Mendelian randomisation study of childhood BMI and early menarche

Journal of Obesity

Volumn 2011, Issue , 2011, Pages

  Mumby, Hannah S ^a   Elks, Cathy E ^a   Li, Shengxu ^a   Sharp, Stephen J ^a   Khaw, Kay Tee ^b   Luben, Robert N ^b   Wareham, Nicholas J ^a   Loos, Ruth J F ^a   Ong, Ken K ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862002169     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2011/180729     Document Type: Article

References (38)

1. Lakshman R., Forouhi N. G., Sharp S. J., Luben R., Bingham S. A., Khaw K. T., Wareham N. J., Ong K. K., Early age at menarche associated with cardiovascular disease and mortality. Journal of Clinical Endocrinology and Metabolism 2009 94 12 4953 4960 2-s2.0-73249115154 10.1210/jc.2009-1789
2. Hartge P., Genetics of reproductive lifespan. Nature Genetics 2009 41 6 637 638 2-s2.0-66649131031 10.1038/ng0609-637
3. Golub M. S., Collman G. W., Foster P. M. D., Kimmel C. A., Rajpert-De-Meyts E., Reiter E. O., Sharpe R. M., Skakkebaek N. E., Toppari J., Public health implications of altered puberty timing. Pediatrics 2008 121 3 S218 S230 2-s2.0-39849100603 10.1542/peds.2007-1813G
4. Kaplowitz P. B., Link between body fat and the timing of puberty. Pediatrics 2008 121 supplement 3 S208 S217 2-s2.0-39849092163 10.1542/peds.2007-1813F
5. Ahmed M. L., Ong K. K., Dunger D. B., Childhood obesity and the timing of puberty. Trends in Endocrinology and Metabolism 2009 20 5 237 242 2-s2.0-67649224071 10.1016/j.tem.2009.02.004
6. Euling S. Y., Herman-Giddens M. E., Lee P. A., Selevan S. G., Juul A., Sorensen T. I. A., Dunkel L., Himes J. H., Teilmann G., Swan S. H., Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 2008 121 supplement 3 S172 S191 2-s2.0-39849108680 10.1542/peds.2007-1813D
7. Bundred P., Kitchiner D., Buchan I., Prevalence of overweight and obese children between 1989 and 1998: population based series of cross sectional studies. BMJ 2001 322 7282 326 328 2-s2.0-0035835388
8. Jacobson-Dickman E., Lee M. M., The influence of endocrine disruptors on pubertal timing. Current Opinion in Endocrinology, Diabetes and Obesity 2009 16 1 25 30 2-s2.0-58849159236 10.1097/MED.0b013e328320d560
9. Jasik C. B., Lustig R. H., Adolescent obesity and puberty: the perfect storm Annals of the New York Academy of Sciences 2008 1135 265 279 2-s2.0-45549084976 10.1196/annals.1429.009
10. Greenland S., An introduction to instrumental variables for epidemiologists. International Journal of Epidemiology 2000 29 6 1102 2-s2.0-0034529563
11. Lawlor D. A., Harbord R. M., Sterne J. A. C., Timpson N., Smith G. D., Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Statistics in Medicine 2008 27 8 1133 1163 2-s2.0-40849083720 10.1002/sim.3034
12. Kathiresan S., A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. The New England Journal of Medicine 2008 358 21 2299 2300 2-s2.0-44249122796 10.1056/NEJMc0707445
13. Thompson A., di Angelantonio E., Sarwar N., Erqou S., Saleheen D., Dullaart R. P. F., Keavney B., Ye Z., Danesh J., Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. Journal of the American Medical Association 2008 299 23 2777 2788 2-s2.0-45349105911 10.1001/jama.299.23.2777
14. Zacho J., Tybjærg-Hansen A., Jensen J. S., Grande P., Sillesen H., Nordestgaard B. G., Genetically elevated C-reactive protein and ischemic vascular disease. The New England Journal of Medicine 2008 359 18 1897 1908 2-s2.0-55249087635 10.1056/NEJMoa0707402
