Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia

American Journal of Hematology

Volumn 76, Issue 4, 2004, Pages 417-

  Watkins, Fiona ^a   Fioler, Carrie ^a   Boultwood, Jacqueline ^a   Wainscoat, James S ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE SHP 2;

ACUTE GRANULOCYTIC LEUKEMIA; GENE MUTATION; GENE SEQUENCE; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; LETTER; MONOSOMY 7; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PTPN11 GENE;

ACUTE DISEASE; ADULT; AGE FACTORS; CHILD; CHROMOSOMES, HUMAN, PAIR 7; DNA MUTATIONAL ANALYSIS; EXONS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOID; MONOSOMY; MYELODYSPLASTIC SYNDROMES; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 3343005287     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20134     Document Type: Letter

References (4)

1. Neel BG. Structure and function of SH2-domain containing tyrosine phosphatases. Semin Cell Biol 1993;4:419-432.
2. Cunnick JM, Meng S, Ren Y, et al. Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J Biol Chem 2002;277:9498-9504.
3. Tartaglia M, Niemeyer CM, Fragal A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukaemia, myelodysplastic syndromes and acute myeloid leukaemia. Nat Genet 2003;63:423-426.
4. Tartaglia M, Niemeyer CM, Shannon KM, Loh ML. SHP-2 and myeloid malignancies. Curr Opin Hematol 2004;11:44-50.