Metabolic activity in external and internal awareness networks in severely brain-damaged patients

Journal of Rehabilitation Medicine

Volumn 44, Issue 6, 2012, Pages 487-494

  Thibaut, Aurore ^a   Bruno, Marie Aurélie ^a   Chatelle, Camille ^a   Gosseries, Olivia ^a   Vanhaudenhuyse, Audrey ^a   Demertzi, Athena ^a   Schnakers, Caroline ^a   Thonnard, Marie ^a   Charland Verville, Vanessa ^a   Bernard, Claire ^a   Ali Bahri, Mohammed ^a   Phillips, Christophe ^b   Boly, Mélanie ^a   Hustinx, Roland ^a   Laureys, Steven ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Consciousness; Minimally conscious state; Positron emission tomography; Self awareness; Traumatic brain injury; Vegetative state

Indexed keywords

DIAGNOSTIC AGENT; FLUORODEOXYGLUCOSE F 18;

ADOLESCENT; ADULT; AGED; ARTICLE; AWARENESS; BRAIN; BRAIN INJURY; COMA; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PERSISTENT VEGETATIVE STATE; POSITRON EMISSION TOMOGRAPHY; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AWARENESS; BRAIN; BRAIN INJURIES; COMA; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; PERSISTENT VEGETATIVE STATE; POSITRON-EMISSION TOMOGRAPHY; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84862127721     PISSN: 16501977     EISSN: None     Source Type: Journal    
DOI: 10.2340/16501977-0940     Document Type: Article

References (55)

