HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Mishra, Ritu ^a   Chhatbar, Chintan ^a   Singh, Sunit K ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

HIV and miRNA; HIV Neuroinflammation; HIV Tat and bystander effects; HIV Tat and gene regulation; HIV Tat protein; Microrna; Tat and mirna

Indexed keywords

INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; MESSENGER RNA; MESSENGER RNA 32; PROTEIN C; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG;

ARTICLE; BYSTANDER EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ASSAY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LUCIFERASE ASSAY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN RNA BINDING; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; WESTERN BLOTTING;

EID: 84862251642     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-131     Document Type: Article

References (47)

1. Thompson KA, Cherry CL, Bell JE, McLean CA. Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals. Am J Pathol 2011, 179:1623-1629. 10.1016/j.ajpath.2011.06.039, 21871429.
2. Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010, 75:2087-2096. 10.1212/WNL.0b013e318200d727, 2995535, 21135382.
3. Sharma D, Bhattacharya J. Cellular & molecular basis of HIV-associated neuropathogenesis. Indian J Med Res 2009, 129:637-651.
4. Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ 2005, 12(Suppl 1):878-892.
5. Sanders VJ, Mehta AP, White MG, Achim CL. A murine model of HIV encephalitis: xenotransplantation of HIV-infected human neuroglia into SCID mouse brain. Neuropathol Appl Neurobiol 1998, 24:461-467. 10.1046/j.1365-2990.1998.00145.x, 9888156.
6. Del Valle L, Croul S, Morgello S, Amini S, Rappaport J, Khalili K. Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with progressive multifocal leukoencephalopathy. J Neurovirol 2000, 6:221-228. 10.3109/13550280009015824, 10878711.
7. Ju SM, Song HY, Lee JA, Lee SJ, Choi SY, Park J. Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-kappaB dependent pathway in human astrocytes. Exp Mol Med 2009, 41:86-93. 10.3858/emm.2009.41.2.011, 2679334, 19287189.
8. Deshmane SL, Mukerjee R, Fan S, Sawaya BE. High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons. PLoS One 2011, 6:e16148. 10.1371/journal.pone.0016148, 3017553, 21249135.
9. Li W, Li G, Steiner J, Nath A. Role of Tat protein in HIV neuropathogenesis. Neurotox Res 2009, 16:205-220. 10.1007/s12640-009-9047-8, 19526283.
10. Lewis SD, Butchi NB, Khaleduzzaman M, Morgan TW, Du M, Pourciau S, Baker DG, Akira S, Peterson KE. Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation. J Neurovirol 2008, 14:492-502. 10.1080/13550280802345723, 19016073.
11. Kraft AD, Harry GJ. Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Res Public Health 2011, 8:2980-3018. 10.3390/ijerph8072980, 3155341, 21845170.
12. Antony JM. Grooming and growing with microglia. Sci Signal 2010, 3:jc8. 10.1126/scisignal.3147jc8, 21062990.
13. Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B. Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line. J Mol Biol 2007, 366:67-81. 10.1016/j.jmb.2006.11.011, 17157319.
14. Hudson L, Liu J, Nath A, Jones M, Raghavan R, Narayan O, Male D, Everall I. Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues. J Neurovirol 2000, 6:145-155. 10.3109/13550280009013158, 10822328.
15. Singh SK. miRNAs: from neurogeneration to neurodegeneration. Pharmacogenomics 2007, 8:971-978. 10.2217/14622416.8.8.971, 17716230.
16. Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X, Zhang JP, Guan XY, Zhuang SM. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 2011, 54:1729-1740. 10.1002/hep.24577, 21793034.
17. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S, Kim VN. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425:415-419. 10.1038/nature01957, 14508493.
18. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010, 10:111-122. 10.1038/nri2708, 20098459.
19. Eacker SM, Dawson TM, Dawson VL. Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 2009, 10:837-841.
20. Shahabi HN, Westberg L, Melke J, Hakansson A, Belin AC, Sydow O, Olson L, Holmberg B, Nissbrandt H. Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population. J Neural Transm 2009, 116:567-573. 10.1007/s00702-009-0221-1, 19381774.
