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Volumn 287, Issue 24, 2012, Pages 20737-20747

Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SUBUNITS; LIFE SPAN; MOUSE CELLS; SOMATIC CELLS; TELOMERASE; TELOMERASE EXPRESSION; TUMOR SUPPRESSORS;

EID: 84862005661     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.319236     Document Type: Article
Times cited : (13)

References (54)
  • 2
    • 41349096243 scopus 로고    scopus 로고
    • Telomeres, stem cells, and hematology
    • Lansdorp, P. M. (2008) Telomeres, stem cells, and hematology. Blood 111, 1759-1766
    • (2008) Blood , vol.111 , pp. 1759-1766
    • Lansdorp, P.M.1
  • 3
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: The senescence connection
    • DOI 10.1038/nrc2393, PII NRC2393
    • Deng, Y., Chan, S. S., and Chang, S. (2008) Telomere dysfunction and tumour suppression: the senescence connection. Nat. Rev. Cancer 8, 450-458 (Pubitemid 351744962)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 4
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • Artandi, S. E., and DePinho, R. A. (2010) Telomeres and telomerase in cancer. Carcinogenesis 31, 9-18
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    DePinho, R.A.2
  • 5
    • 38449104105 scopus 로고    scopus 로고
    • Regulation of telomerase and telomeres: Human tumor viruses take control
    • DOI 10.1093/jnci/djm269
    • Bellon, M., and Nicot, C. (2008) Regulation of telomerase and telomeres: human tumor viruses take control. J. Natl. Cancer Inst. 100, 98-108 (Pubitemid 351480562)
    • (2008) Journal of the National Cancer Institute , vol.100 , Issue.2 , pp. 98-108
    • Bellon, M.1    Nicot, C.2
  • 6
    • 0033558281 scopus 로고    scopus 로고
    • Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
    • Horikawa, I., Cable, P. L., Afshari, C., and Barrett, J. C. (1999) Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res. 59, 826-830 (Pubitemid 29086735)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 826-830
    • Horikawa, I.1    Cable, P.L.2    Afshari, C.3    Barrett, J.C.4
  • 7
    • 0033082526 scopus 로고    scopus 로고
    • Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
    • Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., and Inoue, M. (1999) Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59, 551-557 (Pubitemid 29076049)
    • (1999) Cancer Research , vol.59 , Issue.3 , pp. 551-557
    • Takakura, M.1    Kyo, S.2    Kanaya, T.3    Hirano, H.4    Takeda, J.5    Yutsudo, M.6    Inoue, M.7
  • 8
    • 0032962953 scopus 로고    scopus 로고
    • The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
    • DOI 10.1093/hmg/8.1.137
    • Cong, Y. S., Wen, J., and Bacchetti, S. (1999) The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 8, 137-142 (Pubitemid 29039059)
    • (1999) Human Molecular Genetics , vol.8 , Issue.1 , pp. 137-142
    • Cong, Y.-S.1    Wen, J.2    Bacchetti, S.3
  • 9
    • 17644398434 scopus 로고    scopus 로고
    • Regulation of hTERT transcription: A target of cellular and viral mechanisms for immortalization and carcinogenesis
    • DOI 10.1007/s10616-004-5122-4
    • Horikawa, I., Michishita, E., and Barrett, J. C. (2004) Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis. Cytotechnology 45, 23-32 (Pubitemid 40568820)
    • (2004) Cytotechnology , vol.45 , Issue.1-2 , pp. 23-32
    • Horikawa, I.1    Michishita, E.2    Barrett, J.C.3
  • 10
    • 0034142386 scopus 로고    scopus 로고
    • Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)
    • Kyo, S., Takakura, M., Taira, T., Kanaya, T., Itoh, H., Yutsudo, M., Ariga, H., and Inoue, M. (2000) Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 28, 669-677 (Pubitemid 30068249)
    • (2000) Nucleic Acids Research , vol.28 , Issue.3 , pp. 669-677
    • Kyo, S.1    Takakura, M.2    Taira, T.3    Kanaya, T.4    Itoh, H.5    Yutsudo, M.6    Ariga, H.7    Inoue, M.8
  • 11
    • 4944240745 scopus 로고    scopus 로고
    • Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I-transformed cells
    • DOI 10.1182/blood-2003-12-4251
