A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282

International Journal of Radiation Oncology Biology Physics

Volumn 62, Issue 5, 2005, Pages 1345-1350

  Cohen, Steven J ^a   Dobelbower Jr , Ralph ^b   Lipsitz, Stuart ^c   Catalano, Paul J ^c   Sischy, Benjamin ^d   Smith, Thomas J ^e,f   Haller, Daniel G ^g  

^a FOX CHASE CANCER CENTER   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

^e TUFTS MEDICAL CENTER   (United States)

^f The Everett Clinic   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 fluorouracil; Chemotherapy; Locally advanced; Pancreatic cancer; Radiotherapy

Indexed keywords

DISEASES; ONCOLOGY; PATIENT TREATMENT; TOXICITY; TUMORS;

ADENOCARCINOMA OF THE PANCREAS; DISEASE FREE SURVIVAL TIME; EXTERNAL BEAM RADIOTHERAPY; PANCREATIC CANCER;

RADIOTHERAPY;

FLUOROURACIL; MITOMYCIN C;

ADULT; AGED; ARTICLE; BEAM THERAPY; BLEEDING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FEMALE; GASTROINTESTINAL TOXICITY; HEMATOLOGIC DISEASE; HUMAN; INFECTION; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC DISEASE; PANCREAS CARCINOMA; PATIENT COMPLIANCE; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIZATION; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SKIN TOXICITY; TREATMENT OUTCOME; UROGENITAL TRACT DISEASE; VOMITING;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; PANCREATIC NEOPLASMS; TREATMENT OUTCOME;

EID: 22144444482     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.12.074     Document Type: Article

References (21)

1. A. Jemal, R.C. Tiwari, T. Murray Cancer statistics, 2004 CA Cancer J Clin 54 2004 8 29
2. H.A. Burris, M.J. Moore, J. Andersen Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer A randomized trial J Clin Oncol 15 1997 2403
3. S.J. Cohen, W.H. Pinover, J.C. Watson Pancreatic cancer Curr Treat Options Oncol 1 2000 375
4. C.G. Moertel, R.J. Reitemeier, R.G. Hahn Mitomycin-C therapy in advanced gastrointestinal cancer JAMA 204 1968 1045 1048
5. T. Buroker, P.N. Kim, C. Groppe 5-FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer A Southwest Oncology Group study Cancer 44 1979 1215 1221
6. J.E. Byfield, R. Barone, J. Mendelsohn Infusional 5-FU and X-ray therapy for nonresectable esophageal cancer Cancer 45 1980 703 708
7. B. Sischy, J.H. Remington, S.H. Sobel Treatment of carcinoma of the rectum and squamous carcinoma of the anus by combination chemotherapy, radiotherapy and operation Surg Gynecol Obstet 151 1980 369 371
8. J.B. Haslam, P.G. Cavanaugh, S.L. Stroup Radiation therapy in the treatment of irresectable adenocarcinoma of the pancreas Cancer 32 1973 1341 1345
9. D.S. Childs, C.G. Moertel, M. Holbrook Treatment of malignant neoplasms of the gastrointestinal tract with a combination of 5-fluorouracil and radiation. A randomized double-blind study Radiology 84 1965 843 848
10. N.D. Nigro, H.G. Seydel, B. Considine Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal Cancer 51 1983 1826 1829
11. R. Franklin, Z. Steiger, G. Vaishampayan Combined modality therapy for esophageal squamous cell carcinoma Cancer 51 1983 1062 1071
12. A.B. Miller, B. Hogestraeten, M. Staquet, A. Winkler Reporting results of cancer treatment Cancer 47 1981 207 214
13. M.M. Oken, R.H. Creech, D.C. Tormey Toxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 5 1982 649 655
14. E.L. Kaplan, P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 547 581
15. C.G. Moertel, S. Frytak, R.G. Hahn The Gastrointestinal Tumor Study Group Therapy of locally unresectable pancreatic carcinoma A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil Cancer 48 1981 1705 1710
16. Gastrointestinal Tumor Study Group Treatment of locally unresectable carcinoma of the pancreas Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone J Natl Cancer Inst 80 1988 751 755
17. D.J. Klaassen, J.M. MacIntyre, G.E. Catton Treatment of locally unresectable cancer of the stomach and pancreas A randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil - an Eastern Cooperative Oncology Group study J Clin Oncol 3 1985 373 378
18. J.P. Neoptolemos, D.D. Stocken, H. Friess A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer N Engl J Med 350 2004 1200 1210
19. J.D. Berlin, P. Catalano, J.P. Thomas Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma Eastern Cooperative Oncology Group Trial E2297 J Clin Oncol 20 2002 3270 3275
20. T.S. Lawrence, E.Y. Chang, T.M. Hahn Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine Int J Radiat Oncol Biol Phys 34 1996 867 872
21. C.J. McGinn, M.M. Zalupski, I. Shureiqi Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer J Clin Oncol 19 2001 4202 4208