A murine model of HIV encephalitis: Xenotransplantation of HIV-infected human neuroglia into SCID mouse brain

Neuropathology and Applied Neurobiology

Volumn 24, Issue 6, 1998, Pages 461-467

  Sanders, V J ^a   Mehta, A P ^a   White, M G ^a   Achim, C L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

HIV encephalitis; In vivo model; Xenotransplantation

Indexed keywords

CELL MARKER; CYCLINE; SYNAPSIN;

ANIMAL MODEL; ARTICLE; BRAIN TISSUE; CELL PROLIFERATION; CORPUS STRIATUM; ELECTRON MICROSCOPY; GLIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MOUSE; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SCID MOUSE; SYNAPSE; VIRUS DETECTION; VIRUS ENCEPHALITIS; XENOTRANSPLANTATION;

AIDS DEMENTIA COMPLEX; ANIMALS; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FETAL TISSUE TRANSPLANTATION; HUMANS; MACROPHAGES; MALE; MICE; MICE, SCID; MICROSCOPY, ELECTRON; NEUROGLIA; SEVERE COMBINED IMMUNODEFICIENCY; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032407502     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.1998.00145.x     Document Type: Article

References (17)

1. Achim CL, Miners UK, Burrola PG, Martin PC, Wiley CA. In vivo model of HIV infection of the human brain. Dev Neurosci 1993; 15:425-32
2. Boche D, Hurtrel M, Gray F et al. Virus load and neuropathology in the FIV model. J Neurovirol 1996; 2: 377-87
3. Epstein LG. The human neural xenograft model of HIV-1 infection and neurotoxicity. J. Neurochem 1994; 62: 90
4. Epstein LG, Cvetkovich TA, Lazar E et al. Successful xenografts of second trimester human fetal brain and retinal tissue in the anterior chamber of the eye of adult immunosuppressed rats. J Neural Transplant Plasticity 1992; 3: 151-8
5. Klotman PE, Notkins AL. Transgenic models of human immunodefiency virus type-1. In Transgenic Models of Human Viral and Immunological Disease, ed. Chisari FV and Oldstone MBA. Berlin: Springer. 1996: 198-222
6. Lackner AA, Smith MO, Munn RJ et al. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991; 139: 609-21
7. Masliah E. In vivo modeling of HIV-1 mediated neurodegeneration. Am J Pathol 1996; 149: 745-50
8. McArthur JC. Neurological and neuropathological manifestations of HIV infection. In Neuropsychology of HIV Infection. ed. Grant I and Martin A. New York: Oxford University Press, 1994: 56-107
9. Narayan O, Stephens EB, Joag SV, Chebloune Y. Animal models of human immunodeficiency virus neurological disease, in AIDS and the nervous system, ed. Philadelphia: Lippincott-Raven Publishers. 1997: 123-40
10. Navia BA, Cho E-S, Petito CK, Price RW. The AIDS dementia complex: II Neuropathology. Ann Neurol 1986; 19: 525-35
11. Persidsky Y, Buttini M, Limoges J, Bock P, Gendelman HE. An analysis of HIV-1 associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. J Neurovirol 1997; 3: 401-16
12. Persidsky Y, Gendelman HE. Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia. J Leuko Biol 1997; 62: 100-6
13. Persidsky Y, Limoges J, McComb R et al. Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol 1996; 149: 1027-53
14. Podell M, Oglesbee M, Mathes L, Krakowka S, Olmstead R, Lafrado L. AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection. J AIDS 1993; 6: 758-71
15. Poli G, Abramo F, Diiorio C et al. Neuropathology in cats experimentally infected with feline immunodeficiency virus-a morphological, immunocytochemical and morphometric study. J Neurovirol 1997; 3: 361-8
16. Schrier RD, McCutchan JA, Wiley CA. Mechanisms of immune activation of human immunodeficiency virus in monocytes/macrophages. J Virol 1993; 67: 5713-20
17. Tyor WR, Power C, Gendelman HE, Markham RB. A model of human immunodeficiency virus encephalitis in seid mice. Proc Natl Acad Sci U S A 1993; 90: 8658-62