Regioselective synthesis of pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles: Cytotoxic derivatives of pyrido[1,2-a]benzimidazolic ring system

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 11, 1998, Pages 1820-1823

  Dupuy, Marianne ^a,b   Pinguet, Frédéric ^b   Blache, Yves ^a   Chavignon, Olivier ^a   Teulade, Jean Claude ^a   Chapat, Jean Pierre ^a  

^a Laboratoire de Pharmacochimie   (France)

^b CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

Anticancer agents; Glycoprotein GP 170; Multidrug resistance; Pyrazole; Pyrazolo 4,5 g pyrido l,2 a benzimidazole; Pyrido l,2 a benzimidazole

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DOXORUBICIN; GLYCOPROTEIN P; PYRAZOLO[4,5 G]PYRIDO[1,2 A]BENZIMIDAZOLE DERIVATIVE; PYRIDO[1,2 A]BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0031730998     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1820     Document Type: Article

References (11)

1. Blache Y., Gueiffier A., Chavignon O., Teulade J.-C., Milhavet J.-C., Viols H., Chapat J.-P., Dauphin G., J. Heterocycl. Chem., 31, 161- 166 (1994); Chavignon O., Teulade J.-C., Roche D., Madesclaire M., Blache V., Gueiffier A., Chabard J.-L., Dauphin G., J. Org. Chem., 59, 6413-6418 (1994); Gueiffier A., Viols H., Blache Y., Chavignon O., Teulade J.-C., Chapat J.-P., Fauvelle F., Grassy G., Dauphin G., J. Heterocycl. Chem., 34, 765-771 (1997).
2. Blache Y., Gueiffier A., Chavignon O., Teulade J.-C., Milhavet J.-C., Viols H., Chapat J.-P., Dauphin G., J. Heterocycl. Chem., 31, 161- 166 (1994); Chavignon O., Teulade J.-C., Roche D., Madesclaire M., Blache V., Gueiffier A., Chabard J.-L., Dauphin G., J. Org. Chem., 59, 6413-6418 (1994); Gueiffier A., Viols H., Blache Y., Chavignon O., Teulade J.-C., Chapat J.-P., Fauvelle F., Grassy G., Dauphin G., J. Heterocycl. Chem., 34, 765-771 (1997).
3. Blache Y., Gueiffier A., Chavignon O., Teulade J.-C., Milhavet J.-C., Viols H., Chapat J.-P., Dauphin G., J. Heterocycl. Chem., 31, 161- 166 (1994); Chavignon O., Teulade J.-C., Roche D., Madesclaire M., Blache V., Gueiffier A., Chabard J.-L., Dauphin G., J. Org. Chem., 59, 6413-6418 (1994); Gueiffier A., Viols H., Blache Y., Chavignon O., Teulade J.-C., Chapat J.-P., Fauvelle F., Grassy G., Dauphin G., J. Heterocycl. Chem., 34, 765-771 (1997).
4. Blache Y., Sinibaldi-Troin M. E., Voldoire A., Chavignon O., Gramain J. C., Teulade J. C., Chapat J. P., J. Org. Chem., 62, 8663-8556 (1997). Blache Y., Chavignon O., Sinibaldi-Troin M. E., Gueiffier A., Teulade J. C., Troin Y., Gramain J. C., Heterocycles, 38, 1241-1246 (1994).
5. Blache Y., Sinibaldi-Troin M. E., Voldoire A., Chavignon O., Gramain J. C., Teulade J. C., Chapat J. P., J. Org. Chem., 62, 8663-8556 (1997). Blache Y., Chavignon O., Sinibaldi-Troin M. E., Gueiffier A., Teulade J. C., Troin Y., Gramain J. C., Heterocycles, 38, 1241-1246 (1994).
6. Chevillard S., Vielh P., Oncologia; 5, (1993), 3-13; Kane E. S., "Advances in Drug Research", Vol. 38, ed. by Testa B., Academic Press, London. (1996) 182-238.
7. Chevillard S., Vielh P., Oncologia; 5, (1993), 3-13; Kane E. S., "Advances in Drug Research", Vol. 38, ed. by Testa B., Academic Press, London. (1996) 182-238.
8. Badaway E., Kappe T., Eur. J. Med. Chem., 30, 327-332 (1995).
9. Blache Y., Gueiffier A., Chavignon O., Teulade J.-C., Dauphin G., Chapat J. P., Heterocycl. Commun., 2, 331-337 (1996).
10. Shuske G.-M., Tomer J.-D., J. Heterocyclic Chem., 30, 23-27 (1993).
11. Heo D. S., Park J. G., Hata K., Herbeman R. B., Whiteside T. L., Cancer Research, 30, 3681-3689 (1990).