Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells

European Journal of Pharmacology

Volumn 660, Issue 2-3, 2011, Pages 454-459

  Park, Chung Mu ^a   Jin, Kyong Suk ^b   Lee, Yong Woo ^a   Song, Young Sun ^a  

^a Inje University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Akt; Chicoric acid; Luteolin; NF B; Synergistic activity

Indexed keywords

CICHORIC ACID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INACTIVATION; ENZYME INHIBITION; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CAFFEIC ACIDS; CELL LINE; DINOPROSTONE; DRUG SYNERGISM; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUTEOLIN; MICE; NF-KAPPA B; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SUCCINATES;

EID: 79956093234     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.007     Document Type: Article

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