Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4310-4313

  González Sabín, Javier ^a   Núñez, Luz Elena ^a   Menéndez, Nuria ^a   Braña, Alfredo F ^b   Méndez, Carmen ^b   Salas, José A ^b   Gotor, Vicente ^c   Morís, Francisco ^a  

^a Campus El Cristo ^*  (Spain)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Aureolic acid; Chromomycin A3; Enzymatic catalysis; Lipase; Regioselective acylation

Indexed keywords

AGLYCONE; ANTINEOPLASTIC AGENT; CHROMOMYCIN A3; CHROMOMYCIN A3 4' VINYLADIPATE; HYDROXYL GROUP; LIPASE B; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCATALYST; CANDIDA ANTARCTICA; CATALYSIS; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; STRUCTURE ANALYSIS;

ACYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CANDIDA; CELL LINE, TUMOR; CHROMOMYCIN A3; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIPASE; MICE; NIH 3T3 CELLS; STEREOISOMERISM;

CANDIDA ANTARCTICA;

EID: 84862156277     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.015     Document Type: Article

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