Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model

Histochemistry and Cell Biology

Volumn 131, Issue 4, 2009, Pages 483-490

  Tamura, Mizuho ^a,b   Aizawa, Reiko ^b   Hori, Masatoshi ^a   Ozaki, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TEIJIN PHARMA LIMITED   (Japan)

Author keywords

Adenine; Fibroblast; Interstitial fibrosis; Macrophage; Tubulointerstitial nephritis

Indexed keywords

2,8 DIHYDROXYADENINE; ADENINE; ALPHA SMOOTH MUSCLE ACTIN; CHEMOKINE RECEPTOR CCR2; COLLAGEN TYPE 1; CREATININE; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FIBROSING ALVEOLITIS; GENE EXPRESSION; INTERSTITIAL NEPHRITIS; KIDNEY DYSFUNCTION; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UROLITHIASIS; WEIGHT REDUCTION;

ACTINS; ADENINE; ANIMALS; CHEMOKINES; CHEMOTAXIS; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; FIBROSIS; KIDNEY TUBULES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NEPHRITIS, INTERSTITIAL;

MUS;

EID: 64649098703     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-009-0557-5     Document Type: Article

References (27)

1. M Abbate C Zoja G Remuzzi 2006 How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17 2974 2984
2. HJ Anders V Vielhauer D Schlondorff 2003 Chemokines and chemokine receptors are involved in the resolution or progression of renal disease Kidney Int 63 401 415
3. A de Vries O Sperling 1977 Implications of disorders of purine metabolism for the kidney and the urinary tract Ciba Found Symp 48 179 206
4. L Ding M Zhao W Zou Y Liu H Wang 2004 Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study Lupus 13 113 118
5. SJ Engle MG Stockelman J Chen G Boivin MN Yum PM Davies MY Ying A Sahota HA Simmonds PJ Stambrook JA Tischfield 1996 Adenine phosphoribosyltransferase- deficient mice develop 2, 8-dihydroxyadenine nephrolithiasis Proc Natl Acad Sci USA 93 5307 5312
6. M Iwano D Plieth TM Danoff C Xue H Okada EG Neilson 2002 Evidence that fibroblasts derive from epithelium during tissue fibrosis J Clin Invest 110 341 350
7. R Kalluri EG Neilson 2003 Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 112 1776 1784
8. K Kitagawa T Wada K Furuichi H Hashimoto Y Ishiwata M Asano M Takeya WA Kuziel K Matsushima N Mukaida H Yokoyama 2004 Blockade of CCR2 ameliorates progressive fibrosis in kidney Am J Pathol 165 237 246
9. A Miyajima J Chen C Lawrence S Ledbetter RA Soslow J Stern S Jha J Pigato ML Lemer DP Poppas ED Vaughan D Felsen 2000 Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction Kidney Int 58 2301 2313
10. FS Monteclaro IF Charo 1996 The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation J Biol Chem 271 19084 19092
11. Y Motomura WI Khan RT El-Sharkawy M Verma-Gandhu EF Verdu J Gauldie SM Collins 2006 Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1 Gut 55 662 670
12. JM Myllymaki TT Honkanen JT Syrjanen HJ Helin IS Rantala AI Pasternack JT Mustonen 2007 Severity of tubulointerstitial inflammation and prognosis in immunoglobulin A nephropathy Kidney Int 71 343 348
13. KA Nath 1998 The tubulointerstitium in progressive renal disease Kidney Int 54 992 994
14. DJ Nikolic-Paterson RC Atkins 2001 The role of macrophages in glomerulonephritis Nephrol Dial Transplant 16 Suppl 5 3 7
15. H Okada R Kalluri 2005 Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis Curr Mol Med 5 467 474
16. B Rodriguez-Iturbe H Pons J Herrera-Acosta RJ Johnson 2001 Role of immunocompetent cells in nonimmune renal diseases Kidney Int 59 1626 1640
17. K Sean Eardley P Cockwell 2005 Macrophages and progressive tubulointerstitial disease Kidney Int 68 437 455
18. S Segerer PJ Nelson D Schlondorff 2000 Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies J Am Soc Nephrol 11 152 176
19. MG Stockelman JN Lorenz FN Smith GP Boivin A Sahota JA Tischfield PJ Stambrook 1998 Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency Am J Physiol 275 F154 F163
20. V Vielhauer HJ Anders M Mack J Cihak F Strutz M Stangassinger B Luckow HJ Grone D Schlondorff 2001 Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes J Am Soc Nephrol 12 1173 1187
21. T Wada H Yokoyama K Furuichi KI Kobayashi K Harada M Naruto SB Su M Akiyama N Mukaida K Matsushima 1996 Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1) FASEB J 10 1418 1425
22. T Wada K Furuichi N Sakai Y Iwata K Yoshimoto M Shimizu SI Takeda K Takasawa M Yoshimura H Kida KI Kobayashi N Mukaida T Naito K Matsushima H Yokoyama 2000 Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy Kidney Int 58 1492 1499
23. T Wada K Furuichi N Sakai Y Iwata K Kitagawa Y Ishida T Kondo H Hashimoto Y Ishiwata N Mukaida N Tomosugi K Matsushima K Egashira H Yokoyama 2004 Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis J Am Soc Nephrol 15 940 948
24. S Yamagami H Tanaka N Endo 1997 Monocyte chemoattractant protein-2 can exert its effects through the MCP-1 receptor (CC CKR2B) FEBS Lett 400 329 332
25. H Yokoyama T Wada K Furuichi C Segawa M Shimizu K Kobayashi S Su N Mukaida K Matsushima 1998 Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy J Leukoc Biol 63 493 499
26. T Yokozawa H Oura F Koizumi 1985 2, 8-Dihydroxyadenine urolithiasis induced by dietary adenine in rats Nippon Jinzo Gakkai Shi 27 371 378
27. T Yokozawa PD Zheng H Oura F Koizumi 1986 Animal model of adenine-induced chronic renal failure in rats Nephron 44 230 234