Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist

European Journal of Pharmacology

Volumn 316, Issue 2-3, 1996, Pages 277-286

  De Campos, Rafael O P ^a   Alves, Ricardo V ^a   Kyle, Donald J ^b   Chakravarty, Sarvajit ^b   Mavunkel, Babu J ^b   Calixto, João B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b Scios Nova Inc   (United States)

Author keywords

Antinociception; Bradykinin; Bradykinin B1 receptor; Bradykinin B2 receptor; Capsaicin; Formalin; Locking; Mouse; NPC 18521; Paw oedema; Rat; Writhing test

Indexed keywords

ACETIC ACID; ACETYLCHOLINE; BRADYKININ; BRADYKININ ANTAGONIST; BRADYKININ RECEPTOR AGONIST; BRADYKININ[1-8]; CARRAGEENAN; COMPOUND 48-80; CYPROHEPTADINE; ESCHERICHIA COLI ENDOTOXIN; ICATIBANT; KAOLIN; PSEUDOPEPTIDE; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; EDEMA; INTRADERMAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRADYKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; IMIDAZOLES; MALE; MICE; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; SPIRO COMPOUNDS;

EID: 0030571549     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00661-9     Document Type: Article

References (43)

1. Bhoola, K.D., C.D. Figueroa and K. Worthy, 1992, Bioregulation of kinins: kallikreins, kininogens and kininases, Pharmacol. Rev. 44, 1.
2. Burch, R.M. and C. DeHaas, 1990, A bradykinin antagonist inhibits carrageenan edema in rats, Naunyn-Schmiedeberg's Arch. Pharmacol. 342, 189.
3. 2 receptors in bradykinin-induced rat paw oedema, Br. J. Pharmacol. 113, 1005.
4. 1 kinin receptors mediating paw edema and formalin-induced nociception. Modulation by glucocorticoids, Can. J. Physiol. Pharmacol. 73. 812.
5. 9-BK-induced rat paw oedema by systemic treatment with bacterial endotoxin, Br. J. Pharmacol. 117. 798.
6. 2 receptor, Pept. Res. 8, 16.
7. Chapman, V. and A.H. Dickenson, 1992, The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat, Eur. J. Pharmacol. 219, 427.
8. Collier, H.O.J., L.C. Dinneen, C.A. Johnson and C. Schneider, 1968, The abdominal constriction response and its suppression by analgesic drugs in the mouse, Br. J. Pharmacol. 32, 295.
9. 2 kinin receptors in formalin-induced nociceptive response in the mouse. Br. J. Pharmacol. 110, 193.
10. 2 bradykinin receptor antagonist NPC 18688 in mice, Br. J. Pharmacol. 117, 552.
11. Costello, A.H. and K.M. Hargreaves, 1989, Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist, Eur. J. Pharmacol. 171, 259.
12. Damas, J. and G. Remacle-Volon, 1992, Influence of a long-acting bradykinin antagonist, Hoe 140, on some acute inflammatory reactions in the rat, Eur. J. Pharmacol. 211, 81.
13. Damas, J., V. Bourdon, G. Remacle-Volon and Albert Adam, 1990, Kinins and peritoneal exudates induced by carrageenin and zymosan in rats, Br. J. Pharmacol. 101, 418.
14. Dray, A. and M. Perkins, 1993, Bradykinin and inflammatory pain. Trends Neurosci. 16, 99.
15. Eggerickx, D., E. Raspe, D. Bertrand, G. Vassart and M. Parmentier. 1992, Molecular cloning, functional expression and pharmacological characterization of human bradykinin B2 receptor gene, Biochem. Biophys. Res. Commun. 187, 1306.
16. Farmer, S.G. and R.M. Burch, 1992, Biochemical and molecular pharmacology of kinin receptors, Annu. Rev. Pharmacol. Toxicol. 32, 511.
17. Geppetti, P., 1993, Sensory neuropeptide released by bradykinin; mechanisms and pathophysiological implications, Regul. Pept. 47, 1.
18. Haley, J.E., A.H. Dickenson and M. Schachter, 1989, Electrophysiological evidence for a role of bradykinin in chemical nociception in the rat, Neurosci. Lett. 97, 198.
19. Hall, J.M., 1992, Bradykinin receptors: pharmacological properties and biological roles, Pharmacol. Ther. 56, 131.
20. Heapy, C.G., J.S. Shaw and S.C. Farmer, 1993, Differential sensitivity of antinociceptive assays to the bradykinin antagonist Hoe 140, Br. J. Pharmacol. 108, 209.
21. Hess, J.F., J.A. Borkowski, G.S. Young, C.D. Strader and R.W. Ransom, 1992, Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor, Biochem. Biophys. Res. Commun. 184, 260.
