Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy

Journal of Nephrology

Volumn 25, Issue 2, 2012, Pages 233-239

  Ohnuki, Keiko ^a   Umezono, Tomoya ^a   Abe, Makiko ^a   Kobayashi, Takako ^a   Kato, Mayuko ^a   Miyauchi, Masaaki ^a   Yamamoto, Naoyuki ^a   Kimura, Moritsugu ^a   Toyoda, Masao ^a   Suzuki, Daisuke ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

Epithelial mesenchymal transition; Immunohistochemistry for Snai1; Tubulointerstitial fibrosis; Vimentin

Indexed keywords

CREATININE; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR SNAI1; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; DIABETIC NEPHROPATHY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MALE; MINIMAL CHANGE GLOMERULONEPHRITIS; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEINURIA; TUBULOINTERSTITIAL FIBROSIS;

ADULT; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY DISEASES; MALE; MIDDLE AGED; TRANSCRIPTION FACTORS; VIMENTIN;

EID: 84862238857     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2011.8449     Document Type: Article

References (25)

1. Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis. 1992;20:1-17.
2. D'Amico G, Ferrario F, Rastaldi MP. Tubulointerstitial damage in glomerular diseases: its role in the progression of renal damage. Am J Kidney Dis. 1995;26:124-132.
3. Risdon RA, Sloper JC, DeWardener HE. Relationship between renal function and histological changes found in renalbiopsy specimens from patients with persistent glomerular nephritis. Lancet. 1968;2:363-366.
4. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol. 2004;15:1-12.
5. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003;112:1776-1784.
6. Lange-Sperandio B, Trautmann A, Eickelberg O, et al. Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol. 2007;171:861-871.
7. Boutet A, De Frutos CA, Maxwell PH, et al. Snail activation disrupts tissue homeostasis and induces fibrosis in adult kidney. EMBO J. 2006;25:5603-5613.
8. Matsui I, Ito T, Kurihara H, et al. Snail, a transcriptional regulator, represses nephrin expression in glomerular epithelial cells of nephritic rats. Lab Invest. 2007;87:273-283.
9. Zhou BP, Deng J, Xia W, et al. Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol. 2004;6:931-940.
10. Batlle E, Sancho E, Franci C, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells. Nat Cell Biol. 2000;2:84-89.
11. 1 controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature. 2004;429:298-302.
12. Li Y, Tan X, Dai C, et al. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol. 2009;20:1907-1918.
13. Ruger BM, Hasan Q, Greenhill NS, et al. Mast cell and type VIII collagen in human diabetic nephropathy. Diabetologia. 1996;39:1215-1222.
14. Hiromura K, Kurosawa M, Yano S, et al. Tubulointerstitial mast cell infiltration in glomerulonephritis. Am J Kidney Dis. 1998;32:593-599.
15. Ehara T, Shigematsu H. Contribution of mast cell to the tubulointerstitial lesions in IgA nephritis. Kidney Int. 1998;54:1675-1683.
16. Kurusu A, Suzuki Y, Horikoshi S, et al. Relationship between mast cell in the tubulointerstitium and prognosis of patients with IgA nephropathy. Nephron. 2001;89:391-397.
17. Wang SN, Lapage J, Hirschberg R. Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy. Kidney Int. 2000;57:1002-1014.
18. Chevalier RL. Specific molecular targeting of renal injury in obstructive nephropathy. Kidney Int. 2006;70:1200-1201.
19. Böttinger EP. TGF-beta in renal injury and disease. Semin Nephrol. 2007;27:309-320.
20. Pozdzik AA, Salmon IJ, Husson CP, et al. Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy. Nephrol Dial Transplant. 2008;23:2480-2491.
21. Tamura M, Aizawa R, Hori M, et al. Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model. Histochem Cell Biol. 2009;131:483-490.
22. Ito Y, Aten J, Bende RJ, et al. Expression of connective tissue growth factor in human renal fibrosis. Kidney Int. 1998;53:853-861.
23. Rastaldi MP, Ferrario F, Giardino L, et al. Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int. 2002;62:137-146.
24. Manotham K, Tanaka T, Matsumoto M, et al. Transdifferentiation of cultured tubular cells induced by hypoxia. Kidney Int. 2004;65:871-880.
25. Bazzi C, Petrini C, Rizza V, et al. A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephrotic syndrome. Kidney Int. 2000;58:1732-1741.