Induction gemcitabine and stereotactic body radiotherapy for locally advanced nonmetastatic pancreas cancer

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 4, 2011, Pages

  Mahadevan, Anand ^a   Miksad, Rebecca ^a   Goldstein, Michael ^a   Sullivan, Ryan ^a   Bullock, Andrea ^a   Buchbinder, Elizabeth ^a   Pleskow, Douglas ^a   Sawhney, Mandeep ^a   Kent, Tara ^a   Vollmer, Charles ^a   Callery, Mark ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chemotherapy; Gemcitabine; Locally advanced pancreatic cancer; Stereotactic body radiotherapy

Indexed keywords

GEMCITABINE; LOCAL CONTROL; LOCAL THERAPY; METASTATIC DISEASE; OVERALL SURVIVAL; PANCREAS CANCER; PANCREATIC CANCERS; PROGRESSION FREE SURVIVAL; STEREOTACTIC BODY RADIOTHERAPY; STRATEGY USE;

CHEMOTHERAPY; DIAGNOSIS; DISEASE CONTROL; DISEASES; PATHOLOGY; RADIOTHERAPY;

DRUG PRODUCTS;

ANTIEMETIC AGENT; GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL OBSTRUCTION; HUMAN; MALE; METASTASIS; MULTIPLE CYCLE TREATMENT; NAUSEA; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; RADIATION SICKNESS; RETROSPECTIVE STUDY; STEREOTACTIC BODY RADIATION THERAPY;

ADULT; AGED; AGED, 80 AND OVER; CA-19-9 ANTIGEN; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INDUCTION CHEMOTHERAPY; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS; RADIATION-SENSITIZING AGENTS; RADIOSURGERY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RETROSPECTIVE STUDIES;

EID: 80255131310     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.04.045     Document Type: Article

References (43)