    • Sinha-Datta, U., Horikawa, I., Michishita, E., Datta, A., Sigler-Nicot, J. C., Brown, M., Kazanji, M., Barrett, J. C., and Nicot, C. (2004) Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I-transformed cells. Blood 104, 2523-2531 (Pubitemid 39331856)
    • (2004) Blood , vol.104 , Issue.8 , pp. 2523-2531
    • Sinha-Datta, U.1    Horikawa, I.2    Michishita, E.3    Datta, A.4    Sigler-Nicot, J.C.5    Brown, M.6    Kazanji, M.7    Barrett, J.C.8    Nicot, C.9
  • 12
    • 72149106462 scopus 로고    scopus 로고
    • Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells
    • Chebel, A., Rouault, J. P., Urbanowicz, I., Baseggio, L., Chien, W. W., Salles, G., and Ffrench, M. (2009) Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells. J. Biol. Chem. 284, 35725-35734
    • (2009) J. Biol. Chem. , vol.284 , pp. 35725-35734
    • Chebel, A.1    Rouault, J.P.2    Urbanowicz, I.3    Baseggio, L.4    Chien, W.W.5    Salles, G.6    Ffrench, M.7
  • 13
    • 0345549479 scopus 로고    scopus 로고
    • Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
    • DOI 10.1038/sj.onc.1206847
    • Goueli, B. S., and Janknecht, R. (2003) Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene 22, 8042-8047 (Pubitemid 37175868)
    • (2003) Oncogene , vol.22 , Issue.39 , pp. 8042-8047
    • Goueli, B.S.1    Janknecht, R.2
  • 14
    • 0033521960 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
    • DOI 10.1038/sj.onc.1202669
    • Greenberg, R. A., O'Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., and DePinho, R. A. (1999) Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 18, 1219-1226 (Pubitemid 29085995)
    • (1999) Oncogene , vol.18 , Issue.5 , pp. 1219-1226
    • Greenberg, R.A.1    O'Hagan, R.C.2    Deng, H.3    Xiao, Q.4    Hann, S.R.5    Adams, R.R.6    Lichtsteiner, S.7    Chin, L.8    Morin, G.B.9    DePinho, R.A.10
  • 15
    • 53449083111 scopus 로고    scopus 로고
    • Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells
    • Bellon, M., and Nicot, C. (2008) Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells. Blood 112, 2946-2955
    • (2008) Blood , vol.112 , pp. 2946-2955
    • Bellon, M.1    Nicot, C.2
  • 16
    • 38349150862 scopus 로고    scopus 로고
    • STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells
    • Nakatake, M., Kakiuchi, Y., Sasaki, N., Murakami-Murofushi, K., and Yamada, O. (2007) STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. Cell Cycle 6, 1496-1501
    • (2007) Cell Cycle , vol.6 , pp. 1496-1501
    • Nakatake, M.1    Kakiuchi, Y.2    Sasaki, N.3    Murakami-Murofushi, K.4    Yamada, O.5
  • 18
    • 35948943138 scopus 로고    scopus 로고
    • Mechanisms of action of TGF-β in cancer: Evidence for Smad3 as a repressor of the hTERT gene
    • DOI 10.1196/annals.1396.016, Healthy Aging and Longevity: Third International Conference
    • Li, H., and Liu, J. P. (2007) Mechanisms of action of TGF-β in cancer: evidence for Smad3 as a repressor of the hTERT gene. Ann. N.Y. Acad. Sci. 1114, 56-68 (Pubitemid 350070383)
    • (2007) Annals of the New York Academy of Sciences , vol.1114 , pp. 56-68
    • Li, H.1    Liu, J.-P.2
  • 20
    • 0035394055 scopus 로고    scopus 로고
    • E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    • Crowe, D. L., Nguyen, D. C., Tsang, K. J., and Kyo, S. (2001) E2F-1 re-presses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res. 29, 2789-2794 (Pubitemid 32685042)
    • (2001) Nucleic Acids Research , vol.29 , Issue.13 , pp. 2789-2794
    • Crowe, D.L.1    Nguyen, D.C.2    Tsang, K.J.3    Kyo, S.4
  • 21
    • 0034680840 scopus 로고    scopus 로고
    • Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells
    • Cong, Y. S., and Bacchetti, S. (2000) Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J. Biol. Chem. 275, 35665-35668
    • (2000) J. Biol. Chem. , vol.275 , pp. 35665-35668
    • Cong, Y.S.1    Bacchetti, S.2
  • 22
    • 0343673898 scopus 로고    scopus 로고
    • Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1
    • Günes, C., Lichtsteiner, S., Vasserot, A. P., and Englert, C. (2000) Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res. 60, 2116-2121 (Pubitemid 30225170)
