Shp2 function in hematopoietic stem cell biology and leukemogenesis

Current Opinion in Hematology

Volumn 19, Issue 4, 2012, Pages 273-279

  Nabinger, Sarah C ^a   Chan, Rebecca J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

hematopoietic stem cell; leukemogenesis; PTPN11; Shp2

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE SHP 2;

ACUTE LEUKEMIA; APOPTOSIS; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IN VIVO STUDY; LEUKEMOGENESIS; MYELOPROLIFERATIVE DISORDER; NOONAN SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; LEUKEMIA, MYELOID, ACUTE; MODELS, ANIMAL; MYELOPROLIFERATIVE DISORDERS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11;

EID: 84862137725     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328353c6bf     Document Type: Review

References (39)

1. Freeman RM Jr, Plutzky J, Neel BG. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci USA 1992; 89:11239-11243.
2. Feng GS, Hui CC, Pawson T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 1993; 259:1607-1611. (Pubitemid 23114639)
3. Feng GS. Shp-2 tyrosine phosphatase: signaling one cell or many. Exp Cell Res 1999; 253:47-54.
4. Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 2003; 28:284-293. (Pubitemid 36776291)
5. Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood 2007; 109:862-867. (Pubitemid 46220628)
6. Xu D, Qu CK. Protein tyrosine phosphatases in the JAK/STAT pathway. Front Biosci 2008; 13:4925-4932. (Pubitemid 351599646)
7. Liu X, Qu CK. Protein tyrosine phosphatase SHP-2 (PTPN11) in hematopoiesis and leukemogenesis. J Signal Transduct 2011:195239.
8. Kontaridis MI, Swanson KD, David FS, et al. PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem 2006; 281:6785-6792. (Pubitemid 43847615)
9. Stewart RA, Sanda T, Widlund HR, et al. Phosphatase-dependent and-independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell 2010; 18:750-762.
10. Tartaglia M, Mehler EL, Goldberg R, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet 2001; 29:465-468. (Pubitemid 34326699)
11. Qu CK, Shi ZQ, Shen R, et al. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol 1997; 17:5499-5507. (Pubitemid 27357646)
12. Qu CK, Yu WM, Azzarelli B, et al. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol 1998; 18:6075-6082. (Pubitemid 28450558)
13. Chan RJ, Johnson SA, Li Y, et al. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood 2003; 102:2074-2080. (Pubitemid 37122382)
14. Chan RJ, Li Y, Hass MN, et al. Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal. Exp Hematol 2006; 34:1230-1239.
15. Saxton TM, Henkemeyer M, Gasca S, et al. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J 1997; 16:2352-2364. (Pubitemid 27258636)
16. Zhang SQ, Yang W, Kontaridis MI, et al. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell 2004; 13:341-355. (Pubitemid 38229807)
17. Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 2004; 101:16064-16069. (Pubitemid 39507927)
18. Chan G, Cheung LS, Yang W, et al. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood 2011; 117:4253-4261.
19. Zhu HH, Ji K, Alderson N, et al. Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 2011; 117:5350-5361.
20. Zhang L, Friedman AD. SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis. Blood 2011; 118:2266-2274.
21. Li L, Modi H, McDonald T, et al. A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. Blood 2011; 118:1504-1515.
22. Tartaglia M, Niemeyer CM, Fragale A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34:148-150. (Pubitemid 36666923)
23. Loh ML, Reynolds MG, Vattikuti S, et al. PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group. Leukemia 2004; 18:1831-1834. (Pubitemid 39530013)
24. Bentires-Alj M, Paez JG, David FS, et al. Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res 2004; 64:8816-8820. (Pubitemid 39665483)
25. Tartaglia M, Martinelli S, Iavarone I, et al. Somatic PTPN11 mutations in childhood acute myeloid leukaemia. Br J Haematol 2005; 129:333-339. (Pubitemid 40646891)
26. Loh ML, Martinelli S, Cordeddu V, et al. Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leuk Res 2005; 29:459-462. (Pubitemid 40255821)
27. Tartaglia M, Martinelli S, Cazzaniga G, et al. Genetic evidence for lineagerelated and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Blood 2004; 104:307-313. (Pubitemid 38900008)
28. Johan MF, Bowen DT, Frew ME, et al. Mutations in PTPN11 are uncommon in adult myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 2004; 124:843-844. (Pubitemid 38365793)
29. Watkins F, Fidler C, Boultwood J, Wainscoat JS. Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia. Am J Hematol 2004; 76:417. (Pubitemid 38988633)
30. Christiansen DH, Desta F, Andersen MK, Pedersen-Bjergaard J. Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations. Genes Chromosomes Cancer 2007; 46:517-521. (Pubitemid 46649566)
31. Konieczna I, Horvath E, Wang H, et al. Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia. J Clin Invest 2008; 118:853-867. (Pubitemid 351364594)
32. Wang H, Lindsey S, Konieczna I, et al. Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia. J Biol Chem 2009; 284:2549-2567.
33. Xu R, Yu Y, Zheng S, et al. Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia. Blood 2005; 106:3142-3149. (Pubitemid 41565912)
34. Araki T, Mohi MG, Ismat FA, et al. Mouse model of Noonan syndrome reveals cell type-and gene dosage-dependent effects of Ptpn11 mutation. Nat Med 2004; 10:849-857. (Pubitemid 39070859)
35. Xu D, Wang S, Yu WM, et al. A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells. Blood 2010; 116:3611-3621.
36. Chan G, Kalaitzidis D, Usenko T, et al. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 2009; 113:4414-4424.
37. Xu D, Liu X, Yu WM, et al. Nonlineage/stage-restricted effects of a gain-offunction mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 2011; 208:1977-1988.
38. Keilhack H, David FS, McGregor M, et al. Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J Biol Chem 2005; 280:30984-30993. (Pubitemid 41291831)
39. Mohi MG, Williams IR, Dearolf CR, et al. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell 2005; 7:179-191. (Pubitemid 40248343)