Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20509-20521

  Singh, Aditya K ^a   McMillan, Jacob ^b   Bukiya, Anna N ^a   Burton, Brittany ^b   Parrill, Abby L ^b   Dopico, Alex M ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b University of Memphis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; BIOLOGICAL PROCESS; BK-CHANNEL; CHANNEL INTERACTIONS; CHANNEL PROTEINS; CONSENSUS MOTIF; CRAC MOTIF; CYTOSOLIC; ENDOTHELIAL FUNCTION; HYDROPHOBIC INTERACTIONS; ION CHANNEL; ION TRANSPORTS; MEMBRANE CHOLESTEROL; MEMBRANE-ASSOCIATED PROTEINS; PROTEIN SURFACE; SMOOTH MUSCLES; STRUCTURAL BASIS;

AMINO ACIDS; CELL MEMBRANES; CYTOLOGY; HYDROGEN BONDS; PROTEINS;

CHOLESTEROL;

CALCIUM CHANNEL; CHOLESTEROL; CHOLESTEROL RECOGNITION INTERACTION AMINO ACID CONSENSUS PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOSOL; ENZYME REGULATION; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; RAT; SENSITIVITY ANALYSIS;

AMINO ACID MOTIFS; CELL MEMBRANE; CHOLESTEROL; HUMANS; HYDROGEN BONDING; ION TRANSPORT; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY;

EID: 84862001785     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.356261     Document Type: Article

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