen, Z. C., Peng, F., Zhang, P. F., Li, M. Y., Li, F., Li, J. L., Li, C., Yi, H., Yi, B., and Xiao, Z. Q. (2008) Identification of novel nasopharyngeal carcinoma biomarkers by laser capture microdissection and proteomic analysis. Clin. Cancer Res. 14, 435-445
26. Xiao, Z., Li, G., Chen, Y., Li, M., Peng, F., Li, C., Li, F., Yu, Y., Ouyang, Y., Xiao, Z., and Chen, Z. (2010) Quantitative proteomic analysis of formalin-fixed and paraffin-embedded nasopharyngeal carcinoma using iTRAQ labeling, two-dimensional liquid chromatography, and tandem mass spectrometry. J. Histochem. Cytochem. 58, 517-527
27. Elias, J. E., and Gygi, S. P. (2007) Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat. Methods 4, 207-214
28. Feng, X. P., Yi, H., Li, M. Y., Li, X. H., Yi, B., Zhang, P. F., Li, C., Peng, F., Tang, C. E., Li, J. L., Chen, Z. C., and Xiao, Z. Q. (2010) Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics. Cancer Res. 70, 3450-3462
29. Sun, Y., Yi, H., Yang, Y., Yu, Y., Ouyang, Y., Yang, F., Xiao, Z., and Chen, Z. (2009) Functional characterization of p53 in nasopharyngeal carcinoma by stable shRNA expression. Int. J. Oncol. 34, 1017-1027
30. Dennis, G Jr., Sherman, B. T., Hosack, D. A., Yang, .J, Gao, W., Lane, H. C., and Lempicki, R. A. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4, P3
31. Hu, Z., Mellor, J., Wu, J., and DeLisi, C. (2004) VisANT: an online visualization and analysis tool for biological interaction data. BMC Bioinformatics 5, 17
32. Hu, Z., Mellor, J., Wu, J., Yamada, T., Holloway, D., and Delisi, C. (2005) VisANT: data-integrating visual framework for biological networks and modules. Nucleic Acids Res. 33, W352-357
33. Hayes, J. D., and Pulford, D. J. (1995) (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 30, 445-600
34. Sekine, I., Minna, J. D., Nishio, K., Tamura, T., and Saijo, N. (2006) A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer. J. Thorac. Oncol. 1, 31-37
35. Vlachogeorgos, G., S, Manali, E. D., Blana, E., Legaki, S., Karagiannidis, N., and Polychronopoulos, V. S., Roussos C. (2008) Placental isoform glutathione S-transferase and P-glycoprotein expression in advanced non-small cell lung cancer: association with response to treatment and survival. Cancer 114, 519-526
36. Hirano, T., Kato, H., Maeda, M., Gong, Y., Shou, Y., Nakamura, M., Maeda, J., Yashima, K., Kato, Y., Akimoto, S., Ohira, T., Tsuboi, M., and Ikeda, N. (2005) Identification of postoperative adjuvant chemotherapy responders in non-small cell lung cancer by novel biomarker. Int. J. Cancer 117, 460-468
37. Sun, N., Sun, X., Chen, B., Cheng, H., Feng, J., Cheng, L., and Lu Z. (2010) MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 65, 437-446
38. Gao, P., Yang, X., Xue, Y. W., Zhang, X. F., Wang, Y., Liu, W. J., and Wu, X. J. (2009) Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression. Cancer 115, 3222-3232
39. Cote, M. L., Chen, W., Smith, D. W., Benhamou, S., Bouchardy, C., Butkiewicz, D., Fong, K. M., Gené, M., Hirvonen, A., Kiyohara, C., Larsen, J. E., Lin, P., Raaschou-Nielsen, O., Povey, A. C., Reszka, E., Risch, A., Schneider, J., Schwartz, A. G., Sorensen, M., To-Figueras, J., Tokudome, S., Pu, Y., Yang, P., Wenzlaff, A. S., Wikman, H., and Taioli, E. (2009) Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review. Am. J. Epidemiol. 169, 802-814
40. Zienolddiny, S., Campa, D., Lind, H., Ryberg, D., Skaug, V., Stangeland, L. B., Canzian, F., and Haugen, A. (2008) A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis 29, 1164-1169
41. Hoffmann, D., Djordjevic, M. V., and Hoffmann, I. (1997) The changing cigarette. Prev. Med. 26, 427-434
42. Osada, H., and Takahashi, T. (2002) Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene 21, 7421-7434
43. Sims, P., and Grover, P. L. (1974) Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. Adv. Cancer Res. 20, 165-274
44. Baird, W. M., Hooven, L. A., Mahadevan, B. (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ. Mol. Mutagen. 45, 106-114
45. Hayes, J. D., Flanagan, J. U., and Jowsey, I. R. (2005) Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 45, 51-88
46. Reszka, E., and Wasowicz, W. (2001) Significance of genetic polymorphisms in glutathione S-transferase multigene family and lung cancer risk. Int. J. Occup. Med. Environ. Health 14, 99-113