1. Schnakers C, Vanhaudenhuyse A, Giacino J, Ventura M, Boly M, Majerus S, et al. Diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment. BMC Neurol 2009; 9: 35.
2. Zeman A. Consciousness. Brain 2001; 124: 1263-1289. (Pubitemid 32606089)
3. Vanhaudenhuyse A, Demertzi A, Schabus M, Noirhomme Q, Bredart S, Boly M, et al. Two distinct neuronal networks mediate the awareness of environment and of self. J Cogn Neurosci 2011; 23: 570-578.
4. Majerus S, Gill-Thwaites H, Andrews K, Laureys S. Behavioral evaluation of consciousness in severe brain damage. Prog Brain Res 2005; 150: 397-413. (Pubitemid 41381566)
5. Laureys S, Celesia GG, Cohadon F, Lavrijsen J, Leon-Carrion J, Sannita WG, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med 2010; 8: 68.
6. Giacino J, Ashwal S, Childs N, Cranford R, Jennett B, Katz D, et al. The minimally conscious state: definition and diagnostic criteria. Neurology 2002; 58: 349-353. (Pubitemid 34150906)
7. American Congress of Rehabilitation Medicine Recommendations for use of uniform nomenclature pertinent to patients with severe alterations of consciousness Arch Phys Med Rehabil 1995; 76: 205-209.
8. Gosseries O, Bruno M, Chatelle C, Vanhaudenhuyse A, Schnakers C, Soddu A, et al. Disorders of consciousness: what's in a name? NeuroRehabilitation 2011; 28: 3-14.
9. Bruno M, Gosseries O, Ledoux D, Hustinx R, Laureys S. Assessment of consciousness with electrophysiological and neurological and neurological imaging techniques. Curr Opin Crit Care 2011; 17: 146-151.
10. Majerus S, Bruno MA, Schnakers C, Giacino JT, Laureys S. The problem of aphasia in the assessment of consciousness in braindamaged patients. Prog Brain Res 2009; 177: 49-61.
11. Bruno M-A, Fernández-Espejo D, Lehembre R, Tshibanda L, Vanhaudenhuyse A, Gosseries O, et al. Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". Prog Brain Res 2011; 193: 323-333.
12. Bruno M, Ledoux D, Lambermont B, Damas F, Laureys S. Comparison of the Full Outline of Responsiveness (FOUR), the Glasgow Coma Scale (GCS) and the Glasgow Liège Scale (GLS) in an intensive care unit population. Neurocrit Care 2011; 15: 447-453.
13. Schnakers C, Giacino J, Kalmar K, Piret S, Lopez E, Boly M, et al. Does the FOUR score correctly diagnose the vegetative and minimaly conscious states? Ann Neurol 2006; 60: 744-745. (Pubitemid 46048491)
14. Giacino J, Kalmar K, Whyte J. The JFK Coma Recovery Scalerevised. Arch Phys Med Rehabil 2004; 85: 2020-2029.
15. Vanhaudenhuyse A, Schnakers C, Brédart S, Laureys S. Assessment of visual pursuit in post-comatose states: use a mirror. J Neurol Neurosurg Psychiatry 2008; 79: 223. (Pubitemid 351236565)
16. Shiel A, Horn S, Wilson B, Watson M, Campbell M, McLellan D. The Wessex Head Injury Matrix (WHIM) main scale: a preliminary report on a scale to assess monitor patient recovery after severe head injury. Clin Rehabil 2000; 14: 408-416. (Pubitemid 30488758)
17. Laureys S, Perrin F, Brédart S. Self-consciousness in non-communicative patients. Conscious Cogn 2007; 16: 722-741. (Pubitemid 47505317)
18. Baars B, Ramsoy T, Laureys S. Brain, conscious experience and the observing self. Trends Neurosci 2003; 26: 671-675. (Pubitemid 37415018)
19. Dehaene S, Naccache L. Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework. Cognition 2001; 79: 1-37. (Pubitemid 32054795)
20. Laureys S. The neural correlate of (un)awareness: lessons from the vegetative state. Trends Cogn Sci 2005; 9: 556-559. (Pubitemid 41677486)
21. The Multi-Society Task Force on PVS. Medical aspects of the persistent vegetative state. N Engl J Med 1994; 330: 1499-1508.
22. Giacino JT. Disorders of consciousness: differential diagnosis and neuropathologic features. Semin Neurol 1997; 17: 105-111. (Pubitemid 27263678)
23. Laureys S, Faymonville M, Moonen G, Luxen A, Maquet P. PET scanning and neuronal loss in acute vegetative state. Lancet 2000; 355: 1825-1826.
24. Laureys S. Functional neuroimaging in the vegetative state. NeuroRehabilitation 2004; 19: 335-341. (Pubitemid 40202525)
25. Laureys S, Lemaire C, Maquet P, Phillips C, Franck G. Cerebral metabolism during vegetative state and after recovery to consciousness. J Neurol Neurosurg Psychiatry 1999; 67: 121. (Pubitemid 29278345)
26. Bruno M, Vanhaudenhuyse A, Schnakers C, Boly M, Gosseries O, Demertzi A, et al. Visual fixation in the vegetative state: an observational case series PET study. BMC Neurol 2010; 10: 35.
27. Phillips C, Bruno M, Maquet P, Boly M, Noirhomme Q, Schnakers C, et al. "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. Neuroimage 2011; 56: 797-808.
28. Laureys S, Goldman S, Phillips C, Van Bogaert P, Aert J, Luxen A, et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. Neuroimage 1999; 9: 377-382. (Pubitemid 29369857)
