Organizing the thymus gland: The role of Eph and ephrins

Annals of the New York Academy of Sciences

Volumn 1153, Issue , 2009, Pages 14-19

  Muñoz, Juan José ^a   García Ceca, Javier ^a   Alfaro, David ^a   Stimamiglio, Marco Augusto ^b   Cejalvo, Teresa ^a   Jiménez, Eva ^a   Zapata, Agustín G ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Eph; Ephrins; Thymic epithelial cells; Thymocytes

Indexed keywords

EPHRIN; EPHRIN B2; EPHRIN RECEPTOR; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B3;

CELL INTERACTION; CELL MATURATION; CELL STRUCTURE; CONFERENCE PAPER; EPITHELIUM CELL; HUMAN; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; ONTOGENY; ORGANOGENESIS; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 60349121520     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03965.x     Document Type: Conference Paper

References (23)

1. Mentlein, R. & M.D. Kendall. 2000. The brain and thymus have much in common: a functional analysis of their microenvironments. Immunol. Today 21 : 133 140.
2. Goldshmit, Y., S. McLenachan & A. Turnley. 2006. Roles of Eph receptors and ephrins in the normal and damaged adult CNS. Brain Res. Brain Res. Rev. 52 : 327 345.
3. Pasquale, E.B. 2008. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133 : 38 52.
4. Pasquale, E.B. 2005. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6 : 462 475.
5. Munoz, J.J. et al. 2002. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus. J. Immunol. 169 : 177 184.
6. Vergara-Silva, A., K.L. Schaefer & L.J. Berg. 2002. Compartmentalized Eph receptor and ephrin expression in the thymus. Mech. Dev. 119 (Suppl 1 S225 229.
7. Wu, J. & H. Luo. 2005. Recent advances on T-cell regulation by receptor tyrosine kinases. Curr. Opin. Hematol. 12 : 292 297.
8. Alfaro, D. et al. 2008. Alterations in the thymocyte phenotype of EphB-deficient mice largely affect the double negative cell compartment. Immunology 125 1 131 143.
9. Luo, H. et al. 2004. EphB6-null mutation results in compromised T cell function. J. Clin. Invest. 114 : 1762 1773.
10. Shimoyama, M. et al. 2002. Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice. Biochem. Biophys. Res. Commun. 298 : 87 94.
11. Coles, M.C. et al. 2004. The role of Eph receptors and ephrins ligands in T-cell development in the thymus. 12th Int. Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23. Clin Invest Med56D.
12. Yu, G. et al. 2004. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J. Biol. Chem. 279 : 55531 55539.
13. Yu, G. et al. 2006. Ephrin-B1 is critical in T-cell development. J. Biol. Chem. 281 : 10222 10229.
14. Munoz, J.J. et al. 2006. Thymic alterations in EphA4-deficient mice. J. Immunol. 177 : 804 813.
15. Manley, N.R. & C.C. Blackburn. 2003. A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from? Curr. Opin. Immunol. 15 : 225 232.
16. Rodewald, H.R. 2008. Thymus organogenesis. Annu. Rev. Immunol. 26 : 355 388.
17. Blackburn, C.C. & N.R. Manley. 2004. Developing a new paradigm for thymus organogenesis. Nat. Rev. Immunol. 4 : 278 289.
18. Blackburn, C.C. et al. 1996. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors. Proc. Natl. Acad. Sci. USA 93 : 5742 5746.
19. Balciunaite, G. et al. 2002. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat. Immunol. 3 : 1102 1108.
20. Su, D.M. et al. 2003. A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation. Nat. Immunol. 4 : 1128 1135.
21. Sharfe, N. et al. 2008. EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions. Mol Immunol. 45 : 1208 1220.
22. Sharfe, N. et al. 2002. Ephrin stimulation modulates T cell chemotaxis. Eur. J. Immunol. 32 : 3745 3755.
23. Alfaro, D. et al. 2007. EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development. Eur. J. Immunol. 37 : 2596 2605.