Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7- (naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4 H -chromene-3-carbonitrile (UCPH-101)

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 7180-7191

  Erichsen, Mette N ^a   Huynh, Tri H V ^a   Abrahamsen, Bjarke ^a   Bastlund, Jesper F ^b   Bundgaard, Christoffer ^b   Monrad, Olja ^a   Bekker Jensen, Anders ^a   Nielsen, Christina W ^a   Frydenvang, Karla ^a   Jensen, Anders A ^a   Bunch, Lennart ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 (DIETHOXYMETHYL) 3 PHENYLACRYLONITRILE; 2 AMINO 4 (4 METHOXYPHENYL) 7 (NAPHTHALEN 1 YL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 METHYL 7 (NAPHTHALEN 1 YL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4,4 DIMETHYL 5 OXO 7 PHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4,7 DIPHENYL 7,8 DIHYDRO 4H CHROMEN 5(6H)ONE; 2 AMINO 5 OXO 4,7 DIPHENYL 4,5,7,8 TETRAHYDROPYRANO[4,3 B] PYRAN 3 CARBONITRILE; 2 AMINO 5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H PYRANO [3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 7 BENZYL 4 (4 METHOXYPHENYL) 5 OXO-5,6,7,8 TETRA HYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO-5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBOXAMIDE; 2 CYANO 3 PHENYLACRYLAMIDE; 2 FORMYL 3 PHENYLACRYLONITRILE; 4 (NAPHTHALENE 2 YL)BUT 3 EN 2 ONE; 5 (NAPHTHALEN 2 YL)CYCLOHEXANE 1,3 DIONE; 5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 6 PHENYLDIHYDRO 2H PYRAN 2,4(3H)DIONE; 6 PHENYLPIPERIDINE 2,4 DIONE; CENTRAL NERVOUS SYSTEM AGENTS; ETHYL N 3 CYANO 5 OXO 4,7 DIPHENYL-5,6,7,8 TETRAHYDRO 4H CHROMEN 2 YLFORMIMIDATE; EXCITATORY AMINO ACID TRANSPORTER INHIBITOR; METHYL 2 AMINO 5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBOXYLATE; METHYL 2 CYANO 3 PHENYLACRYLATE; METHYL 5 (TERT BUTOXYCARBONYLAMINO) 3 OXO 5 PHENYLPENTANOATE; METHYL 5 HYDROXY 3 OXO 5 PHENYLPENTANOATE; N(3 CYANO 5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMEN 2 YL)ACETAMIDE; TERT BUTYL 2 AMINO-5 OXO 4,7 DIPHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBOXYLATE; TERT BUTYL 2 CYANO 3 PHENYLACRYLATE; TERT BUTYL BENZYLIDENECARBAMATE; TERT BUTYL PHENYL(PHENYLSULFONYL)METHYLCARBAMATE; UCPH 101; UNCLASSIFIED DRUG; UNINDEXED DRUG; 2-AMINO-4-(4-METHOXYPHENYL)-7-(NAPHTHALEN-1-YL)-5-OXO-5,6,7,8-TETRAHYDRO-4H-CHROMENE-3-CARBONITRILE; BENZOPYRAN DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER 1; KETONE; LACTAM; LACTONE; NITRILE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CHEMICAL STRUCTURE; CHEMISTRY; MALE; METABOLISM; SPRAGUE DAWLEY RAT; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOPYRANS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CRYSTALLOGRAPHY, X-RAY; EXCITATORY AMINO ACID TRANSPORTER 1; KETONES; LACTAMS; LACTONES; MALE; MODELS, MOLECULAR; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957901181     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1009154     Document Type: Article

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