In situ fatty acid profile of femoral cancellous subchondral bone in osteoarthritic and fragility fracture females: Implications for bone remodelling

Bone

Volumn 51, Issue 2, 2012, Pages 218-223

  Humphries, J M ^a,b   Kuliwaba, J S ^a,b   Gibson, R J ^b   Fazzalari, N L ^a,b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Fatty acid; Femoral head; Omega fatty acids; Osteoarthritis; Osteoporosis

Indexed keywords

ARACHIDONIC ACID; FATTY ACID; GAMMA LINOLENIC ACID; MONOUNSATURATED FATTY ACID; N 9 FATTY ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; UNCLASSIFIED DRUG;

AGED; ARTICLE; AUTOPSY; BONE MATRIX; BONE REMODELING; CANCELLOUS BONE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FEMUR; FRACTURE; FRAGILITY FRACTURE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; NECK OF FEMUR FRACTURE; ORTHOPEDIC SURGERY; OSTEOARTHRITIS; SUBCHONDRAL BONE; SUPERIOR PRINCIPAL COMPRESSIVE REGION; SUPERIOR PRINCIPAL TENSILE REGION;

AGED; AGED, 80 AND OVER; BONE REMODELING; CASE-CONTROL STUDIES; COMPRESSIVE STRENGTH; FATTY ACIDS; FEMALE; FEMORAL NECK FRACTURES; FEMUR; FEMUR HEAD; HUMANS; MIDDLE AGED; OSTEOARTHRITIS; TENSILE STRENGTH;

EID: 84861989799     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.04.003     Document Type: Article

References (44)

