NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Yang, Chang ^a   McCoy, Kathleen ^a   Davis, Jennifer L ^a   Schmidt Supprian, Marc ^b   Sasaki, Yoshiteru ^c   Faccio, Roberta ^a   Novack, Deborah Veis ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; I KAPPA B KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSOZYME; LYSOZYME M, MOUSE; NF KAPPA B KINASE; NF-KAPPA B KINASE; OSTEOCALCIN; PROTEIN SERINE THREONINE KINASE; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE TURNOVER; CELL FUNCTION; CELL LINEAGE; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME STABILITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; ARTHRITIS; BINDING SITE; BLOOD; BONE DENSITY; BONE MARROW CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; MACROPHAGE; MALE; METABOLISM; OSTEOCLAST; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS MUSCULUS;

ANIMALS; ARTHRITIS; BINDING SITES; BLOTTING, WESTERN; BONE DENSITY; BONE MARROW CELLS; CATHEPSIN K; CELLS, CULTURED; FEMALE; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; MURAMIDASE; NF-KAPPA B; OSTEOCALCIN; OSTEOCLASTS; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF RECEPTOR-ASSOCIATED FACTOR 3;

EID: 78149488881     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015383     Document Type: Article

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