Hardness controlled enzymes and electronegativity controlled enzymes: Role of an absolute hardness-electronegativity (η-χ) activity diagram as a coordinate for biological activities

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 7, 1998, Pages 1108-1115

  Kobayashi, Shigeki ^a   Hamashima, Hajime ^a   Kurihara, Masaaki ^b   Miyata, Naoki ^b   Tanaka, Akira ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Biological activity; Dioxin; Flew quinolone; Hardness concept; PCB; activity diagram

Indexed keywords

1,4 DIHYDRO 4 OXO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; 1,8 NAPHTHYRIDINE DERIVATIVE; 4 OXO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID DERIVATIVE; 4 OXO 3 QUINOLINECARBOXYLIC ACID DERIVATIVE; ANTIINFECTIVE AGENT; CARBOXYLIC ACID DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENOXACIN; ENZYME; GYRASE INHIBITOR; NORFLOXACIN; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; ELECTRIC ACTIVITY; ESCHERICHIA COLI; HARDNESS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 0031853138     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1108     Document Type: Article

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