21. Chang JR, Mukerjee R, Bagashev A, Del Valle L, Chabrashvili T, Hawkins BJ, He JJ, Sawaya BE. HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. J Biol Chem 2011, 286:41125-41134. 10.1074/jbc.M111.268466, 21956116.
22. Ely KR, Kodandapani R, Wu S. Protein-protein interactions in TRAF3. Adv Exp Med Biol 2007, 597:114-121. 10.1007/978-0-387-70630-6_9, 17633021.
23. Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, Yamaoka S. TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem 2003, 278:36005-36012. 10.1074/jbc.M304266200, 12840022.
24. Hacker H, Tseng PH, Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol 2011, 11:457-468. 10.1038/nri2998, 21660053.
25. Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B, Perry A, Cheng G. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2006, 439:208-211. 10.1038/nature04374, 16306936.
26. Perez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, et al. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity 2010, 33:400-411. 10.1016/j.immuni.2010.08.014, 2946444, 20832341.
27. Bista P, Zeng W, Ryan S, Bailly V, Browning JL, Lukashev ME. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem 2010, 285:12971-12978. 10.1074/jbc.M109.076091, 2857099, 20185819.
28. Zarnegar B, Yamazaki S, He JQ, Cheng G. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci U S A 2008, 105:3503-3508. 10.1073/pnas.0707959105, 2265190, 18292232.
29. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem 2010, 285:9470-9476. 10.1074/jbc.M109.071043, 2843197, 20097753.
30. Romani B, Engelbrecht S, Glashoff RH. Functions of Tat: the versatile protein of human immunodeficiency virus type 1. J Gen Virol 2010, 91:1-12. 10.1099/vir.0.016303-0, 19812265.
31. Boss IW, Renne R. Viral miRNAs and immune evasion. Biochim Biophys Acta 2011, 1809:708-714. 10.1016/j.bbagrm.2011.06.012, 21757042.
32. Hornstein E, Shomron N. Canalization of development by microRNAs. Nat Genet 2006, 38(Suppl):S20-S24.
33. Cao X, Pfaff SL, Gage FH. A functional study of miR-124 in the developing neural tube. Genes Dev 2007, 21:531-536. 10.1101/gad.1519207, 1820895, 17344415.
34. Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K, Gualco E, Peruzzi F. Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. J Cell Physiol 2008, 216:764-770. 10.1002/jcp.21452, 2662126, 18381601.
35. Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988, 55:1189-1193. 10.1016/0092-8674(88)90263-2, 2849510.
36. Cardarelli F, Serresi M, Albanese A, Bizzarri R, Beltram F. Quantitative analysis of Tat peptide binding to import carriers reveals unconventional nuclear transport properties. J Biol Chem 2011, 286:12292-12299. 10.1074/jbc.M110.203083, 3069432, 21321119.
37. Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, Kim TK, Greenberg ME, Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J 2009, 28:697-710. 10.1038/emboj.2009.10, 2647767, 19197241.
38. Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog 2009, 5:e1000650. 10.1371/journal.ppat.1000650, 2766052, 19893624.
39. Wang L, Toomey NL, Diaz LA, Walker G, Ramos JC, Barber GN, Ning S. Oncogenic IRFs Provide a Survival Advantage for Epstein-Barr Virus- or Human T-Cell Leukemia Virus Type 1-Transformed Cells through Induction of BIC Expression. J Virol 2011, 85:8328-8337. 10.1128/JVI.00570-11, 3147954, 21680528.
40. Xiao G, Fong A, Sun SC. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 2004, 279:30099-30105. 10.1074/jbc.M401428200, 15140882.
41. Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001, 7:401-409. 10.1016/S1097-2765(01)00187-3, 11239468.
42. Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev 2011, 244:55-74. 10.1111/j.1600-065X.2011.01055.x, 22017431.
43. Tang ED, Wang CY. TRAF5 is a downstream target of MAVS in antiviral innate immune signaling. PLoS One 2010, 5:e9172. 10.1371/journal.pone.0009172, 2820086, 20161788.
44. Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 2010, 11:70-75. 10.1038/ni.1819, 2872790, 19898473.
45. He L, Grammer AC, Wu X, Lipsky PE. TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. J Biol Chem 2004, 279:55855-55865. 10.1074/jbc.M407284200, 15383523.
46. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008, 321:663-668. 10.1126/science.1157340, 2669719, 18635759.
47. Sun F, Zhang YB, Liu TK, Shi J, Wang B, Gui JF. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol 2011, 187:2531-2539. 10.4049/jimmunol.1100642, 21795596.