15. Timpson N. J., Harbord R., Smith G. D., Zacho J., Tybjærg-Hansen A., Nordestgaard B. G., Does greater adiposity increase blood pressure and hypertension risk?: mendelian randomization using the FTO/MC4R genotype. Hypertension 2009 54 1 84 90 2-s2.0-67649855154 10.1161/HYPERTENSIONAHA.109. 130005
16. Kivimäki M., Smith G. D., Timpson N. J., Lawlor D. A., Batty G. D., Kähönen M., Juonala M., Rönnemaa T., Viikari J. S. A., Lehtimäki T., Raitakari O. T., Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using mendelian randomization in the cardiovascular risk in young finns study. European Heart Journal 2008 29 20 2552 2560 2-s2.0-54149096173 10.1093/eurheartj/ehn252
17. Frayling T. M., Timpson N. J., Weedon M. N., Zeggini E., Freathy R. M., Lindgren C. M., Perry J. R. B., Elliott K. S., Lango H., Rayner N. W., Shields B., Harries L. W., Barrett J. C., Ellard S., Groves C. J., Knight B., Patch A. M., Ness A. R., Ebrahim S., Lawlor D. A., Ring S. M., Ben-Shlomo Y., Jarvelin M. R., Sovio U., Bennett A. J., Melzer D., Ferrucci L., Loos R. J. F., Barroso I., Wareham N. J., Karpe F., Owen K. R., Cardon L. R., Walker M., Hitman G. A., Palmer C. N. A., Doney A. S. F., Morris A. D., Smith G. D., Hattersley A. T., McCarthy M. I., A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007 316 5826 889 894 2-s2.0-34248594090 10.1126/science.1141634
18. Loos R. J. F., Lindgren C. M., Li S., Wheeler E., Zhao J. H., Prokopenko I., Inouye M., Freathy R. M., Attwood A. P., Beckmann J. S., Berndt S. I., Jacobs K. B., Chanock S. J., Hayes R. B., Bergmann S., Bennett A. J., Bingham S. A., Bochud M., Brown M., Cauchi S., Connell J. M., Cooper C., Smith G. D., Day I., Dina C., De S., Dermitzakis E. T., Doney A. S. F., Elliott K. S., Elliott P., Evans D. M., Sadaf Farooqi I., Froguel P., Ghori J., Groves C. J., Gwilliam R., Hadley D., Hall A. S., Hattersley A. T., Hebebrand J., Heid I. M., Lamina C., Gieger C., Illig T., Meitinger T., Wichmann H. E., Herrera B., Hinney A., Hunt S. E., Jarvelin M. R., Johnson T., Jolley J. D. M., Karpe F., Keniry A., Khaw K. T., Luben R. N., Mangino M., Marchini J., McArdle W. L., McGinnis R., Meyre D., Munroe P. B., Morris A. D., Ness A. R., Neville M. J., Nica A. C., Ong K. K., O'Rahilly S., Owen K. R., Palmer C. N. A., Papadakis K., Potter S., Pouta A., Qi LU., Kraft P., Hankinson S. E., Hunter D. J., Hu F. B., Randall J. C., Rayner N. W., Ring S. M., Sandhu M. S., Scherag A., Sims M. A., Song K., Soranzo N., Speliotes E. K., Lyon H. N., Voight B. F., Ridderstrale M., Groop L., Syddall H. E., Teichmann S. A., Timpson N. J., Tobias J. H., Uda M., Scheet P., Sanna S., Abecasis G. R., Albai G., Nagaraja R., Schlessinger D., Ganz Vogel C. I., Wallace C., Waterworth D. M., Weedon M. N., Willer C. J., Jackson A. U., Tuomilehto J., Collins F. S., Boehnke M., Mohlke K. L., Wraight V. L., Yuan X., Zeggini E., Hirschhorn J. N., Strachan D. P., Ouwehand W. H., Caulfield M. J., Samani N. J., Frayling T. M., Vollenweider P., Waeber G., Mooser V., Deloukas P., McCarthy M. I., Wareham N. J., Barroso I., Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 2008 40 6 768 775 2-s2.0-44349142294 10.1038/ng.140
