In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway

BMC Microbiology

Volumn 12, Issue , 2012, Pages

  Schwentke, Andreas ^a   Krepstakies, Marcel ^b   Mueller, Ann Kristin ^c   Hammerschmidt Kamper, Christiane ^c   Motaal, Basma A ^b   Bernhard, Tina ^a   Hauber, Joachim ^b   Kaiser, Annette ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYHYPUSINE SYNTHASE; INITIATION FACTOR 5A; MESSENGER RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE CONSTRUCT; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCHIZONT; T LYMPHOCYTE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; MALARIA; MICE; MICE, TRANSGENIC; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PARASITEMIA; PEPTIDE INITIATION FACTORS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA-BINDING PROTEINS; VIRULENCE;

ANIMALIA; EUKARYOTA; MURINAE; MUS; PLASMODIUM (APICOMPLEXA); PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 84862164680     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-12-107     Document Type: Article

References (35)

1. Dicing and Splicing. The core machinery of the RNA interference pathway. Hammond SM, FEBS Lett 2005 579 5822 5829 10.1016/j.febslet.2005.08.079 16214139 (Pubitemid 41484128)
2. Role for a bidentate ribonuclease in the initiation step of RNA interference. Bernstein E, Caudy AA, Hammond SM, Hannon GJ, Nature 2001 409 363 366 10.1038/35053110 11201747 (Pubitemid 32151243)
3. ATP requirements and small interfering RNA structure in the RNA interference pathway. Nykanem A, Haley B, Zamore PD, Cell 2001 107 309 321 10.1016/S0092-8674(01)00547-5 11701122 (Pubitemid 33049975)
4. Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Baum J, Papenfuss AT, Mair GR, Janse CJ, Vlachou D, Waters AP, Cowman AF, Crabb CJ, Koning-Ward TF, Nucl. Acid Res. 2010 37 11 3788 3798
5. PfMyb1, a Plasmodium falciparum transcription factor, is required for intra-erythrocytic growth and controls key genes for cell cycle regulation. Gissot M, Brique S, Refour P, Boschet C, Vaquero C, J Mol Biol 2005 34 29 42 (Pubitemid 40128304)
6. Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference. Kumar R, Adams B, Oldenburg A, Musiyenko A, Barik S, Malar J 2002 145 1245 1254
7. Plasmodium falciparum signal peptidase is regulated by phosphorylation and required for intra-erythrocytic growth. Tuteja R, Pradhan A, Sharma S, Mol Biochem Parasitol 2008 157 137 147 10.1016/j.molbiopara.2007.10.007 18054093
8. RNA interference (RNAi) inhibits growth of P. falciparum. McRobert L, McConkey GA, Mol. Chem. Parasitol. 2002 119 273 278 10.1016/S0166-6851(01)00429- 7 (Pubitemid 34114066)
9. A role of falcipain-2, principle cysteine proteases of Plasmodium falciparum in merozoite egression. Dasaradhi PV, Mohammed A, Kumar A, Hossain MJ, Bhatnagar RK, Chauhan VS, Malhotra P, Biochem Biophys Res Commun 2005 336 1062 1068 10.1016/j.bbrc.2005.08.213 16165088 (Pubitemid 41383430)
10. Gene disruption confirms a critical role for the cysteine protease falcipain-2 in haemoglobin hydrolysis by Plasmodium falciparum. Sijwali PS, Rosenthal PJ, Proc. Natl. Acad. Sci. USA 2004 101 4384 4389 10.1073/pnas. 0307720101 15070727 (Pubitemid 38437421)
11. Targeting enzymes involved in spermidine metabolism of parasitic protozoa-a possible new strategy for anti-parasitic treatment. Kaiser A, Gottwald A, Maier W, Seitz HM, Parasitol Res 2003 91 6 508 516 10.1007/s00436-003-0970-y 14530966 (Pubitemid 38021658)
12. Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax. Njuguna JT, Nassar M, Hoerauf A, Kaiser AE, BMC Microbiol 2006 6 91 96 16 10.1186/1471-2180-6-91 17042947 (Pubitemid 44784577)
13. The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG, J Clin Invest 2011 20 6 2156 2170
14. Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. Hauber I, Bevec D, Heukeshoven J, Krätzer F, Horn F, Choidas A, Harrer T, Hauber J, J Clin Invest 2005 115 1 76 85 15630446 (Pubitemid 40385507)
15. Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. Bevec D, Kappel B, Jaksche H, Csonga R, Hauber J, Klier H, Steinkasserer A, FEBS Lett 1996 378 2 195 198 10.1016/0014-5793(95)01456-X 8549832 (Pubitemid 26018567)
16. Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. Hofmann W, Reichart B, Ewald A, Müller E, Schmitt I, Stauber RH, Lottspeich F, Jockusch BM, Scheer U, Hauber J, Dabauvalle MC, J Cell Biol. 2001 152 5 895 910 10.1083/jcb.152.5.895 11238447 (Pubitemid 34286067)
17. Hypusine: a new target for therapeutic intervention in diabetic inflammation. Maier B, Tersey SA, Mirmira RG, Discov. Med. 2010 10 50 18 23 20670594
18. Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice. Zanni GM, Cabrales P, Barkho W, Frangos J, Carvalho L, J Neuroinflamm. 2011 66 Zanni GM, Cabrales P, Barkho W, Frangos J, Carvalho L 1 9 8
19. Inhaled nitric oxide for the adjunctive therapy of severe malaria. Hawkes M, Opoka R, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC, Trials 2011 12 176 10.1186/1745-6215-12-176 21752262
20. Improving cognitive outcome in cerebral malaria: Insights from Clinical and Experimental Research. de SA Miranda, Brant F, Machado FS, Rachid MA, Teixera AL, Cent Nerv Syst Agents Med Chem 2011 11 4 285 295 11 22300229
21. Immunological processes in malaria pathogenesis. Schofield L, Grau GE, Nat Rev Immunol 2005 5 9 722 735 10.1038/nri1686 16138104 (Pubitemid 43086173)
22. The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase. Specht S, Sarite SR, Hauber I, Hauber J, Görbig UF, Meier C, Bevec D, Hoerauf A, Kaiser A, Parasitol Res 2008 102 6 1177 1184 10.1007/s00436-008-0891-x 18256853
23. CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. Cohen PS, Nakshatri H, Dennis J, Caragine T, Bianchi M, Cerami A, Tracey KJ, Proc Natl Acad Sci U S A 1996 93 9 3967 3971 10.1073/pnas.93.9.3967 8632999 (Pubitemid 26146719)
24. High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent parasite Plasmodium berghei. Janse CJ, Ramesar J, Waters AP, Nat Protoc 2006 1 346 356 10.1038/nprot.2006.53 17406255
25. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Mueller AK, Camargo N, Kaiser K, Andorfer C, Frevert U, Matuschewski K, Kappe SH, Proc Natl Acad Sci U S A 2005 102 8 3022 3027 10.1073/pnas.0408442102 15699336 (Pubitemid 40299909)
26. Improving cognitive outcome in cerebral malaria: insights from clinical and experimental research. De Miranda AS, Brant F, Machado FS, Rachid MA, Teixeira AL, Cent Nerv Syst Agents Med Chem. 2011 1 4 285 295
27. In vivo gene silencing in Plasmodium berghei - a mouse malaria model. Mohmmed A, Dasaradhi PV, Bhatnagar RK, Chauhan VS, Malhotra P, Biochem Biophys Res Commun 2003 309 3 506 511 26 10.1016/j.bbrc.2003.08.027 12963018 (Pubitemid 37083280)
28. Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2. Tong Y, Park I, Hong BS, Nedyalkova L, Tempel W, Park HW, Proteins 2009 75 4 1040 1050 10.1002/prot.22378 19280598
29. Spermidine metabolism in parasitic protozoa- a comparison to the situation in prokaryotes, plants and fungi. Kaiser AE, Gottwald AM, Wiersch CS, Maier WA, Seitz HM, Folia Parasitol. (Praha) 2003 50 1 3 18 (Pubitemid 36521951)
30. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Pain A, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell S, Rajandream MA, Carucci DJ, Yates JR, Kafatos FC, Janse CJ, Barrel B, Turner CM, Waters AP, Sinden RE, Science 2005 30 5706 82 86 (Pubitemid 40093481)
31. Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling. Templin AT, Maier B, Nishiki Y, Tersey SA, Mirmira RG, Cell Cycle 2011 10 7 1043 1049 10.4161/cc.10.7.15206 21389784
32. Impaired nitric oxide bioavailability and L-arginine-reversible endothelial dysfunction in adults with falciparum malaria. Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, McNeil YR, Darcy CJ, Granger DL, Weinberg JB, Lopansri BK, Price RN, Duffull SB, Celermajer DS, Anstey NM, J. Exp. Med. 2007 204 2693 2704 10.1084/jem.20070819 17954570 (Pubitemid 350044792)
33. Crystal structure of arginase from and implications for L-arginine depletion in malarial infection. Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW, Biochemistry 2010 49 (26 5600 5608 6 20527960
34. A rapid and sensitive for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Bradford MM, Analytical Biochem. 1976 72 248 254 10.1016/0003-2697(76)90527-3
35. Protocols for the preparation of blood plasma and serum, www.proimmune.com