    • (2000) Cancer Research , vol.60 , Issue.8 , pp. 2116-2121
    • Gunes, C.1    Lichtsteiner, S.2    Vasserot, A.P.3    Englert, C.4
  • 23
    • 0034624675 scopus 로고    scopus 로고
    • Identification of Mad as a repressor of the human telomerase (hTERT) gene
    • Oh, S., Song, Y. H., Yim, J., and Kim, T. K. (2000) Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene 19, 1485-1490 (Pubitemid 30171181)
    • (2000) Oncogene , vol.19 , Issue.11 , pp. 1485-1490
    • Oh, S.1    Song, Y.-H.2    Yim, J.3    Kim, T.K.4
  • 24
    • 0033601234 scopus 로고    scopus 로고
    • The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene
    • Oh, S., Song, Y., Yim, J., and Kim, T. K. (1999) The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. J. Biol. Chem. 274, 37473-37478
    • (1999) J. Biol. Chem. , vol.274 , pp. 37473-37478
    • Oh, S.1    Song, Y.2    Yim, J.3    Kim, T.K.4
  • 25
    • 0036677419 scopus 로고    scopus 로고
    • Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: Evidence for an endogenous mechanism of transcriptional repression
    • Horikawa, I., Cable, P. L., Mazur, S. J., Appella, E., Afshari, C. A., and Barrett, J. C. (2002) Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. Mol. Biol. Cell 13, 2585-2597
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2585-2597
    • Horikawa, I.1    Cable, P.L.2    Mazur, S.J.3    Appella, E.4    Afshari, C.A.5    Barrett, J.C.6
  • 26
    • 33748741642 scopus 로고    scopus 로고
    • Transforming growth factor β suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene
    • DOI 10.1074/jbc.M602381200
    • Li, H., Xu, D., Li, J., Berndt, M. C., and Liu, J. P. (2006) Transforming growth factor β suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. J. Biol. Chem. 281, 25588-25600 (Pubitemid 44401948)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25588-25600
    • Li, H.1    Xu, D.2    Li, J.3    Berndt, M.C.4    Liu, J.-P.5
  • 27
    • 77957988663 scopus 로고    scopus 로고
    • Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways
    • Sitaram, R. T., Degerman, S., Ljungberg, B., Andersson, E., Oji, Y., Sugiyama, H., Roos, G., and Li, A. (2010) Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways. Br. J. Cancer 103, 1255-1262
    • (2010) Br. J. Cancer , vol.103 , pp. 1255-1262
    • Sitaram, R.T.1    Degerman, S.2    Ljungberg, B.3    Andersson, E.4    Oji, Y.5    Sugiyama, H.6    Roos, G.7    Li, A.8
  • 28
    • 0032792828 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells
    • Kusumoto, M., Ogawa, T., Mizumoto, K., Ueno, H., Niiyama, H., Sato, N., Nakamura, M., and Tanaka, M. (1999) Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells. Clin. Cancer Res. 5, 2140-2147 (Pubitemid 29399270)
    • (1999) Clinical Cancer Research , vol.5 , Issue.8 , pp. 2140-2147
    • Kusumoto, M.1    Ogawa, T.2    Mizumoto, K.3    Ueno, H.4    Niiyama, H.5    Sato, N.6    Nakamura, M.7    Tanaka, M.8
  • 29
    • 33748275681 scopus 로고    scopus 로고
    • The p53 tumor suppressor participates in multiple cell cycle checkpoints
    • DOI 10.1002/jcp.20689
    • Giono, L. E., and Manfredi, J. J. (2006) The p53 tumor suppressor participates in multiple cell cycle checkpoints. J. Cell. Physiol. 209, 13-20 (Pubitemid 44318664)
    • (2006) Journal of Cellular Physiology , vol.209 , Issue.1 , pp. 13-20
    • Giono, L.E.1    Manfredi, J.J.2
  • 30
    • 3543110350 scopus 로고    scopus 로고
    • p63 and p73: Roles in development and tumor formation
    • Moll, U. M., and Slade, N. (2004) p63 and p73: roles in development and tumor formation. Mol. Cancer Res. 2, 371-386 (Pubitemid 39031071)
    • (2004) Molecular Cancer Research , vol.2 , Issue.7 , pp. 371-386
    • Moll, U.M.1    Slade, N.2
  • 31
    • 85027935101 scopus 로고    scopus 로고
    • The association between non-Hodgkin lymphoma and methylation of p73
    • Pei, J. H., Luo, S. Q., Zhong, Y., Chen, J. H., Xiao, H. W., and Hu, W. X. (2011) The association between non-Hodgkin lymphoma and methylation of p73. Tumour Biol. 32, 1133-1138
    • (2011) Tumour Biol. , vol.32 , pp. 1133-1138
