Getting the MAX out of computational models: The prediction of unbound-brain and unbound-plasma maximum concentrations

ACS Medicinal Chemistry Letters

Volumn 3, Issue 6, 2012, Pages 515-519

  Mente, Scot ^a   Doran, Angela ^a   Wager, Travis T ^a  

^a PFIZER INC   (United States)

Author keywords

ADME; blood brain barrier; brain availability; C max; fraction unbound; volume of distribution

Indexed keywords

AREA UNDER THE CURVE; ARTICLE; IN VITRO STUDY; MATHEMATICAL COMPUTING; MAXIMUM PLASMA CONCENTRATION; MICROSOME; PRIORITY JOURNAL;

EID: 84862279837     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300029a     Document Type: Article

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