Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships

Life Sciences

Volumn 90, Issue 23-24, 2012, Pages 929-933

  Yang, Zhong Duo ^a   Duan, Dong Zhu ^a   Xue, Wei Wei ^b   Yao, Xiao Jun ^b   Li, Shuo ^c  

^a LANZHOU UNIVERSITY OF TECHNOLOGY   (China)

^b LANZHOU UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Acetylcholinesterase inhibitor; Alzheimer's disease; Conessimin; Holarrhena antidysenterica; Steroidal alkaloids; Structure activity relationships

Indexed keywords

ALKALOID; CHOLINESTERASE INHIBITOR; CONARRHIMIN; CONESSIMIN; CONESSINE; CONIMIN; HOLARRHENA ANTIDYSENTERICA EXTRACT; HOOKERIANAMIDE F; HUPERZINE A; ISOCONESSIMINE; PHYTOSTEROL; PLANT EXTRACT; SARCOVAGENINE C; SARCOVAGINE D; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG PROTEIN BINDING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; HOLARRHENA; HOLARRHENA ANTIDYSENTERICA; IC 50; MOLECULAR MODEL; PLANT SEED; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; CHOLINESTERASE INHIBITORS; HOLARRHENA; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PLANT EXTRACTS; SEEDS; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

HOLARRHENA ANTIDYSENTERICA;

EID: 84862011671     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.04.017     Document Type: Article

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