19. Willer C. J., Speliotes E. K., Loos R. J. F., Li S., Lindgren C. M., Heid I. M., Berndt S. I., Elliott A. L., Jackson A. U., Lamina C., Lettre G., Lim N., Lyon H. N., McCarroll S. A., Papadakis K., Qi LU., Randall J. C., Roccasecca R. M., Sanna S., Scheet P., Weedon M. N., Wheeler E., Zhao J. H., Jacobs L. C., Prokopenko I., Soranzo N., Tanaka T., Timpson N. J., Almgren P., Bennett A., Bergman R. N., Bingham S. A., Bonnycastle L. L., Brown M., Burtt N. P., Chines P., Coin L., Collins F. S., Connell J. M., Cooper C., Smith G. D., Dennison E. M., Deodhar P., Elliott P., Erdos M. R., Estrada K., Evans D. M., Gianniny L., Gieger C., Gillson C. J., Guiducci C., Hackett R., Hadley D., Hall A. S., Havulinna A. S., Hebebrand J., Hofman A., Isomaa BO., Jacobs K. B., Johnson T., Jousilahti P., Jovanovic Z., Khaw K. T., Kraft P., Kuokkanen M., Kuusisto J., Laitinen J., Lakatta E. G., Luan J., Luben R. N., Mangino M., McArdle W. L., Meitinger T., Mulas A., Munroe P. B., Narisu N., Ness A. R., Northstone K., O'Rahilly S., Purmann C., Rees M. G., Ridderstråle M., Ring S. M., Rivadeneira F., Ruokonen A., Sandhu M. S., Saramies J., Scott L. J., Scuteri A., Silander K., Sims M. A., Song K., Stephens J., Stevens S., Stringham H. M., Tung Y. C. L., Valle T. T., Van Duijn C. M., Vimaleswaran K. S., Vollenweider P., Waeber G., Wallace C., Watanabe R. M., Waterworth D. M., Watkins N., Witteman J. C. M., Zeggini E., Zhai G., Zillikens M. C., Altshuler D., Caulfield M. J., Chanock S. J., Farooqi I. S., Ferrucci L., Guralnik J. M., Hattersley A. T., Hu F. B., Jarvelin M. R., Laakso M., Mooser V., Ong K. K., Ouwehand W. H., Salomaa V., Samani N. J., Spector T. D., Tuomi T., Tuomilehto J., Uda M., Uitterlinden A. G., Wareham N. J., Deloukas P., Frayling T. M., Groop L. C., Hayes R. B., Hunter D. J., Mohlke K. L., Peltonen L., Schlessinger D., Strachan D. P., Wichmann H. E., McCarthy M. I., Boehnke M., Barroso I., Abecasis G. R., Hirschhorn J. N., Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2009 41 1 25 34 2-s2.0-58149163142 10.1038/ng.287
20. Thorleifsson G., Walters G. B., Gudbjartsson D. F., Steinthorsdottir V., Sulem P., Helgadottir A., Styrkarsdottir U., Gretarsdottir S., Thorlacius S., Jonsdottir I., Jonsdottir T., Olafsdottir E. J., Olafsdottir G. H., Jonsson T., Jonsson F., Borch-Johnsen K., Hansen T., Andersen G., Jorgensen T., Lauritzen T., Aben K. K., Verbeek A. L. M., Roeleveld N., Kampman E., Yanek L. R., Becker L. C., Tryggvadottir L., Rafnar T., Becker D. M., Gulcher J., Kiemeney L. A., Pedersen O., Kong A., Thorsteinsdottir U., Stefansson K., Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 2009 41 1 18 24 2-s2.0-58149163141 10.1038/ng.274
21. Sulem P., Gudbjartsson D. F., Rafnar T., Holm H., Olafsdottir E. J., Olafsdottir G. H., Jonsson T., Alexandersen P., Feenstra B., Boyd H. A., Aben K. K., Verbeek A. L. M., Roeleveld N., Jonasdottir A., Styrkarsdottir U., Steinthorsdottir V., Karason A., Stacey S. N., Gudmundsson J., Jakobsdottir M., Thorleifsson G., Hardarson G., Gulcher J., Kong A., Kiemeney L. A., Melbye M., Christiansen C., Tryggvadottir L., Thorsteinsdottir U., Stefansson K., Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nature Genetics 2009 41 6 734 738 2-s2.0-66649116283 10.1038/ng.383
22. Perry J. R. B., Stolk L., Franceschini N., Lunetta K. L., Zhai G., McArdle P. F., Smith A. V., Aspelund T., Bandinelli S., Boerwinkle E., Cherkas L., Eiriksdottir G., Estrada K., Ferrucci L., Folsom A. R., Garcia M., Gudnason V., Hofman A., Karasik D., Kiel D. P., Launer L. J., Van Meurs J., Nalls M. A., Rivadeneira F., Shuldiner A. R., Singleton A., Soranzo N., Tanaka T., Visser J. A., Weedon M. N., Wilson S. G., Zhuang V., Streeten E. A., Harris T. B., Murray A., Spector T. D., Demerath E. W., Uitterlinden A. G., Murabito J. M., Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics 2009 41 6 648 650 2-s2.0-66649123583 10.1038/ng.386
23. Day N., Oakes S., Luben R., EPIC-Norfolk: study design and characteristics of the cohort. European prospective investigation of cancer. British Journal of Cancer 1999 80 supplement 1 95 103
