Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7- (naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio hartree-fock calculations

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5403-5412

  Huynh, Tri H V ^a   Shim, Irene ^b   Bohr, Henrik ^b   Abrahamsen, Bjarke ^a   Nielsen, Birgitte ^a   Jensen, Anders A ^a   Bunch, Lennart ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (4 METHOXYPHENYL) 7 (NAPHTHALEN 1YL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 PHENYL 7 1 PHENYLETHYL) 5,6,7,8 TETRAHYDRO 4H PYRANO[2,3 C]PYRIDINE 3 CARBONITRILE; AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; NEUROTRANSMITTER; SODIUM GLUCOSE COTRANSPORTER 1; UCPH 101; UCPH 102; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; CIRCULAR DICHROISM; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; INFRARED RADIATION; ISOMER; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYNAPSE;

ASPARTIC ACID; BENZOPYRANS; CIRCULAR DICHROISM; EXCITATORY AMINO ACID TRANSPORTER 1; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 84862281739     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300345z     Document Type: Article

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