2,5-Dihydroxyacetophenone isolated from rehmanniae radix preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages

Journal of Medicinal Food

Volumn 15, Issue 6, 2012, Pages 505-510

  Han, Yunkyung ^a   Jung, Hyo Won ^a   Lee, Joo Young ^b   Kim, Ju Sun ^b   Kang, Sam Sik ^b   Kim, Yeong Shik ^b   Park, Yong Ki ^a  

^a Dongguk University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

2,5 dihydroxyacetophenone; inflammation; RAW264.7 macrophages; Rehmanniae Radix Preparata

Indexed keywords

2,5 DIHYDROXYACETOPHENONE; ACETOPHENONE DERIVATIVE; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; REHMANNIA GLUTINOSA EXTRACT; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELL STIMULATION; CHINESE HERB; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION; REHMANNIA GLUTINOSA;

ACETOPHENONES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; REHMANNIA; RNA, MESSENGER; SIGNAL TRANSDUCTION;

REHMANNIA GLUTINOSA;

EID: 84861997600     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.1940     Document Type: Article

References (20)

1. Li C, Wang MH: Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS stimulated Raw 264.7 cells. Nutr Res Pract 2011;5:101-106.
2. Wang CC, Choy CS, Liu YH, Cheah KP, Li JS, Wang JTJ, Yu WY, Lin CW, Cheng HW, Hu CM: Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages. J Sci Food Agric 2010;91:218-225.
3. Fan J, Liu Z, Luo T, Xi Z, Song J, Liu B: Modified si-miao-san extract inhibits the release of inflammatory mediators from lipopolysaccharide- stimulated mouse macrophages. J Ethnopharmacol 2010;129:5-9.
4. Jung HW, Chung YS, Kim YS, Park YK: Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-jB in LPS-stimulated BV-2 microglial cells. Exp Mol Med 2007;39:715-721.
5. Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM: Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW264.7 cells. J Ethnopharmacol 2009;123:97-105.
6. Jedinak A, Dudhgaonkar S, Wu QL, Simon J, Sliva D: Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling. Nutr J 2011;10:52. doi: 10.1186/1475-2891-10-52.
7. Kwon OK, Ahn KS, Park JW, Jang HY, Joung H, Lee HK, Oh SR: Ethanol extract of elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells. Inflammation 2011;35:535-544.
8. Zha LY, Mao LM, Lu XC, Deng H, Ye JF, Chu XW, Sun SX, Luo HJ: Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW264.7 cells by attenuation of NF-κB mediated nitric oxide synthase expression. Bioorg Med Chem Lett 2011;21:2415-2418.
9. Jung HW, Yoon CH, Kim YH, Boo YC, Park KM, Park YK: Wen-pi-tang-hab-wu- ling-san extract inhibits the release of inflammatory mediators from LPS-stimulated mouse macrophages. J Ethnopharmacol 2007;114:439-445. (Pubitemid 350026228)
10. Chae HJ, Kim HR, Kim DS, Woo ER, Cho YG, Chae SW: Saengji-hwang has a protective effect on adriamycin-induced cytotoxicity in cardiac muscle cells. Life Sci 2005;76:2027-2042.
11. Lau TW, Lam FFY, Lau KM, Chan YW, Lee LM, Sahota DS, Ho YY, Fung KP, Leung PC, Lau CBS: Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J Ethnopharmacol 2009;123:155-162.
12. Yokozawa T, Kim HY, Yamabe N: Amelioration of diabetic nephropathy by dried Rehmanniae Radix (di huang) extract. Am J Chin Med 2004;32:829-839. (Pubitemid 40012452)
13. Lee JY, Lee EJ, Kim JS, Lee JH, Kang SS: Phytochemical studies on Rehmanniae Radix Preparata. Korean J Pharmacogn 2011;42:117-126.
14. Zhang RX, Li MX, Jia ZP: Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117:199-214.
15. Choi JH, Park YN, Li Y, Jin MH, Lee J, Lee Y, Son JK, Chang HW, Lee E: Flowers of Inula japonica attenuate inflammatory responses. Immune Netw 2010;10:145-152.
16. Kim KM, Kwon YG, Chung HT, Yun YG, Pae HO, Han JA, Ha KS, Kim TW, Kim YM: Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppression NF-κB activation. Toxicol Appl Pharmacol 2003;190:1-8.
17. Park CM, Jin KS, Lee YW, Song YS: Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW264.7 cells. Eur J Pharmacol 2011;660:454-459.
18. Gao Y, Xu P, Chen L, Li Y: Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side effect. Int J Pharm 2010;387:263-271.
19. Shapira L, Soskolne WA, Houri Y, Barak V, Halabi A, Stabholz A: Protection against endotoxic shock and lipopolysaccharideinduced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun 1996;64:825-828. (Pubitemid 26065554)
20. Hu JF, Song XY, Chu SF, Chen Y, Ji HJ, Chen XY, Yuan YH, Han N, Zhang JT, Chen NH: Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice. Brain Res 2011;1374:8-14.