메뉴 건너뛰기




Volumn 118, Issue 12, 2012, Pages 3026-3035

Long-term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer

Author keywords

Chemoradiation; Gemcitabine; Locally advanced pancreatic cancer; Neoadjuvant chemotherapy; Resection; Survival

Indexed keywords

BEVACIZUMAB; CAPECITABINE; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE;

EID: 84861894707     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26633     Document Type: Article
Times cited : (58)

References (38)
  • 3
    • 0023722682 scopus 로고
    • Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: comparison of combined modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst. 1988;80:751-755.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 751-755
  • 4
    • 0018347080 scopus 로고
    • A multi-institutional comparative trial of radiation therapy alone and in combination with 5-fluorouracil for locally unresectable pancreatic carcinoma
    • Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. A multi-institutional comparative trial of radiation therapy alone and in combination with 5-fluorouracil for locally unresectable pancreatic carcinoma. Ann Surg. 1979;189:205-208.
    • (1979) Ann Surg , vol.189 , pp. 205-208
  • 5
    • 50849115450 scopus 로고    scopus 로고
    • Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study
    • Chauffert B, Mornex F, Bonnetain F, et al. Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study. Ann Oncol. 2008;19: 1592-1599.
    • (2008) Ann Oncol , vol.19 , pp. 1592-1599
    • Chauffert, B.1    Mornex, F.2    Bonnetain, F.3
  • 7
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;63:457-481.
    • (1958) J Am Stat Assoc , vol.63 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 8
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox DR. Regression models and life tables. J R Stat Soc B. 1972;34:187-220.
    • (1972) J R Stat Soc B , vol.34 , pp. 187-220
    • Cox, D.R.1
  • 10
    • 58149383101 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: Results of a prospective phase II trial
    • Heinrich S, Schafer M, Weber A, et al. Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: results of a prospective phase II trial. Ann Surg. 2008;248: 1014-1022.
    • (2008) Ann Surg , vol.248 , pp. 1014-1022
    • Heinrich, S.1    Schafer, M.2    Weber, A.3
  • 12
    • 67649207663 scopus 로고    scopus 로고
    • Pretreatment assessment of resectable and borderline resectable pancreatic cancer: Expert consensus statement
    • Callery MP, Chang KJ, Fishman EK, et al. Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement. Ann Surg Oncol. 2009; 16:1727-1733.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1727-1733
    • Callery, M.P.1    Chang, K.J.2    Fishman, E.K.3
  • 14
    • 74649084777 scopus 로고    scopus 로고
    • A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer
    • Morganti AG, Massaccesi M, La Torre G, et al. A systematic review of resectability and survival after concurrent chemoradiation in primarily unresectable pancreatic cancer. Ann Surg Oncol. 2010;17:194-205.
    • (2010) Ann Surg Oncol , vol.17 , pp. 194-205
    • Morganti, A.G.1    Massaccesi, M.2    La Torre, G.3
  • 15
    • 19944431530 scopus 로고    scopus 로고
    • Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer
    • Willett CG, Del Castillo CF, Shih HA, et al. Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer. Ann Surg. 2005;241:295-299.
    • (2005) Ann Surg , vol.241 , pp. 295-299
    • Willett, C.G.1    Del Castillo, C.F.2    Shih, H.A.3
  • 16
    • 79955512732 scopus 로고    scopus 로고
    • Neoad-juvant therapy is associated with improved survival in resectable pancreatic adenocarcinoma
    • Artinyan A, Anaya DA, McKenzie S, Ellenhorn JD, Kim J. Neoad-juvant therapy is associated with improved survival in resectable pancreatic adenocarcinoma. Cancer. 2011;117: 2044-2049.
    • (2011) Cancer , vol.117 , pp. 2044-2049
    • Artinyan, A.1    Anaya, D.A.2    McKenzie, S.3    Ellenhorn, J.D.4    Kim, J.5
  • 17
    • 43049106807 scopus 로고    scopus 로고
    • Borderline resectable pancreatic cancer: The importance of this emerging stage of disease
    • Katz MH, Pisters PW, Evans DB, et al. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg. 2008;206:833-846.
    • (2008) J Am Coll Surg , vol.206 , pp. 833-846
    • Katz, M.H.1    Pisters, P.W.2    Evans, D.B.3
  • 18
    • 79959928329 scopus 로고    scopus 로고
    • Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer
    • Patel M, Hoffe S, Malafa M, et al. Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer. J Surg Oncol. 2011;104: 155-161.
    • (2011) J Surg Oncol , vol.104 , pp. 155-161
    • Patel, M.1    Hoffe, S.2    Malafa, M.3
  • 19
    • 75449086813 scopus 로고    scopus 로고
    • Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer
    • McClaine RJ, Lowy AM, Sussman JJ, Schmulewitz N, Grisell DL, Ahmad SA. Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer. HPB (Oxford). 2010;12:73-79.
    • (2010) HPB (Oxford) , vol.12 , pp. 73-79
    • McClaine, R.J.1    Lowy, A.M.2    Sussman, J.J.3    Schmulewitz, N.4    Grisell, D.L.5    Ahmad, S.A.6
  • 20
    • 77953588071 scopus 로고    scopus 로고
    • Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 or older
    • Miyamoto DT, Mamon HJ, Ryan DP, et al. Outcomes and tolerability of chemoradiation therapy for pancreatic cancer patients aged 75 or older. Int J Radiat Oncol Biol Phys. 2010;77:1171-1177.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , pp. 1171-1177
