Design optimization of liquid-phase flow patterns for microfabricated lung on a chip

Annals of Biomedical Engineering

Volumn 40, Issue 6, 2012, Pages 1255-1267

  Long, C ^a   Finch, C ^a   Esch, M ^b   Anderson, W ^a   Shuler, M ^b   Hickman, J ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b Cornell University   (United States)

Author keywords

Bioreactor; Computational fluid dynamics; Modeling; Plug flow; Residence time distribution; Simulation; Transport; Visualization

Indexed keywords

BROAD APPLICATION; CELL CONSTRUCTS; CIRCULAR CHAMBER; COMPUTATIONAL FLUID DYNAMICS SIMULATIONS; DESIGN OPTIMIZATION; ENGINEERED SYSTEMS; HYBRID DESIGN; HYBRID OPTIMIZATION; IN-VITRO; LIQUID PHASE; MICRO FLUIDIC SYSTEM; MICRO REACTOR; MICROFABRICATED; MICROFLUIDIC STRUCTURES; NO-SLIP BOUNDARY CONDITIONS; PLUG FLOW; QUANTITATIVE VISUALIZATION; RESIDENCE TIME DISTRIBUTIONS; SIMULATION; STAGNATION ZONES; TRANSPORT;

BIOLOGICAL ORGANS; BIOREACTORS; COMPUTATIONAL FLUID DYNAMICS; EXPERIMENTS; FLOW VISUALIZATION; FLUIDIC DEVICES; MODELS; MOLTEN MATERIALS; PIPE FLOW; TISSUE; VISUALIZATION;

OPTIMIZATION;

ANIMAL; ARTICLE; ARTIFICIAL MEMBRANE; BIOREACTOR; HUMAN; INSTRUMENTATION; LUNG; METHODOLOGY; MICROFLUIDIC ANALYSIS;

ANIMALS; BIOREACTORS; HUMANS; LUNG; MEMBRANES, ARTIFICIAL; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 84862120544     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-012-0513-8     Document Type: Article

References (25)