1. Aspden R.A. Osteoarthritis: a problem of growth not decay?. Rheumatology 2008, 47:1452-1460.
2. Plumb M., Aspden R.A. High levels of fat and (n-6) fatty acids in cancellous bone in osteoarthritis. Lipids Health Dis 2004, 3:12.
3. Fazzalari N.L., Darracott J., Vernon-Roberts B. Histomorphometric changes in the trabecular structure of a selected stress region in the femur in patients with osteoarthritis and fracture of the femoral neck. Bone 1985, 6:125.
4. Meunier P., Aaron J., Edouard C., Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. Clin Orthop 1971, 80:147-154.
5. Verma S., Rajaratnam J., Denton J., Hoylan J., Byers R. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 2002, 55:693-698.
6. Yeung D., Lam S., Griffith J., Chan A., Chen Z., Tsang P., et al. Analysis of bone marrow fatty acids composition using high-resolution proton NMR spectroscopy. Chem Phys Lipids 2008, 151:103-109.
7. Griffith J., Yeung D., Antinio G., Wong S., Kwok T., Woo J., et al. Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation. Radiology 2006, 241:831-838.
8. Lund P., Abadi D., Mathies J. Lipid composition of normal human bone marrw as determined by coloumn chromatography. J Lipid Res 1962, 3:95-98.
9. Naveiras O., Nardi V., Wenzel P.L., Hauschka P.V., Fahey F., Daley G. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nat Lett 2009, 460:259-263.
10. Fritsch D., Allen T., Dodd C., Jewell D., Sixby K., Leventhal P., et al. A multi-centre study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. JAVMA 2010, 236:535-539.
11. Roush J., Cross A., Renberg W., Dodd C., Sixby K., Fritsch D., et al. Evaluation of the effect of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. JAVMA 2010, 236:67-73.
12. Roush J., Dodd C., Fritsch D., Allen T., Jewell D., Schoenherr W., et al. Multicentre veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. JAVMA 2010, 236:59-66.
13. Priante G., Bordin L., Musacchio E., Clari G., Baggio B. Fatty acids and cytokine mRNA expression in human osteoblastic cells: a specific effect of arachidonic acid. Clin Sci 2002, 102:403-409.
14. Toncheva A., Remichkova M., Ikonomova K., Dimitrova P., Ivanovska N. Inflammatory response in patients with active and inactive osteoarthritis. Rheumatol Int 2009, 29:1197-1203.
15. Yang C., McCoy K., Davis J., Schmidt-Supprian M., Sasaki Y., Faccio R., et al. NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis. PLoS One 2010, 5:e15383.
16. Lippiello L., Walsh T., Fienhold M. The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism 1991, 40:571-576.
17. Requirand P., Gibert P., Tramini P., Cristol J., Descomps B. Serum fatty acid imbalance in bone loss: example with periodontal disease. Clin Nutr 2000, 19:271-276.
18. Crane G., Fazzalari N., Parkinson I., Vernon-Roberts B. Age-related changes in femoral trabecular bone in arthrosis. Acta Orthop 1990, 61:421-426.
19. Fazzalari N., Vernon-Roberts B., Manthey B., Parkinson I. Relationship between changes in articular cartilage and bone in the femoral head in osteoarthritis of the hip. J Orthop Rheumatol 1990, 3:155-169.
20. Lin J., Grampp S., Link T., Kothari M., Newitt D., Felsenberg D., et al. Fractal analysis of proximal femur radiographs: correlation with biomechanical properties and bone mineral density. Osteoporos Int 1999, 9:516-524.
21. Dequeker J., Boonen S., Aerssens J., Westhovens R. Inverse relationship osteoarthritis-osteoporosis: what is the evidence? What are the consequences?. Br J Rheumatol 1996, 35:813-818.
22. Poulsen R.C., Moughan P.J., Kruger M.C. Long-chain polyunsaturated fatty acids and the regulation of bone metabolism. Exp Biol Med 2007, 232:1275-1288.
23. Westacott C. Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism. J Musculoskelet Neuronal Interact 2002, 2:507-509.
24. Dieppe P., Cushnaghan J., Young P., Kirwan J. Prediction of progression of joint space narrowing in osteoarthritis of the knee. Ann Rheum Dis 1993, 52:557-563.
25. Matsui H., Shimizu M., Tsuji H. Cartilage and subchondral bone interaction in osteoathritis of human knee joint: a histological and histomorphometric study. Microsc Res Tech 1997, 37:333-342.
26. Bellido M., Lugo L., Roman-Blas J., Castañeda S., Caeiro J., Dapia S., et al. Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Arthritis Res Ther 2010, 12:R152.
27. Prtizker K., Gay S., Jimenez S.A., Ostergaard K., Pelletier J.-P., Revell P.A., et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006, 14:13-29.
28. Makrides M., Neumann M., Gibson R. Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. EJCN 1996, 50:352-357.
29. Poulsen R.C., Wolber F.M., Moughan P.J., Kruger M.C. Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells. Prostaglandins Other Lipid Mediat 2008, 85:42-48.
30. Duque C. Bone and fat connection in ageing bone. Curr Opin Rheumatol 2008, 20:429-434.
31. Rosen C., Bouxsein M. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2006, 2:35-43.
32. Watkins B., Li Y., Lippman H., Seifert M. Omega-3 polyunsaturated fatty acids and skeletal health. Exp Biol Med 2001, 226:485-497.
33. 2 and parathyroid hormone on osteoprotogerin and RANKL secretion by MC3T3-E1 osteoblast-like cells. J Nutr Biochem 2007, 18:54-63.
34. Roche H. Fatty acids and the metabolic syndrome. Proc Nutr Soc 2005, 64:23-29.
35. Forman B., Tontonog P., Jasmine C., Brun P., Spigelman B., Evan R. 5-deoxy-δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR γ. Cell 1995, 83:803-812.
36. Vara Prasad S., Jeya Kumar S., Uday Kumar P., Qadri S., Vajreswari A. Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue. Lipids Health Dis 2010, 9:111.
37. Griffith J., Yeung D., Ahuja A., Choy C., Wong M.Y., Lam S., et al. A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density. Bone 2009, 44:1092-1096.
38. Darlington L., Stone T. Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. Br J Nutr 2001, 85:251-269.
39. James M., Gibson R., Neumann M., Cleland L. Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis. J Exp Med 1993, 178:2261-2265.
40. Adkisson H., Risener F., Zarrinkar P., Walla M., Christie W., Wuthier R. Unique fatty acid composition of normal cartilage: discovery of high levels of n-9 eicosatrienoic acid and low levels of n-6 polyunsaturated fatty acids. FASEB 1991, 5:344-353.
41. Nuttall M., Gimble J. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 2004, 4:290-294.
42. Nuttall M., Patton A., Olivera D., Nadeau D., Gowen M. Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. J Bone Miner Res 1998, 13:371-382.
43. Pittenger M., Mackay A., Beck S., Jaiswal R., Douglas R., Mosca J., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 248:143-147.
44. Aspden R., Scheven B., Hutchison J. Osteoarthritis is a systemic disorder involving stromal cell differentiation and lipid metabolism. Lancet 2001, 357:1118-1120.