    • Pei, J.H.1    Luo, S.Q.2    Zhong, Y.3    Chen, J.H.4    Xiao, H.W.5    Hu, W.X.6
  • 33
    • 0033565514 scopus 로고    scopus 로고
    • Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation
    • Corn, P. G., Kuerbitz, S. J., van Noesel, M. M., Esteller, M., Compitello, N., Baylin, S. B., and Herman, J. G. (1999) Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res. 59, 3352-3356 (Pubitemid 29334490)
    • (1999) Cancer Research , vol.59 , Issue.14 , pp. 3352-3356
    • Corn, P.G.1    Kuerbitz, S.J.2    Van Noesel, M.M.3    Esteller, M.4    Compitello, N.5    Baylin, S.B.6    Herman, J.G.7
  • 34
    • 22044447523 scopus 로고    scopus 로고
    • The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes
    • DOI 10.1593/neo.04766
    • Glasspool, R. M., Burns, S., Hoare, S. F., Svensson, C., and Keith, W. N. (2005) The hTERT and hTERC telomerase gene promoters are activated by the second exon of the adenoviral protein, E1A, identifying the transcriptional corepressor CtBP as a potential repressor of both genes. Neoplasia 7, 614-622 (Pubitemid 40967762)
    • (2005) Neoplasia , vol.7 , Issue.6 , pp. 614-622
    • Glasspool, R.M.1    Burns, S.2    Hoare, S.F.3    Svensson, C.4    Keith, W.N.5
  • 35
    • 0037077721 scopus 로고    scopus 로고
    • Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73
    • Dietz, S., Rother, K., Bamberger, C., Schmale, H., Mössner, J., and Engeland, K. (2002) Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73. FEBS Lett. 525, 93-99
    • (2002) FEBS Lett. , vol.525 , pp. 93-99
    • Dietz, S.1    Rother, K.2    Bamberger, C.3    Schmale, H.4    Mössner, J.5    Engeland, K.6
  • 36
    • 44349086038 scopus 로고    scopus 로고
    • Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site
    • DOI 10.1093/nar/gkn132
    • Kirschner, R. D., Sänger, K., Müller, G. A., and Engeland, K. (2008) Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. Nucleic Acids Res. 36, 2969-2980 (Pubitemid 351737189)
    • (2008) Nucleic Acids Research , vol.36 , Issue.9 , pp. 2969-2980
    • Kirschner, R.D.1    Sanger, K.2    Muller, G.A.3    Engeland, K.4
  • 37
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53-related protein that can induce apoptosis
    • DOI 10.1038/38298
    • Jost, C. A., Marin, M. C., and Kaelin, W. G., Jr. (1997) p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 389, 191-194 (Pubitemid 27400602)
    • (1997) Nature , vol.389 , Issue.6647 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin Jr., W.G.3
  • 39
    • 41149094081 scopus 로고    scopus 로고
    • A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response
    • DOI 10.1093/nar/gkm1046
    • Benatti, P., Basile, V., Merico, D., Fantoni, L. I., Tagliafico, E., and Imbriano, C. (2008) A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response. Nucleic Acids Res. 36, 1415-1428 (Pubitemid 351426096)
    • (2008) Nucleic Acids Research , vol.36 , Issue.5 , pp. 1415-1428
    • Benatti, P.1    Basile, V.2    Merico, D.3    Fantoni, L.I.4    Tagliafico, E.5    Imbriano, C.6
  • 40
    • 0038607475 scopus 로고    scopus 로고
    • Role of the intronic enhancer in tumor necrosis factor-mediated induction of manganous superoxide dismutase
    • DOI 10.1074/jbc.M303431200
    • Guo, Z., Boekhoudt, G. H., and Boss, J. M. (2003) Role of the intronic enhancer in tumor necrosis factor-mediated induction of manganous superoxide dismutase. J. Biol. Chem. 278, 23570-23578 (Pubitemid 36830177)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.26 , pp. 23570-23578
    • Guo, Z.1    Boekhoudt, G.H.2    Boss, J.M.3
  • 41
    • 28844475856 scopus 로고    scopus 로고
    • C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter
    • DOI 10.1074/jbc.C500193200
    • Racek, T., Mise, N., Li, Z., Stoll, A., and Pützer, B. M. (2005) C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter. J. Biol. Chem. 280, 40402-40405 (Pubitemid 41780526)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.49 , pp. 40402-40405
    • Racek, T.1    Mise, N.2    Li, Z.3    Stoll, A.4    Putzer, B.M.5
  • 43