1. JT Adeosun A Lawal 2009 Numerical and experimental studies of mixing characteristics in a T-junction microchannel using residence-time distribution Chem. Eng. Sci. 64 2422 2432 10.1016/j.ces.2009.02.013 1:CAS:528: DC%2BD1MXksVCrsbY%3D
2. CJ Campbell BA Grzybowski 2004 Microfluidic mixers: from microfabricated to self-assembling devices Philos. Trans. R. Soc. Lond. Ser. A 362 1069 1086 10.1098/rsta.2003.1363 (Pubitemid 38652648)
3. A Cantu-Perez S Barrass A Gavriilidis 2010 Residence time distributions in microchannels: comparison between channels with herringbone structures and a rectangular channel Chem. Eng. J. 160 834 844 10.1016/j.cej.2009.07.023 1:CAS:528:DC%2BC3cXmslOjt70%3D
4. S Carlotto I Fortunati C Ferrante P Schwille A Polimeno 2011 Time correlated fluorescence characterization of an asymmetrically focused flow in a microfluidic device Microfluid. Nanofluid. 10 551 561 10.1007/s10404-010-0689-x
5. CT Culbertson SC Jacobson J Michael Ramsey 2002 Diffusion coefficient measurements in microfluidic devices Talanta 56 365 373 18968508 10.1016/S0039-9140(01)00602-6 1:CAS:528:DC%2BD38XpvVaitw%3D%3D (Pubitemid 34145960)
6. AJ DeMello 2006 Control and detection of chemical reactions in microfluidic systems Nature 442 394 402 16871207 10.1038/nature05062 1:CAS:528:DC%2BD28XnsVaju7o%3D (Pubitemid 44264783)
7. D Dutta A Ramachandran D Leighton 2006 Effect of channel geometry on solute dispersion in pressure-driven microfluidic systems Microfluid. Nanofluid. 2 275 290 10.1007/s10404-005-0070-7 (Pubitemid 43950764)
8. MB Esch TL King ML Shuler 2011 The role of body-on-a-chip devices in drug and toxicity studies Annu. Rev. Biomed. Eng. 13 55 72 21513459 10.1146/annurev-bioeng-071910-124629 1:CAS:528:DC%2BC3MXhtFCit7zK
9. A Günther M Jhunjhunwala M Thalmann MA Schmidt KF Jensen 2005 Micromixing of miscible liquids in segmented gas-liquid flow Langmuir 21 1547 1555 15697306 10.1021/la0482406 (Pubitemid 40275094)
10. RL Hartman JP McMullen KF Jensen 2011 Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis Angew. Chem. Int. Ed. Engl. 50 7502 7519 21710673 10.1002/anie.201004637 1:CAS:528: DC%2BC3MXotVCns74%3D
11. V Hessel H Löwe F Schönfeld 2005 Micromixers-a review on passive and active mixing principles Chem. Eng. Sci. 60 2479 2501 10.1016/j.ces.2004.11.033 1:CAS:528:DC%2BD2MXitVaitLo%3D (Pubitemid 40306800)
12. CH Hornung MR Mackley 2009 The measurement and characterisation of residence time distributions for laminar liquid flow in plastic microcapillary arrays Chem. Eng. Sci. 64 3889 3902 10.1016/j.ces.2009.05.033 1:CAS:528:DC%2BD1MXptVGhs7w%3D
13. D Huh BD Matthews A Mammoto M Montoya-Zavala HY Hsin DE Ingber 2010 Reconstituting organ-level lung functions on a chip Science 328 1662 1668 20576885 10.1126/science.1188302 1:CAS:528:DC%2BC3cXnvVekur0%3D
14. MK Inglesby SH Zeronian 2001 Diffusion coefficients for direct dyes in aqueous and polar aprotic solvents by the NMR pulsed-field gradient technique Dyes Pigments 50 3 11 10.1016/S0143-7208(01)00035-3 1:CAS:528: DC%2BD3MXlt1Slu7c%3D (Pubitemid 32710681)
15. M Jamnongwong K Loubiere N Dietrich G Hébrard 2010 Experimental study of oxygen diffusion coefficients in clean water containing salt, glucose or surfactant: consequences on the liquid-side mass transfer coefficients Chem. Eng. J. 165 758 768 10.1016/j.cej.2010.09.040 1:CAS:528:DC%2BC3cXhsVynur%2FJ
16. I Kola J Landis 2004 Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 711 716 15286737 10.1038/nrd1470 1:CAS:528:DC%2BD2cXmtVOhtLs%3D
17. M Nakagaki 1950 The diffusion of dye solutions Bull. Chem. Soc. Jpn. 23 104 107 10.1246/bcsj.23.104 1:CAS:528:DyaG3MXitFSgtw%3D%3D
18. DE Powers JR Millman S Bonner-Weir MJ Rappel CK Colton 2010 Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation Biotechnol. Prog. 26 805 818 20039374 10.1002/btpr.359 1:CAS:528:DC%2BC3cXpsVKnurc%3D
19. Rasband, W. S. ImageJ. Bethesda, Maryland: U.S. National Institutes of Health, 1997-2011
20. G Ryu JS Huang O Hofmann CA Walshe JYY Sze GD McClean A Mosley SJ Rattle JC deMello AJ deMello DDC Bradley 2011 Highly sensitive fluorescence detection system for microfluidic lab-on-a-chip Lab Chip 11 1664 1670 21431240 10.1039/c0lc00586j 1:CAS:528:DC%2BC3MXksFSktLg%3D
21. H Song JD Tice RF Ismagilov 2003 A microfluidic system for controlling reaction networks in time Angew. Chem. Int. Ed. Engl. 115 792 796 10.1002/ange.200390172
22. J Sung M Shuler 2009 Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap Biomed. Microdevices 11 731 738 19212816 10.1007/s10544-009-9286-8
23. J Sung M Shuler 2010 In vitro microscale systems for systematic drug toxicity study Bioprocess. Biosyst. Eng. 33 5 19 19701779 10.1007/s00449-009- 0369-y 1:CAS:528:DC%2BD1MXhsFyjsLvK
24. A Tamimi EB Rinker OC Sandall 1994 Diffusion coefficients for hydrogen sulfide, carbon dioxide, and nitrous oxide in water over the temperature range 293-368 K J. Chem. Eng. Data 39 330 332 10.1021/je00014a031 1:CAS:528: DyaK2cXit1Oks70%3D
25. P Znidarsic-Plazl I Plazl 2007 Steroid extraction in a microchannel system-mathematical modelling and experiments Lab Chip 7 883 889 17594008 10.1039/b704432a 1:CAS:528:DC%2BD2sXmvV2mtr4%3D (Pubitemid 47000820)