Deletion of thyrotropin receptor residue Asp403 in a hyperfunctioning thyroid nodule provides insight into the role of the ectodomain in ligand-induced receptor activation

Journal of Endocrinological Investigation

Volumn 35, Issue 1, 2012, Pages 49-53

  Nishihara, E ^a   Chen, C R ^b   Mizutori Sasai, Y ^a   Ito, M ^a   Kubota, S ^a   Amino, N ^a   Miyauchi, A ^a   Rapoport, B ^b  

^a KUMA HOSPITAL   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenylyl cyclase activation; Autonomously functioning thyroid nodule; Ectodomain; Somatic mutation; Thyrotropin receptor

Indexed keywords

ASPARTIC ACID; IODINE 131; THYROTROPIN; THYROTROPIN RECEPTOR;

ADULT; ANIMAL TISSUE; ARTICLE; CASE REPORT; CONTROLLED STUDY; DNA SEQUENCE; FLOW CYTOMETRY; GENE DELETION; HETEROZYGOTE; HUMAN; IN VITRO STUDY; LIGAND BINDING; MALE; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR GENE; SOMATIC MUTATION; SUBTOTAL THYROIDECTOMY; THYROID FUNCTION; THYROID NODULE; THYROTOXICOSIS;

ADENOMA; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, THYROTROPIN; SEQUENCE DELETION; THYROID FUNCTION TESTS; THYROID NEOPLASMS; THYROID NODULE; THYROTROPIN;

EID: 84861997613     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7738     Document Type: Article

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