22. Hess, J.F., J.A. Borkowski, T. MacNeil, G.Y. Stonesifer, J. Fraher, C.D. Strader and R.W. Ransom, 1994. Differential pharmacology of cloned human and mouse B2 bradykinin receptors, Mol. Pharmacol. 45, 1.
23. Hock, F.J., K. Wirth, U. Albus, W. Linz, H.J. Gerhards, G. Wiemer, S. Henke, G. Breipohl, W. Konig, J. Knolle and B.A. Scholkens, 1991, Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br. J. Pharmacol. 102, 769.
24. Hunskaar, S. and K. Hole, 1987, The formalin test in mice: dissociation between inflammatory and non-infiamatory pain. Pain 30, 103.
25. Kindgen-Milles, D, and W. Klement, 1992, Pain and inflammation evoked in human skin by bradykinin receptor antagonists, Eur. J. Pharmacol. 218, 183.
26. Kyle, D.J., 1994, Structural features of the bradykinin receptor as determined by computer simulations, mutagenesis experiments and conformationally constrained ligants: establishing the framework for the design of new antagonists, Braz. J. Med. Biol. Res. 27, 1757.
27. Kyle, D.J., 1995, Kinin antagonists: the recent history and future prospects. Drug News Perspect, 1, 603.
28. Kyle, D.J. and R.M. Burch, 1992, Recent advances toward novel bradykinin antagonists, Drugs Future 17, 305.
29. Lembeck, F., T. Griesbacher, M. Eckhardt, S. Henke, G. Breipohl and J. Knolle, 1991, New, long-acting, potent bradykinin antagonists, Br. J. Pharmacol. 102, 297.
30. Marceau, F., 1995, Kinin B1 receptors: a review, Immunopharmacology 30, 1.
31. Martins, M.A., C.P. Pasquale, P.M. E Silva, R.S. Cordeiro and B.B. Vargaftig, 1990, Eosinophil accumulation in the rat pleural cavity after mast cell stimulation with compound 48/80 involves protein synthesis and is selectively suppressed by dexamethasone. Int. Arch. Allergy Appl. Immunol. 92, 416.
32. Mavunkel, B.J., Zhijian Lu, R.R. Goehring, Songfeng Lu, S. Chakravarty, J. Perumattam, E.A. Novotny, M, Connolly, H. Valentine and D.J. Kyle, 1996, Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system, J. Med. Chem. 39, 3169.
33. McEachern, A.E., E.R. Shelton, S. Bhakta, R. Obernolte, C. Bach, P. Zuppan, J, Fujisaki, R.W. Aldrish and K. Jarnagin, 1991, Expression cloning of a rat B2 bradykinin receptor. Proc. Natl. Acad. Sci. USA 88, 7724.
34. Menke, J.G., J.A. Borkowski, K.K. Bierilo, T. MacNeil, A.W. Derrick, K.A. Schneck, R.W. Ransom, C.D. Strader, D.L. Linemeyer and J.F. Hess, 1994, Expression cloning of a human B1 bradykinin receptor, J. Biol. Chem. 269, 21583.
35. Powell, S.J., G. Slynn, C. Thomas, B. Hopkins, I. Briggs and A. Graham, 1993, Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14, Genomics 15, 435.
36. Randall, L.O. and J.J. Selitto, 1957, A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther. 111, 409.
37. Sakurada, T., K. Katsumata, K. Tan-no, S. Sakurada and K. Kisara, 1992, The capsaicin test in mice for evaluating tackykinin antagonists in the spinal cord, Neuropharmacology 31, 1279.
38. Shibata, M., T. Ohkubo, H. Takahashi and R. Inoki, 1986, Interaction of bradykinin with substance P on vascular permeability and pain response, Jpn. J. Pharmacol. 41, 427.
39. Steranka, L.R. and R.M. Burch, 1991, Bradykinin antagonists in pain and inflammation, in: Bradykinin Antagonists: Basical Clinical Research, ed. R.M. Burch (Marcel-Dekker, New York, NY) p. 171.
40. Steranka, L.R., D.C. Manning, C.J. Dehaas, J.W. Ferkany, S.A. Borosky, J.R. Connor, R.J. Vavrek, J.M. Stewart and S.H. Snyder, 1988a, Bradykinin as a pain mediator: receptors are localized to sensory neurons and antagonists have analgesic actions, Proc. Natl. Acad. Sci. USA 85, 3245.
41. Steranka, L.R., R.M. Burch, R. Vavrek, J.M. Stewart and S.J. Enna, 1988b, Multiple bradykinin receptors: results of studies using a novel class of receptor antagonists, Adv. Exp. Med. Biol. 236, 111.
42. Wirth, K., F.J. Hock, U. Albus, W. Linz, H.G. Alpermann, H. Anagnostopoulos, S. Henke, G. Breipohl, W. Konig, J. Knolle and B.A. Scholkens, 1991, Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies, Br. J. Pharmacol. 102, 774.
43. Zimmermann, M., 1983, Ethical guidelines for investigations of experimental pain in conscious animals, Pain 16, 109.