A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition

European Journal of Immunology

Volumn 42, Issue 6, 2012, Pages 1562-1572

  Kawano, Hiroki ^a   Katayama, Yoshio ^a   Minagawa, Kentaro ^a   Shimoyama, Manabu ^a   Henkemeyer, Mark ^b   Matsui, Toshimitsu ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Biphasic modulation EphB Ephrin B TCR

Indexed keywords

EPHRIN B1; EPHRIN B2; EPHRIN B3; GAMMA INTERFERON; INTERLEUKIN 2; PROTEIN KINASE B; PROTEIN KINASE LCK; PROTEIN TYROSINE PHOSPHATASE SHP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CELL SURVIVAL; CYTOKINE PRODUCTION; FEEDBACK SYSTEM; LYMPHOCYTE PROLIFERATION; MICROENVIRONMENT; MOLECULAR INTERACTION; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPHRIN-B1; EPHRIN-B2; FEEDBACK, PHYSIOLOGICAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RECEPTOR, EPHB3; RECEPTOR, EPHB4; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84862148423     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142175     Document Type: Article

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