Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB 1 receptor ligand

Pharmacological Research

Volumn 66, Issue 2, 2012, Pages 163-169

  Ligresti, Alessia ^a   Villano, Rosaria ^a   Allarà, Marco ^a   Ujváry, István ^b   Di Marzo, Vincenzo ^a  

^a CNR   (Italy)

^b IKem BT   (Hungary)

Author keywords

Cannabinoid; Cannabinoid receptors; CB 1; CB 2; Endocannabinoid; FAAH; Kava; MAGL; Natural products

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DEMETHOXYYANGONIN; DIHYDROKAWAIN; DIHYDROMETHYSTICIN; ENDOCANNABINOID; FATTY ACID AMIDASE; KAVALACTONE; KAWAIN; LACTONE DERIVATIVE; METHYSTICIN; RADIOLIGAND; UNCLASSIFIED DRUG; YANGONIN;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME INHIBITION; HYDROLYSIS; IC 50; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; BINDING, COMPETITIVE; ENDOCANNABINOIDS; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; LIGANDS; MONOACYLGLYCEROL LIPASES; PIPER; PYRANS; PYRONES; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862274187     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.04.003     Document Type: Article

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