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. (1998) The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 44
    • 33746589840 scopus 로고    scopus 로고
    • Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence
    • DOI 10.1182/blood-2006-01-0067
    • Datta, A., Bellon, M., Sinha-Datta, U., Bazarbachi, A., Lepelletier, Y., Canioni, D., Waldmann, T. A., Hermine, O., and Nicot, C. (2006) Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood 108, 1021-1029 (Pubitemid 44154640)
    • (2006) Blood , vol.108 , Issue.3 , pp. 1021-1029
    • Datta, A.1    Bellon, M.2    Sinha-Datta, U.3    Bazarbachi, A.4    Lepelletier, Y.5    Canioni, D.6    Waldmann, T.A.7    Hermine, O.8    Nicot, C.9
  • 45
    • 0041857759 scopus 로고    scopus 로고
    • p21/CDKN1A mediates negative regulation of transcription by p53
    • DOI 10.1074/jbc.M212517200
    • Löhr, K., Möritz, C., Contente, A., and Dobbelstein, M. (2003) p21/CDKN1A mediates negative regulation of transcription by p53. J. Biol. Chem. 278, 32507-32516 (Pubitemid 37055688)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.35 , pp. 32507-32516
    • Lohr, K.1    Moritz, C.2    Contente, A.3    Dobbelstein, M.4
  • 47
    • 32544431946 scopus 로고    scopus 로고
    • Regulation of telomerase activity by the p53 family member p73
    • DOI 10.1038/sj.onc.1209125, PII 1209125
    • Beitzinger, M., Oswald, C., Beinoraviciute-Kellner, R., and Stiewe, T. (2006) Regulation of telomerase activity by the p53 family member p73. Oncogene 25, 813-826 (Pubitemid 43237700)
    • (2006) Oncogene , vol.25 , Issue.6 , pp. 813-826
    • Beitzinger, M.1    Oswald, C.2    Beinoraviciute-Kellner, R.3    Stiewe, T.4
  • 48
    • 0034048726 scopus 로고    scopus 로고
    • Adenoviral expression of p53 represses telomerase activity through down- regulation of human telomerase reverse transcriptase transcription
    • Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., and Inoue, M. (2000) Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin. Cancer Res. 6, 1239-1247 (Pubitemid 30226203)
    • (2000) Clinical Cancer Research , vol.6 , Issue.4 , pp. 1239-1247
    • Kanaya, T.1    Kyo, S.2    Hamada, K.3    Takakura, M.4    Kitagawa, Y.5    Harada, H.6    Inoue, M.7
  • 49
    • 23844476499 scopus 로고    scopus 로고
    • 1 cell cycle arrest
    • DOI 10.1128/MCB.25.17.7423-7431.2005
    • Ho, J. S., Ma, W., Mao, D. Y., and Benchimol, S. (2005) p53-dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol. Cell. Biol. 25, 7423-7431 (Pubitemid 41170106)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.17 , pp. 7423-7431
    • Ho, J.S.L.1    Ma, W.2    Mao, D.Y.L.3    Benchimol, S.4
  • 50
    • 0026767232 scopus 로고
    • Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line
    • Moberg, K. H., Tyndall, W. A., and Hall, D. J. (1992) Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line. J. Cell. Biochem. 49, 208-215
    • (1992) J. Cell. Biochem. , vol.49 , pp. 208-215
    • Moberg, K.H.1    Tyndall, W.A.2    Hall, D.J.3
  • 51
    • 0037131397 scopus 로고    scopus 로고
    • p73 independent of c-Myc represses transcription of platelet-derived growth factor β-receptor through interaction with NF-Y
    • DOI 10.1074/jbc.M204483200
    • Hackzell, A., Uramoto, H., Izumi, H., Kohno, K., and Funa, K. (2002) p73 independent of c-Myc represses transcription of platelet-derived growth factor β-receptor through interaction with NF-Y. J. Biol. Chem. 277, 39769-39776 (Pubitemid 35190960)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39769-39776
    • Hackzell, A.1    Uramoto, H.2    Izumi, H.3    Kohno, K.4    Funa, K.5
  • 53
    • 0030065440 scopus 로고    scopus 로고
    • Immortalization of human mammary epithelial cells transfected with mutant p53 (273his)
    • Gollahon, L. S., and Shay, J. W. (1996) Immortalization of human mammary epithelial cells transfected with mutant p53 (273his). Oncogene 12, 715-725
    • (1996) Oncogene , vol.12 , pp. 715-725
    • Gollahon, L.S.1    Shay, J.W.2
  • 54
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1


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