47. Ciocca, D. R., Oesterreich, S., Chamness, G. C., McGuire, W. L., and Fuqua, S. A. (1993) Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review. J. Natl. Cancer Inst. 85, 1558-1570
48. Paul, C., Manero, F., Gonin, S., Kretz-Remy, C., Virot, S., and Arrigo, A. P. (2002) Hsp27 as a negative regulator of cytochrome C release. Mol. Cell. Biol. 22, 816-834
49. O'Callaghan-Sunol, C., Gabai, V. L., and Sherman, M. Y. (2007) Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res. 67, 11779-11788
50. Calderwood, S. K., Khaleque, M. A., Sawyer, D. B., and Ciocca, D. R. (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem. Sci. 31, 164-172
51. Kim, E. H., Lee, H. J., Lee, D. H., Bae, S., Soh, J. W., Jeoung, D., Kim, J., Cho, C. K., Lee, Y. J., and Lee, Y. S. (2007) Inhibition of heat shock protein 27-mediated resistance to DNA damaging agents by a novel PKC delta-V5 heptapeptide. Cancer Res. 67, 6333-6341
52. Garrido, C., Fromentin, A., Bonnotte, B., Favre, N., Moutet, M., Arrigo, A. P., Mehlen, P., and Solary, E. (1998) Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res. 58, 5495-5499
53. Kamada, M., So, A., Muramaki, M., Rocchi, P., Beraldi, E., and Gleave, M. (2007) Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells. Mol. Cancer Ther. 6, 299-308
54. Ciocca, D. R., and Calderwood, S. K. (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10, 86-103
55. Yao, H., Zhang, Z., Xiao, Z., Chen, Y., Li, C., Zhang, P., Li, M., Liu, Y., Guan, Y., Yu, Y., and Chen, Z. (2009) Identification of metastasis associated proteins in human lung squamous carcinoma using two-dimensional difference gel electrophoresis and laser capture microdissection. Lung Cancer 65, 41-48
56. Lomnytska, M. I., Becker, S., Bodin, I., Olsson, A., Hellman, K., Hellström, A. C., Mints, M., Hellman, U., Auer, G., and Andersson, S. (2011) Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. Br. J. Cancer 104, 110-119
57. Kapranos, N., Kominea, A., Konstantinopoulos, P. A., Savva, S., Artelaris, S., Vandoros, G., Sotiropoulou-Bonikou, G., and Papavassiliou, A. G. (2002) Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance. J. Cancer Res. Clin. Oncol. 128, 426-432
58. Lindeman, B., Skarpen, E., and Huitfeldt, H. S. (1998) Stress protein expression in rat liver during tumour promotion: induction of heat-shock protein 27 in hepatocytes exposed to 2-acetylaminofluorene. Carcinogenesis 19, 1559-1563
59. O'Neill, P. A., Shaaban, A. M., West, C. R., Dodson, A., Jarvis, C., Moore, P., Davies, M. P., Sibson, D. R., and Foster, C. S. (2004) Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27. Br. J. Cancer 90, 182-188
60. Joseph, J., Cardesa, A., and Carreras, J. (1997) Creatine kinase activity and isoenzymes in lung, colon and liver carcinomas. Br. J. Cancer 76, 600-605
61. Zarghami, N., Giai, M., Yu, H., Roagna, R., Ponzone, R., Katsaros, D., Sismondi, P., and Diamandis, E. P. (1996) Creatine kinase BB isoenzyme levels in tumour cytosols and survival of breast cancer patients. Br. J. Cancer 73, 386-390
62. Liippo, K. K., and Terho, T. (1991) Concomitant monitoring of serum neuron-specific enolase and creatine kinase BB in small cell lung cancer. Acta Oncol. 30, 321-324
63. Huddleston, H. G., Wong, K. K., Welch, W. R., Berkowitz, R. S., and Mok, S. C. (2005) Clinical applications of microarray technology: creatine kinase B is an up-regulated gene in epithelial ovarian cancer and shows promise as a serum marker. Gynecol. Oncol. 96, 77-83
64. Lin, L. M., and Chen, Y. K. (1991) Creatine kinase isoenzymes activity in serum and buccal pouch tissue of hamsters during DMBA-induced squamous cell carcinogenesis. J. Oral Pathol. Med. 20, 479-485
65. Balasubramani, M., Day, B. W., Schoen, R. E., and Getzenberg, R. H. (2006) Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. Cancer Res. 66, 763-769
66. Joseph, J., Cardesa, A., and Carreras, J. (1997) Creatine kinase activity and isoenzymes in lung, colon and liver carcinomas. Br. J. Cancer 76, 600-605
67. Mooney, S. M., Rajagopalan, K., Williams, B. H., Zeng, Y., Christudass, C. S., Li, Y., Yin, B., Kulkarni, P., and Getzenberg, R. H. (2011) Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses. J. Cell. Biochem. 112, 1066-1075