메뉴 건너뛰기




Volumn 4, Issue 3, 2012, Pages 165-169

Antioxidant Activities and Cytotoxicity of Selected Coumarin Derivatives: Preliminary Results of a Structure-Activity Relationship Study Using Computational Tools

Author keywords

Anticancer; Antioxidant; Coumarin; In silico analysis

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; METHOTREXATE;

EID: 84862024864     PISSN: 18783317     EISSN: 18783325     Source Type: Journal    
DOI: 10.1016/j.jecm.2012.04.007     Document Type: Article
Times cited : (75)

References (28)
  • 2
    • 84883846728 scopus 로고
    • Naturally occurring coumarins and related physiological activities
    • Soine T.O. Naturally occurring coumarins and related physiological activities. J Pharm Sci 1964, 53:231.
    • (1964) J Pharm Sci , vol.53 , pp. 231
    • Soine, T.O.1
  • 3
    • 85010257330 scopus 로고    scopus 로고
    • John Wiley, Chichester, R. O'Kennedy, R.D. Thornes (Eds.)
    • Coumarins - biology, applications and mode of action 1997, 125-141. John Wiley, Chichester. R. O'Kennedy, R.D. Thornes (Eds.).
    • (1997) Coumarins - biology, applications and mode of action , pp. 125-141
  • 4
    • 0028060024 scopus 로고
    • Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins
    • Paya M., Goodwin P.A., De Las Heras B., Hoult R.S. Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins. Biochem Pharmacol 1994, 48:445-451.
    • (1994) Biochem Pharmacol , vol.48 , pp. 445-451
    • Paya, M.1    Goodwin, P.A.2    De Las Heras, B.3    Hoult, R.S.4
  • 5
    • 84862025848 scopus 로고    scopus 로고
    • Screening of plant coumarins
    • PhD thesis. Helsinki: University of Helsinki
    • Ojala T. Screening of plant coumarins, PhD thesis. Helsinki: University of Helsinki; 2001. p. 23-25.
    • (2001) , pp. 23-25
    • Ojala, T.1
  • 6
    • 6944237046 scopus 로고    scopus 로고
    • Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer
    • Lacy A., O'Kennedy R. Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. Current Pharma Des 2004, 10:3797-3811.
    • (2004) Current Pharma Des , vol.10 , pp. 3797-3811
    • Lacy, A.1    O'Kennedy, R.2
  • 7
    • 15944389028 scopus 로고    scopus 로고
    • Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity
    • Borges F., Roleira F., Milhazes N., Santana L., Uriarte E. Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity. Current Med Chem 2005, 12:887-916.
    • (2005) Current Med Chem , vol.12 , pp. 887-916
    • Borges, F.1    Roleira, F.2    Milhazes, N.3    Santana, L.4    Uriarte, E.5
  • 8
    • 0037784050 scopus 로고    scopus 로고
    • Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues
    • Budzisz E., Brzezinska E., Krajewska U., Rozalski M. Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues. Eur J Med Chem 2003, 38:597-603.
    • (2003) Eur J Med Chem , vol.38 , pp. 597-603
    • Budzisz, E.1    Brzezinska, E.2    Krajewska, U.3    Rozalski, M.4
  • 9
    • 0031966653 scopus 로고    scopus 로고
    • Studies on circadian periodicity of urinary corticoids in carcinoma of the breast
    • Singh R., Singh R.K., Mahdi A.A., Misra S., Rai S.P., Singh D., Cornelissen G., et al. Studies on circadian periodicity of urinary corticoids in carcinoma of the breast. In Vivo 1998, 12:69-73.
    • (1998) In Vivo , vol.12 , pp. 69-73
    • Singh, R.1    Singh, R.K.2    Mahdi, A.A.3    Misra, S.4    Rai, S.P.5    Singh, D.6    Cornelissen, G.7
  • 10
    • 0842264792 scopus 로고    scopus 로고
