Processing of carbamazepine - PEG 4000 solid dispersions with supercritical carbon dioxide: Preparation, characterisation, and in vitro dissolution

International Journal of Pharmaceutics

Volumn 222, Issue 1, 2001, Pages 129-138

  Moneghini, M ^a   Kikic, I ^a   Voinovich, D ^a   Perissutti, B ^a   Filipovic Grcic J ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Carbamazepine; Gas antisolvent crystallisation; PEG 4000; Physico chemical characterisation; Solid dispersions; Supercritical fluids

Indexed keywords

CARBAMAZEPINE; CARBON DIOXIDE; DRUG CARRIER; MACROGOL 4000; SUPERCRITICAL CARBON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED RELEASE FORMULATION; CRYSTAL STRUCTURE; DISPERSION; DRUG ABSORPTION; DRUG DOSAGE FORM; DRUG SOLUBILITY; IN VITRO STUDY; MOLECULAR SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLID STATE; TECHNIQUE; THERMAL ANALYSIS;

CARBAMAZEPINE; CRYSTALLIZATION; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 0035800251     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00711-6     Document Type: Article

References (32)

1. Solid dispersions - Fundamentals and examples
2. Polyethylene glycols and drug release
3. High-pressure phase equilibria of poly(ethylene glycol)-carbon dioxide systems
4. Preformulation studies on solid dispersions containing triamterene or temazepam in polyethylene glycols or Gelucire 44/14 for liquid filling of hard gelatin capsules
5. Carbamazepine and polyethylene glycol solid dispersion preparation, in vitro dissolution, and characterisation
6. Gas antisolvent recrystallization: A new process to recrystallize compounds in supercritical fluids
7. Solubility parameters as predictors of miscibility in solid dispersions
8. A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids
9. A swellable polymer as carbamazepine dissolution rate enhancer
10. Micronization of drugs using supercritical carbon dioxide
11. Fractional crystallization by supercritical antisolvent technique: Theory and experimental test
12. Crystallization and fusion of self-seeded polymers
13. Relations between several polymorphic forms and the duhydrate of carbamazepine
14. Pharmacokinetics of carbamazepine in normal man
15. Compression behaviour and tensile strength of heat treated polyethylene glycols
16. Physicochemical properties and X-ray structural studies of the trigonal polymorph of carbamazepine
17. Influence of polyethylene glycol 4000 on the polymorphic forms of diflunisal
18. 3
19. Supercritical Antisolvent Precipitation: Its application to microparticle generation and products fractionation
20. Supercritical Anti-solvent Precipitation of micro- and nano-particles
21. Influence of polymorphism on the Young's modulus and yield stress of carbamazepine, sulfathiazole and sulfanilamide
22. Solid-state of polymorphic drug: Carbamazepine
23. 2-philic antisolvents
24. 2
25. Solid dispersions of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs
26. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide
27. Pharmaceutical processing with supercritical carbon dioxide
28. Size controlled production of biodegradable microparticles with supercritical gases
29. Phase equilibrium (solid-liquid-gas) in polyethyleneglycol-carbon dioxide
30. Measurement and modelling of high-pressure phase equilibria in the systems polyethyleneglycol (PEG)-propane, PEG-nitrogen, PEG-carbon dioxide
31. Supercritical fluids ease drug delivery