Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules

Biochemical Pharmacology

Volumn 78, Issue 9, 2009, Pages 1167-1177

  Dalyot Herman, Nava ^a   Delgado Lopez, Fernando ^a   Gewirtz, David A ^b   Gupton, John T ^c   Schwartz, Edward L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF RICHMOND   (United States)

Author keywords

Angiogenesis inhibitors; JG 03 14; Microtubule binding drugs; Vascular disrupting drugs; VE cadherin

Indexed keywords

3,5 DIBROMO 4(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; ACTIN; BETA CATENIN; COLCHICINE; COMBRETASTATIN A4; FOCAL ADHESION KINASE; JG 03 14; PYRROLE DERIVATIVE; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL JUNCTION; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; FOCAL ADHESION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROTUBULE; MORPHOGENESIS; PRIORITY JOURNAL;

BINDING SITES; CELLS, CULTURED; COLCHICINE; ENDOTHELIUM, VASCULAR; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MICROTUBULES; PHOSPHORYLATION; PYRROLES; WOUND HEALING;

EID: 70249135233     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.06.093     Document Type: Article

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