    • Miyamoto, D.T.1    Mamon, H.J.2    Ryan, D.P.3
  • 21
    • 33845614902 scopus 로고    scopus 로고
    • Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancer
    • DOI 10.1016/j.ijrobp.2006.07.1390, PII S0360301606030021
    • Krzyzanowska MK, Earle CC, Kuntz KM, Weeks JC. Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys. 2007;67: 211-218. (Pubitemid 44959514)
    • (2007) International Journal of Radiation Oncology Biology Physics , vol.67 , Issue.1 , pp. 211-218
    • Krzyzanowska, M.K.1    Earle, C.C.2    Kuntz, K.M.3    Weeks, J.C.4
  • 23
    • 80255131310 scopus 로고    scopus 로고
    • Induction gemcitabine and stereotactic body radiotherapy for locally advanced nonmetastatic pancreas cancer
    • published online ahead of print June 8, 2011
    • Mahadevan A, Miksad R, Goldstein M, et al. Induction gemcitabine and stereotactic body radiotherapy for locally advanced nonmetastatic pancreas cancer. Int J Radiat Oncol Biol Phys. [published online ahead of print June 8, 2011.]
    • Int J Radiat Oncol Biol Phys
    • Mahadevan, A.1    Miksad, R.2    Goldstein, M.3
  • 24
    • 79952779931 scopus 로고    scopus 로고
    • A phase I study of erlotinib, bevacizumab, and external beam radiation therapy for patients with localized pancreatic carcinoma
    • [abstract]. Abstract 281
    • Czito BG, Willett C, Kennedy-Newton P, Tyler DS, Hurwitz H, Uronis HE. A phase I study of erlotinib, bevacizumab, and external beam radiation therapy for patients with localized pancreatic carcinoma [abstract]. J Clin Oncol. 2011;29(suppl 4). Abstract 281.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Czito, B.G.1    Willett, C.2    Kennedy-Newton, P.3    Tyler, D.S.4    Hurwitz, H.5    Uronis, H.E.6
  • 25
    • 70249130566 scopus 로고    scopus 로고
    • Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411
    • Crane CH, Winter K, Regine WF, et al. Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411. J Clin Oncol. 2009;27:4096-4102.
    • (2009) J Clin Oncol , vol.27 , pp. 4096-4102
    • Crane, C.H.1    Winter, K.2    Regine, W.F.3
  • 28
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • DOI 10.1200/JCO.2004.12.040
    • Xiong HQ, Rosenberg A, LoBuglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol. 2004;22:2610-2616. (Pubitemid 41103748)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.13 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 29
    • 84861860974 scopus 로고    scopus 로고
    • Multi-institutional phase II trial of induction cetuximab, gemcitabine, and oxaliplatin, followed by radiotherapy with concurrent capecitabine, and cetuximab, for locally advanced pancreatic adenocarcinoma
    • Abstract presented at the Abstract 132
    • Crane CH, Varadhachary GR, Javle MM, et al. Multi-institutional phase II trial of induction cetuximab, gemcitabine, and oxaliplatin, followed by radiotherapy with concurrent capecitabine, and cetuximab, for locally advanced pancreatic adenocarcinoma. Abstract presented at the ASCO Gastrointestinal Cancers Symposium; January 22-24, 2010; Orlando, Fla. Abstract 132.
    • ASCO Gastrointestinal Cancers Symposium; January 22-24, 2010; Orlando, Fla.
    • Crane, C.H.1    Varadhachary, G.R.2    Javle, M.M.3
  • 30
    • 79952799202 scopus 로고    scopus 로고
    • Phase I study of sorafenib with gemcitabine-based radiotherapy in patients with locally advanced unresectable pancreatic cancer
    • [abstract]. Abstract 4139
    • Anderson S, Cardenes HR, Akisik F, et al. Phase I study of sorafenib with gemcitabine-based radiotherapy in patients with locally advanced unresectable pancreatic cancer [abstract]. J Clin Oncol. 2010;28(suppl 15). Abstract 4139.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15
    • Anderson, S.1    Cardenes, H.R.2    Akisik, F.3
  • 32
    • 0036719234 scopus 로고    scopus 로고
    • Gemcitabine, paclitaxel, and radiation for locally advanced pancreatic cancer: A phase I trial
    • Safran H, Dipetrillo T, Iannitti D, et al. Gemcitabine, paclitaxel, and radiation for locally advanced pancreatic cancer: a phase I trial. Int J Radiat Oncol Biol Phys. 2002;54: 137-141.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 137-141
    • Safran, H.1    Dipetrillo, T.2    Iannitti, D.3
  • 36
    • 22144444482 scopus 로고    scopus 로고
    • A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282
    • DOI 10.1016/j.ijrobp.2004.12.074, PII S0360301605000969
    • Cohen SJ, Dobelbower R Jr, Lipsitz S, et al. A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282. Int J Radiat Oncol Biol Phys. 2005;62: 1345-1350. (Pubitemid 40982053)
    • (2005) International Journal of Radiation Oncology Biology Physics , vol.62 , Issue.5 , pp. 1345-1350
    • Cohen, S.J.1    Dobelbower Jr., R.2    Lipsitz, S.3    Catalano, P.J.4    Sischy, B.5    Smith, T.J.6    Haller, D.G.7
  • 37
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 38
    • 84861872063 scopus 로고    scopus 로고
    • Pilot study of neoadjuvant FOLFIRINOX in unresectable locally advanced pancreatic carcinoma
    • [abstract]. Abstract 324
    • Hosein PJ, Kawamura C, Macintyre J, et al. Pilot study of neoadjuvant FOLFIRINOX in unresectable locally advanced pancreatic carcinoma [abstract]. J Clin Oncol. 2011;29(suppl 4). Abstract 324.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Hosein, P.J.1    Kawamura, C.2    Macintyre, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.