    • Circadian periodicity of plasma lipid peroxides and other antioxidants as putative markers in gynaecological malignancies
    • Singh R., Singh R.K., Mahdi A.A., Singh R.K., Kumar A., Tripathi A.K., Rai R., et al. Circadian periodicity of plasma lipid peroxides and other antioxidants as putative markers in gynaecological malignancies. In Vivo 2003, 17(6):593-600.
    • (2003) In Vivo , vol.17 , Issue.6 , pp. 593-600
    • Singh, R.1    Singh, R.K.2    Mahdi, A.A.3    Singh, R.K.4    Kumar, A.5    Tripathi, A.K.6    Rai, R.7
  • 11
    • 64749107801 scopus 로고    scopus 로고
    • Implications of free radicals and antioxidant levels in carcinoma of the breast: a never ending battle for survival
    • Sinha R.J., Singh R., Mehrotra S., Singh R.K. Implications of free radicals and antioxidant levels in carcinoma of the breast: a never ending battle for survival. Indian J Cancer 2009, 46(2):146-150.
    • (2009) Indian J Cancer , vol.46 , Issue.2 , pp. 146-150
    • Sinha, R.J.1    Singh, R.2    Mehrotra, S.3    Singh, R.K.4
  • 12
    • 3843083954 scopus 로고    scopus 로고
    • Synthesis and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives
    • Shih M.H., Ke F.Y. Synthesis and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. Bioorg Med Chem 2004, 12:4633-4643.
    • (2004) Bioorg Med Chem , vol.12 , pp. 4633-4643
    • Shih, M.H.1    Ke, F.Y.2
  • 13
    • 33746701367 scopus 로고    scopus 로고
    • Quantitative structure-cytotoxicity relationship analysis of coumarin and its derivatives by semiempirical molecular orbital method
    • Isihara M., Yoshiko Y., Sakagami H. Quantitative structure-cytotoxicity relationship analysis of coumarin and its derivatives by semiempirical molecular orbital method. Anticancer Res 2006, 26:2883-2886.
    • (2006) Anticancer Res , vol.26 , pp. 2883-2886
    • Isihara, M.1    Yoshiko, Y.2    Sakagami, H.3
  • 15
    • 0001728908 scopus 로고    scopus 로고
    • Quantum-chemical descriptors in QSAR/QSPR studies
    • Karelson M., Lobanov V.S. Quantum-chemical descriptors in QSAR/QSPR studies. Chem Rev 1996, 96:1027-1043.
    • (1996) Chem Rev , vol.96 , pp. 1027-1043
    • Karelson, M.1    Lobanov, V.S.2
  • 16
    • 0141904962 scopus 로고    scopus 로고
    • An AM1 study on the electron-donating and electron accepting character of biomolecules
    • Honorio K.M., Da Silva A.B.F. An AM1 study on the electron-donating and electron accepting character of biomolecules. Int J Quantum Chem 2003, 95(2):126-132.
    • (2003) Int J Quantum Chem , vol.95 , Issue.2 , pp. 126-132
    • Honorio, K.M.1    Da Silva, A.B.F.2
  • 17
    • 0025981233 scopus 로고
    • About the mutagenicity of chlorine-substituted furanones and halopropenals - a QSAR study using molecular orbital indexes
    • Tuppurainen K., Lotjonen S., Laatikainen R., Vartiainen T., Maran U., Strandberg M., Tamm T. About the mutagenicity of chlorine-substituted furanones and halopropenals - a QSAR study using molecular orbital indexes. Mutat Res 1991, 247:97-202.
    • (1991) Mutat Res , vol.247 , pp. 97-202
    • Tuppurainen, K.1    Lotjonen, S.2    Laatikainen, R.3    Vartiainen, T.4    Maran, U.5    Strandberg, M.6    Tamm, T.7
  • 18
    • 33947332005 scopus 로고
    • Application of the principle of hard and soft acids and bases to organic chemistry
    • Pearson R.G., Songstad J. Application of the principle of hard and soft acids and bases to organic chemistry. J Amer Chem Soc 1967, 89:1827-1836.
    • (1967) J Amer Chem Soc , vol.89 , pp. 1827-1836
    • Pearson, R.G.1    Songstad, J.2
  • 19