1. A. Jemal, R. Siegel, and J. Xu Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. C.G. Willett, B.G. Czito, and J.C. Bendell Locally advanced pancreatic cancer J Clin Oncol 23 2005 4538 4544 (Pubitemid 46196584)
3. S.F. Sener, A. Fremgen, and H.R. Menck Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database J Am Coll Surg 189 1999 1 7 (Pubitemid 29307735)
4. A.W. Blackstock, J.E. Tepper, and D. Niedwiecki Cancer and leukemia group B (CALGB) 89805: Phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreas Int J Gastrointest Cancer 34 2003 107 116 (Pubitemid 39279726)
5. C.H. Crane, L.M. Ellis, and J.L. Abbruzzese Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer J Clin Oncol 24 2006 1145 1151 (Pubitemid 46638812)
6. A. Magnino, M. Gatti, and P. Massucco Phase II trial of primary radiation therapy and concurrent chemotherapy for patients with locally advanced pancreatic cancer Oncology 68 2005 493 499 (Pubitemid 41160982)
7. M.T. Milano, S.J. Chmura, and M.C. Garofalo Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: Toxicity and clinical outcome Int J Radiat Oncol Biol Phys 59 2004 445 453 (Pubitemid 38622599)
8. G. Mishra, J. Butler, and C. Ho Phase II trial of induction gemcitabine/CPT-11 followed by a twice-weekly infusion of gemcitabine and concurrent external beam radiation for the treatment of locally advanced pancreatic cancer Am J Clin Oncol 28 2005 345 350 (Pubitemid 41099538)
9. T. Okusaka, Y. Ito, and H. Ueno Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer Br J Cancer 91 2004 673 677 (Pubitemid 39141622)
10. T. Rich, J. Harris, and R. Abrams Phase II study of external irradiation and weekly paclitaxel for nonmetastatic, unresectable pancreatic cancer: RTOG-98-12 Am J Clin Oncol 27 2004 51 56 (Pubitemid 38176292)
11. H. Shinchi, S. Takao, and H. Noma Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer Int J Radiat Oncol Biol Phys 53 2002 146 150 (Pubitemid 34465818)
12. B. Chauffert, F. Mornex, and F. Bonnetain Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study Ann Oncol 19 2008 1592 1599
13. F. Huguet, T. Andre, and P. Hammel Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase II and III studies J Clin Oncol 25 2007 326 331 (Pubitemid 350003022)
14. A.C. Koong, E. Christofferson, and Q.T. Le Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 63 2005 320 323 (Pubitemid 41317146)
15. A.C. Koong, Q.T. Le, and A. Ho Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 58 2004 1017 1021 (Pubitemid 38314781)
16. D. Schellenberg, K.A. Goodman, and F. Lee Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 72 2008 678 686
17. F. Polistina, G. Costantin, and F. Casamassima Unresectable locally advanced pancreatic cancer: A multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration Ann Surg Oncol 17 2010 2092 2101
18. M.S. Didolkar, C.W. Coleman, and M.J. Brenner Image-guided stereotactic radiosurgery for locally advanced pancreatic adenocarcinoma results of first 85 patients J Gastrointest Surg 14 2010 1547 1559
19. J.C. Rwigema, S.D. Parikh, and D.E. Heron Stereotactic body radiotherapy in the treatment of advanced adenocarcinoma of the pancreas Am J Clin Oncol 34 2011 63 69
20. A. Mahadevan, S. Jain, and M. Goldstein Stereotactic body radiotherapy and gemcitabine for locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 78 2010 735 742
21. NCCN practice guidelines for pancreatic cancer. Vol 1; 2009. Available at http://www.nccn.org/professionals/physician-gls/f-guidelines.asp. Accessed June 2, 2011.
22. C.G. Moertel, S. Frytak, and R.G. Hahn Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group Cancer 48 1981 1705 1710 (Pubitemid 11022870)
23. M.A. Tempero, J.P. Arnoletti, and S. Behrman Pancreatic adenocarcinoma J Natl Compr Canc Netw 8 2010 972 1017
24. R. Kim, and M.W. Saif Is there an optimal neoadjuvant therapy for locally advanced pancreatic cancer? JOP 8 2007 279 288 (Pubitemid 46876786)
25. A.H. Ko, and C.H. Crane Radiation therapy in operable and locally advanced pancreatic cancer J Natl Compr Canc Netw 8 2010 1022 1031
26. E. Poplin, Y. Feng, and J. Berlin Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group J Clin Oncol 27 2009 3778 3785
27. H.L. Kindler, D. Niedzwiecki, and D. Hollis Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303) J Clin Oncol 28 2010 3617 3622
28. Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. Gastrointestinal Tumor Study Group J Natl Cancer Inst 80 1988 751 755
29. Rich T, Myerson R, Harris J, et al. A randomized phase II trial of weekly gemcitabine (G), paclitaxel (P), and external irradiation followed by the farnesyl transferase inhibitor R115777 (NSC#702818) for locally advanced pancreatic cancer (RTOG 0020). p. A-121. In Proceedings of the ASCO Gastrointestinal Cancers Symposium, San Francisco, CA, Month Day, 2006. Abstract 121. Available onilne at http://www.asco.org/ASCOv2/Meetings/Abstracts? &vmview=abst-detail-view&confID=41&abstractID=43. Accessed June 2, 2011.
30. C.H. Crane, K. Winter, and W.F. Regine Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411 J Clin Oncol 27 2009 4096 4102
31. P.J. Loehrer, M.E. Powell, and H.R. Cardenes A randomized phase III study of gemcitabine in combination with radiation therapy versus gemcitabine alone in patients with localized, unresectable pancreatic cancer J Clin Oncol 26 2008 Abstract 4506
32. D.T. Chang, D. Schellenberg, and J. Shen Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas Cancer 115 2009 665 672
33. M. Hoyer, H. Roed, and L. Sengelov Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma Radiother Oncol 76 2005 48 53 (Pubitemid 41096514)
34. C.G. Moertel, D.S. Childs Jr., and R.J. Reitemeier Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer Lancet 2 1969 865 867
35. A multi-institutional comparative trial of radiation therapy alone and in combination with 5-fluorouracil for locally unresectable pancreatic carcinoma. The Gastrointestinal Tumor Study Group Ann Surg 189 1979 205 208
36. D.J. Klaassen, J.M. MacIntyre, and G.E. Catton Treatment of locally unresectable cancer of the stomach and pancreas: A randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil - -An Eastern Cooperative Oncology Group study J Clin Oncol 3 1985 373 378 (Pubitemid 15132005)
37. S. Krishnan, V. Rana, and N.A. Janjan Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy Cancer 110 2007 47 55 (Pubitemid 46986417)
38. A.H. Ko, J.M. Quivey, and A.P. Venook A phase II study of fixed-dose rate gemcitabine plus low-dose cisplatin followed by consolidative chemoradiation for locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 68 2007 809 816 (Pubitemid 46818742)
39. H.L. Kindler, D. Niedzwiecki, and D.R. Hollis A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (b) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of cancer and leukemia group B (CALGB) 80303. Abstract A108 J Clin Oncol 26 2007 Supp. 1; A108
40. E. Poplin, D.E. Levy, and J. Berlin Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion[FDR]) versus gemcitabine + oxaliplatin(GEMOX) in patients with advanced pancreatic cancer (E6201) J Clin Oncol 24 2006 LBA4004
41. A. Duffy, J. Kortmansky, and G.K. Schwartz A phase I study of erlotinib in combination with gemcitabine and radiation in locally advanced, nonoperable pancreatic adenocarcinoma Ann Oncol 19 2008 86 91
42. E. Ben-Josef, K. Griffith, and I.R. Francis Phase I radiation dose-escalation trial of intensity-modulated radiotherapy (IMRT) with concurrent fixed dose-rate gemcitabine (FDR-G) for unresectable pancreatic cancer. Abstract 4602 J Clin Oncol 27 2009 Supp 1; Abstract 4602.
43. Crane CH, varadhachary GR, Javle MM, et al. Multi-institutional phase II trial of induction cetuximab, gemcitabine, and oxaliplatin, followed by radiotherapy with concurrent capecitabine, and cetuximab, for locally advanced pancreatic adenocarcinoma (LAPC). In: Proceedings of the ASCO Gastrointestinal Cancers Symposium, Orlando, FL, Date range, 2010. p. 132.