29. Nakayama N, Okumura A, Shinoda J, Nakashima T, Iwama T. Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis. JNNP 2006; 77: 856-862. (Pubitemid 44023181)
30. Juengling F, Kassubek J, Huppertz H, Krause T, Els T. Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET. J Neurol Sci 2005; 228: 179-184. (Pubitemid 40202964)
31. Boly M, Balteau E, Schnakers C, Degueldre C, Moonen G, Luxen A, et al. Baseline brain activity fluctuations predict somatosensory perception in humans. Proc Natl Acad Sci 2007; 104: 12187-12192. (Pubitemid 47185651)
32. Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C, Buchel C. Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single trial fMRI study. Brain 2002; 125: 1326-1336. (Pubitemid 34591096)
33. Fuhrmann A, Hein G, Tsai N, Naumer M, Knight R. Temporal characteristic of audiovisual information processing. J Neurosci 2008; 28: 5344-5349.
34. Rees G. Neural correlates of the contents of visual awareness in humans. Philos Trans R Soc Lond Biol Sci 2007; 362:877-886. (Pubitemid 47056816)
35. Sergent C, Dehaene S. Neural process underlying conscious perception: experimental findings and global neuronal workspace framework. J Physiol Paris 2004; 98: 374-384. (Pubitemid 41750990)
36. Vanhaudenhuyse A, Giacino J, Schnakers C, Kalmar K, Smart C, Bruno M, et al. Blink to visual threat does not herald consciousness in the vegetative state. Neurology 2008; 71: 1374-1375.
37. Mason M, Norton M, Van Horn J, Wegner D, Grafton S, Marcrae C. Wandering minds: the default network and stimulus-independent thought. Science 2007; 315: 393-395. (Pubitemid 46175523)
38. Knauff M, Fangmeier T, Ruff C, Johnson-Laird P. Reasoning, models, and images: behavioral measures and cortical activity. J Cogn Neurosci 2003; 15: 559-573. (Pubitemid 36530090)
39. Lou H, Luber B, Crupain M, Keenan J, Nowak M, Kjaer T, et al. Parietal cortex and representation of mental self. Proc Natl Acad Sci 2004; 101: 6827-6832. (Pubitemid 38586059)
40. Goldberg I, Harel M, Malach R. When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 2006; 50: 329-339.
41. Raichle M, MacLeod A, Snyder A, Powers W, Gusnard D, Shulman G. A default mode of brain function. Proc Natl Acad Sci 2001; 98: 676-682. (Pubitemid 32105102)
42. Boly M, Phillips C, Tshibanda J, Vanhaudenhuyse A, Schabus M, Dang-Vu T, et al. Intrinsic brain activity in altered states of consciousness: how consciousness is the default mode of brain function? Ann N Y Acad Sci 2008; 1129: 119-129. (Pubitemid 351990285)
43. Soddu A, Vanhaudenhuyse A, Bahri M, Bruno M, Boly M, Demertzi A, et al. Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Hum Brain Mapp 2011 Apr 11 doi: 10.1002/hbm.21249. [Epub ahead of print].
44. Lull N, Noé E, Lull J, Garcia-Panach J, Chirivella J, Ferri J, et al. Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition. Brain Inj 2010; 24:1098-1107.
45. Fernandez-Espejo D, Bekinschtein T, Monti M, Pickard J, Junque C, Coleman M, et al. Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state. Neuroimage 2010; 54: 103-112.
46. Graham D, Adams J, Murrays L, Jennet B. Neuropathology of vegetative state after head injury. Neuropsychol Rehabil 2005; 15: 198-213. (Pubitemid 41248328)
47. Cologan V, Schabus M, Ledoux D, Moonen G, Maquet P, Laureys S. Sleep in disorders of consciousness. Sleep Med Rev 2010; 14: 97-105.
48. Vogt B, Vogt L, Laureys S. Cytology and functionnally correlated circuits of human posterior cingulate areas. Neuroimage 2006; 29: 452-466. (Pubitemid 43063302)
49. Vogt B, Laureys S. Posterior cingulate, precuneal and retrospinal cortices: cytology and components of the neural network correlates of consciousness. Prog Brain Res 2005; 150: 205-217. (Pubitemid 41381554)
50. Machado C, Perez-Nellar J, Rodriguez R, Scherle C, Korein J. Emergence from minimally conscious state: insights from evaluation of posttraumatic confusion. Neurology 2009; 74: 1156.
51. Katz D, Polyak M, Coughlan D, Nichols M, Roche A. Natural history of recovery from brain injury after prolonged disorders of consciousness: outcome of patients admitted to inpatient rehabilitation with 1-4 year follow-up. Prog Brain Res 2009; 177: 73-88.
52. Laureys S, Owen A, Schiff N. Brain function in coma, vegetative state, and related disordres. Lancet Neurol. 2004; 3: 537-546. (Pubitemid 39485860)
53. Laureys S, Pellas F, Van Eeckhout P, Ghorbel S, Schnakers C, Perrin F, et al. The locked-in syndrome: what is it like to be conscious but paralysed and voiceless? Prog Brain Res 2005; 150: 495-511. (Pubitemid 41381572)
54. Schnakers C, Majerus S, Goldman S, Boly M, Van Eeckhout P, Gay S, et al. Cognitive function in the locked-in syndrome. J Neurol 2008; 255: 323-330.
55. Vanhaudenhuyse A, Noirhomme Q, Tshibanda J, Bruno M, Ledoux D, Brichant J, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010; 133: 161-171.