24. Li S., Zhao J. H., Luan J., Luben R. N., Rodwell S. A., Khaw K. T., Ong K. K., Wareham N. J., Loos R. J. F., Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. American Journal of Clinical Nutrition 2010 91 1 184 190 2-s2.0-74049138315 10.3945/ajcn.2009.28403
25. Frontini M. G., Srinivasan S. R., Berenson G. S., Longitudinal changes in risk variables underlying metabolic syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa heart study. International Journal of Obesity 2003 27 1398 1404
26. Remsberg K. E., Demerath E. W., Schubert C. M., Chumlea WM. C., Sun S. S., Siervogel R. M., Early menarche and the development of cardiovascular disease risk factors in adolescent girls: the fels longitudinal study. Journal of Clinical Endocrinology and Metabolism 2005 90 5 2718 2724 2-s2.0-18844448128 10.1210/jc.2004-1991
27. den Hoed M., Ekelund U., Brage S., Genetic susceptibility to obesity and related traits in childhood and adolescence; influence of loci identified by genome-wide association studies. Diabetes 2010 59 11 2980 2988 10.2337/db10-0370
28. Elks C. E., Loos R. J. F., Sharp S. J., Langenberg C., Ring S. M., Timpson N. J., Ness A. R., Smith G. D., Dunger D. B., Wareham N. J., Ong K. K., Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Medicine 2010 7 5 e1000284 2-s2.0-77953270825 10.1371/journal.pmed.1000284
29. Elks C. E., Perry J. R., Sulem P., Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics 2010 42 12 1077 1085
30. Kovalchik S., Validity of adult lifetime self-reported body weight. Public Health Nutrition 2009 12 8 1072 1077
31. Freedman D. S., Khan L. K., Serdula M. K., Dietz W. H., Srinivasan S. R., Berenson G. S., The relation of menarcheal age to obesity in childhood and adulthood: the Bogalusa heart study. BMC Pediatrics 2003 3 1, article 3 2-s2.0-0142212402
32. Chavarro J. E., Peterson K. E., Sobol A. M., Wiecha J. L., Gortmaker S. L., Effects of a school-based obesity-prevention intervention on menarche (United States). Cancer Causes and Control 2005 16 10 1245 1252 2-s2.0-33644877536 10.1007/s10552-005-0404-5
33. Ong K. K., Emmett P., Northstone K., Golding J., Rogers I., Ness A. R., Wells J. C., Dunger D. B., Infancy weight gain predicts childhood body fat and age at menarche in girls. Journal of Clinical Endocrinology and Metabolism 2009 94 5 1527 1532 2-s2.0-66149083705 10.1210/jc.2008-2489
34. Buyken A. E., Karaolis-Danckert N., Remer T., Association of prepubertal body composition in healthy girls and boys with the timing of early and late pubertal markers. American Journal of Clinical Nutrition 2009 89 1 221 230 2-s2.0-58149381823 10.3945/ajcn.2008.26733
35. Must A., Naumova E. N., Phillips S. M., Blum M., Dawson-Hughes B., Rand W. M., Childhood overweight and maturational timing in the development of adult overweight and fatness: the newton girls study and its follow-up. Pediatrics 2005 116 3 620 627 2-s2.0-33644612183 10.1542/peds.2004-1604
36. Lee J. M., Appugliese D., Kaciroti N., Corwyn R. F., Bradley R. H., Lumeng J. C., Weight status in young girls and the onset of puberty. Pediatrics 2007 119 3 e624 e630 2-s2.0-33947156663 10.1542/peds.2006-2188
37. Ong K. K., Elks C. E., Wills A. K., Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life-course. Journal of Clinical Endocrinology & Metabolism 2011 96 E125 E129
38. Ong K. K., Ahmed M. L., Dunger D. B., Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): the European trend. Molecular and Cellular Endocrinology 2006 254-255 8 12 2-s2.0-33745909453 10.1016/j.mce.2006.04.018