Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease

Experimental Neurology

Volumn 236, Issue 2, 2012, Pages 249-258

  Duncan, Marilyn J ^a   Smith, J Tyler ^a   Franklin, Kathleen M ^a   Beckett, Tina L ^a,b   Murphy, M Paul ^a,b   St Clair, Daret K ^a   Donohue, Kevin D ^c   Striz, Martin ^d   O'Hara, Bruce F ^d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Activity; Period 2; Suprachiasmatic nucleus; Wheel running

Indexed keywords

AMYLOID BETA PROTEIN; NEUROPEPTIDE; PER2 PROTEIN; PRESENILIN 1;

AGING; ALZHEIMER DISEASE; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MOVEMENT; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENOTYPE; HIPPOCAMPUS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PER2 GENE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SLEEP TIME; SLEEP WAKING CYCLE; SUPRACHIASMATIC NUCLEUS; TRANSGENE; TREADMILL; WAKEFULNESS; WILD TYPE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CIRCADIAN RHYTHM; CLOCK PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCK-IN TECHNIQUES; GENOTYPE; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; MUTATION; PERIOD CIRCADIAN PROTEINS; PRESENILIN-1; SLEEP; WAKEFULNESS;

EID: 84861866541     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.05.011     Document Type: Article

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