Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Kohno, Tatsuro ^a,d   Kimura, Masafumi ^b   Sasaki, Mika ^c   Obata, Hideaki ^b,d   Amaya, Fumimasa ^c,d   Saito, Shigeru ^b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d Pain Mechanism Research Group   (Japan)

Author keywords

Antidepressants; N methyl d aspartate (nmda) receptor; Spinal analgesia

Indexed keywords

AMPA RECEPTOR; CITALOPRAM; DESIPRAMINE; MILNACIPRAN; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ANTIDEPRESSANT AGENT; CYCLOPROPANE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DORSAL ROOT; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HYPERALGESIA; LATENT PERIOD; MALE; NEUROMODULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINAL CORD STIMULATION; SYNAPTIC TRANSMISSION; TREATMENT DURATION; ANIMAL; IMMUNOHISTOCHEMISTRY; METABOLISM; POSTERIOR HORN CELL; SPINAL ANESTHESIA;

ANESTHESIA, SPINAL; ANIMALS; ANTIDEPRESSIVE AGENTS; CITALOPRAM; CYCLOPROPANES; DESIPRAMINE; IMMUNOHISTOCHEMISTRY; MALE; PATCH-CLAMP TECHNIQUES; POSTERIOR HORN CELLS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84862300095     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-45     Document Type: Article

References (50)

1. Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, Kalso EA, Loeser JD, Miaskowski C, Nurmikko TJ, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007, 132:237-251. 10.1016/j.pain.2007.08.033, 17920770.
2. Sindrup SH, Otto M, Finnerup NB, Jensen TS. Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol 2005, 96:399-409. 10.1111/j.1742-7843.2005.pto_96696601.x, 15910402.
3. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms?. Trends Neurosci 2003, 26:696-705. 10.1016/j.tins.2003.09.017, 14624855.
4. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci 2003, 23:5031-5040.
5. Eisenach JC, Gebhart GF. Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. Anesthesiology 1995, 83:1046-1054. 10.1097/00000542-199511000-00018, 7486155.
6. Hwang AS, Wilcox GL. Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain 1987, 28:343-355. 10.1016/0304-3959(87)90068-6, 3494977.
7. Kumazawa T, Perl ER. Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization. J Comp Neurol 1978, 177:417-434. 10.1002/cne.901770305, 412881.
8. Yoshimura M, Nishi S. Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 1993, 53:519-526. 10.1016/0306-4522(93)90216-3, 8098516.
9. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976, 17:1031-1036. 10.1016/0031-9384(76)90029-9, 14677603.
10. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32:77-88. 10.1016/0304-3959(88)90026-7, 3340425.
11. Malmberg AB, Yaksh TL. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992, 257:1276-1279. 10.1126/science.1381521, 1381521.
12. Obata H, Kimura M, Nakajima K, Tobe M, Nishikawa K, Saito S. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. J Pharmacol Exp Ther 2010, 334:1059-1065. 10.1124/jpet.110.168336, 20558774.
13. Obata H, Saito S, Koizuka S, Nishikawa K, Goto F. The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain. Anesth Analg 2005, 100:1406-1410. table of contents, 10.1213/01.ANE.0000149546.97299.A2, 15845695.
14. Otsuka N, Kiuchi Y, Yokogawa F, Masuda Y, Oguchi K, Hosoyamada A. Antinociceptive efficacy of antidepressants: assessment of five antidepressants and four monoamine receptors in rats. J Anesth 2001, 15:154-158. 10.1007/s005400170018, 14566514.
15. Yokogawa F, Kiuchi Y, Ishikawa Y, Otsuka N, Masuda Y, Oguchi K, Hosoyamada A. An investigation of monoamine receptors involved in antinociceptive effects of antidepressants. Anesth Analg 2002, 95:163-168. table of contents, 10.1097/00000539-200207000-00029, 12088962.
16. Kohno T, Wakai A, Ataka T, Ikoma M, Yamakura T, Baba H. Actions of midazolam on excitatory transmission in dorsal horn neurons of adult rat spinal cord. Anesthesiology 2006, 104:338-343. 10.1097/00000542-200602000-00020, 16436854.
17. Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci 2008, 28:4533-4540. 10.1523/JNEUROSCI.5349-07.2008, 2653863, 18434532.
18. Amaya F, Samad TA, Barrett L, Broom DC, Woolf CJ. Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. Pain 2009, 142:59-67. 10.1016/j.pain.2008.11.013, 2755568, 19135800.
19. Meller ST, Dykstra C, Gebhart GF. Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide. Neuroscience 1996, 71:327-335. 10.1016/0306-4522(95)00442-4, 9053788.
20. Ito A, Kumamoto E, Takeda M, Shibata K, Sagai H, Yoshimura M. Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord. J Neurosci 2000, 20:6302-6308.
21. Kawasaki Y, Kumamoto E, Furue H, Yoshimura M. Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. Anesthesiology 2003, 98:682-689. 10.1097/00000542-200303000-00016, 12606912.
22. Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C, Befort K, Woolf CJ, Ji RR. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 2004, 24:8310-8321. 10.1523/JNEUROSCI.2396-04.2004, 15385614.
23. Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999, 2:1114-1119. 10.1038/16040, 10570489.
24. Kawamata T, Omote K, Kawamata M, Namiki A. Analgesic effect of intrathecal desipramine on carrageenan-induced thermal hyperalgesia in the rat. Br J Anaesth 1999, 83:449-452. 10.1093/bja/83.3.449, 10655917.
25. Pancrazio JJ, Kamatchi GL, Roscoe AK, Lynch C. Inhibition of neuronal Na + channels by antidepressant drugs. J Pharmacol Exp Ther 1998, 284:208-214.
26. Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. J Pain 2007, 8:315-324. 10.1016/j.jpain.2006.10.001, 17175203.
27. Lavoie PA, Beauchamp G, Elie R. Tricyclic antidepressants inhibit voltage-dependent calcium channels and Na(+)-Ca2+ exchange in rat brain cortex synaptosomes. Can J Physiol Pharmacol 1990, 68:1414-1418. 10.1139/y90-215, 2285885.
28. Shimizu M, Nishida A, Yamawaki S. Antidepressants inhibit spontaneous oscillations of intracellular Ca2+ concentration in rat cortical cultured neurons. Neurosci Lett 1992, 146:101-104. 10.1016/0304-3940(92)90182-7, 1475042.
29. Phillis JW, Wu PH. The effect of various centrally active drugs on adenosine uptake by the central nervous system. Comp Biochem Physiol C 1982, 72:179-187.
30. Isenberg KE, Cicero TJ. Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds. Eur J Pharmacol 1984, 103:57-63. 10.1016/0014-2999(84)90189-4, 6090179.
31. Hall H, Ogren SO. Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 1981, 70:393-407. 10.1016/0014-2999(81)90172-2, 6262100.
32. Reynolds IJ, Miller RJ. Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc. Br J Pharmacol 1988, 95:95-102. 10.1111/j.1476-5381.1988.tb16552.x, 1854115, 2905906.
33. Sills MA, Loo PS. Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate. Mol Pharmacol 1989, 36:160-165.
34. Sernagor E, Kuhn D, Vyklicky L, Mayer ML. Open channel block of NMDA receptor responses evoked by tricyclic antidepressants. Neuron 1989, 2:1221-1227. 10.1016/0896-6273(89)90306-1, 2483111.
35. Mochizuki D, Tsujita R, Yamada S, Kawasaki K, Otsuka Y, Hashimoto S, Hattori T, Kitamura Y, Miki N. Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats. Psychopharmacology (Berl) 2002, 162:323-332.
36. Shuto S, Takada H, Mochizuki D, Tsujita R, Hase Y, Ono S, Shibuya N, Matsuda A. (+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists. J Med Chem 1995, 38:2964-2968. 10.1021/jm00015a019, 7636857.
37. Moret C, Charveron M, Finberg JP, Couzinier JP, Briley M. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 1985, 24:1211-1219. 10.1016/0028-3908(85)90157-1, 3005901.
38. Watanabe Y, Saito H, Abe K. Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices. Neuropharmacology 1993, 32:479-486. 10.1016/0028-3908(93)90173-Z, 8321429.
39. Shin SW, Eisenach JC. Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran. Anesthesiology 2004, 100:671-675. 10.1097/00000542-200403000-00030, 15108984.
40. King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. J Pain 2006, 7:513-520. 10.1016/j.jpain.2006.02.001, 16814690.
41. Yanagidate F, Strichartz GR. Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors. Anesthesiology 2006, 104:805-814. 10.1097/00000542-200604000-00027, 16571978.
42. Kawasaki Y, Kohno T, Ji RR. Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats. J Pharmacol Exp Ther 2006, 316:601-607.
43. White G, Lovinger DM, Peoples RW, Weight FF. Inhibition of N-methyl-D-aspartate activated ion current by desmethylimipramine. Brain Res 1990, 537:337-339. 10.1016/0006-8993(90)90381-K, 1707733.
44. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994, 12:529-540. 10.1016/0896-6273(94)90210-0, 7512349.
45. Tolle TR, Berthele A, Zieglgansberger W, Seeburg PH, Wisden W. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci 1993, 13:5009-5028.
46. Davies SN, Lodge D. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res 1987, 424:402-406. 10.1016/0006-8993(87)91487-9, 2823998.
47. Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 1987, 26:1235-1238. 10.1016/0028-3908(87)90275-9, 2821443.
48. Domino EF. Taming the ketamine tiger. 1965. Anesthesiology 2010, 113:678-684.
49. Gendreau RM, Thorn MD, Gendreau JF, Kranzler JD, Ribeiro S, Gracely RH, Williams DA, Mease PJ, McLean SA, Clauw DJ. Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol 2005, 32:1975-1985.
50. Mease PJ, Clauw DJ, Gendreau RM, Rao SG, Kranzler J, Chen W, Palmer RH. The efficacy and safety of milnacipran for treatment of fibromyalgia. a randomized, double-blind, placebo-controlled trial. J Rheumatol 2009, 36:398-409. 10.3899/jrheum.080734, 19132781.