    • 73749086579 scopus 로고    scopus 로고
    • Physicochemical characteristics that influence the transport of drugs across intestinal barrier
    • Vemulapalli V., Ghilzai N.M., Jasti B.R. Physicochemical characteristics that influence the transport of drugs across intestinal barrier. AAPS Newsmagazine 2007, 18-21.
    • (2007) AAPS Newsmagazine , pp. 18-21
    • Vemulapalli, V.1    Ghilzai, N.M.2    Jasti, B.R.3
  • 20
    • 65249097797 scopus 로고    scopus 로고
    • Aqueous solubility prediction based on weighted atom type counts and solvent accessible surface areas
    • Wang J., Hou T., Xu X. Aqueous solubility prediction based on weighted atom type counts and solvent accessible surface areas. J Chem Inf Model 2009, 49:571-581.
    • (2009) J Chem Inf Model , vol.49 , pp. 571-581
    • Wang, J.1    Hou, T.2    Xu, X.3
  • 21
    • 0030176193 scopus 로고    scopus 로고
    • Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential
    • Hoult J., Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996, 27:713-722.
    • (1996) Gen Pharmacol , vol.27 , pp. 713-722
    • Hoult, J.1    Paya, M.2
  • 22
    • 33646085011 scopus 로고    scopus 로고
    • Coumarin derivatives and antioxidative stress
    • Traykova M., Kostova I. Coumarin derivatives and antioxidative stress. Int J Pharmacol 2005, 1:29-32.
    • (2005) Int J Pharmacol , vol.1 , pp. 29-32
    • Traykova, M.1    Kostova, I.2
  • 23
    • 74149094268 scopus 로고    scopus 로고
    • Umbeliferone: an antioxidant isolated from Acacia nilotica(L.) Willd
    • Singh R., Singh B., Singh S., Kumar N., Arora S. Umbeliferone: an antioxidant isolated from Acacia nilotica(L.) Willd. Ex Del Food Chem 2010, 120:825-830.
    • (2010) Ex Del Food Chem , vol.120 , pp. 825-830
    • Singh, R.1    Singh, B.2    Singh, S.3    Kumar, N.4    Arora, S.5
  • 24
    • 0028233005 scopus 로고
    • Antitumor activity of coumarin and 7-hydroxycoumarin against 7, 12-dimethylbenzanthracene induced rat mammary carcinomas
    • Maucher A., von Angerer E. Antitumor activity of coumarin and 7-hydroxycoumarin against 7, 12-dimethylbenzanthracene induced rat mammary carcinomas. J Cancer Res Clin Oncol 1994, 120:502-504.
    • (1994) J Cancer Res Clin Oncol , vol.120 , pp. 502-504
    • Maucher, A.1    von Angerer, E.2
  • 27
    • 0028838229 scopus 로고
    • Toxicity of dioxins: role of absolute hardness-absolute electronegativity (η-χ diagram) as a new measure in risk assessment
    • Kobayashi S., Sameshima K., Ishii Y., Tanaka A. Toxicity of dioxins: role of absolute hardness-absolute electronegativity (η-χ diagram) as a new measure in risk assessment. Chem Pharm Bull 1995, 43:1780-1790.
    • (1995) Chem Pharm Bull , vol.43 , pp. 1780-1790
    • Kobayashi, S.1    Sameshima, K.2    Ishii, Y.3    Tanaka, A.4
  • 28
    • 0031853138 scopus 로고    scopus 로고
    • Hardness controlled enzymes and electronegativity controlled enzymes: role of an absolute hardness- electronegativity (η-χ) activity diagram as a coordinate for biological activities
    • Kobayashi S., Hamashima H., Kurihara M., Miyata N., Tanaka A. Hardness controlled enzymes and electronegativity controlled enzymes: role of an absolute hardness- electronegativity (η-χ) activity diagram as a coordinate for biological activities. Chem Pharm Bull 1998, 46:1108-1115.
    • (1998) Chem Pharm Bull , vol.46 , pp. 1108-1115
    • Kobayashi, S.1    Hamashima, H.2    Kurihara, M.3    Miyata, N.4    Tanaka, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.