Potential anxiolytic agents. Part 4: Novel orally-active N5-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2381-2386

  Jordan, Alfonzo D ^a   Vaidya, Anil H ^a   Rosenthal, Daniel I ^a   Dubinsky, Barry ^a   Kordik, Cheryl P ^a   Sanfilippo, Pauline J ^a   Wu, Wu Nan ^a   Reitz, Allen B ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALKYL GROUP; ANXIOLYTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BENZODIAZEPINE; METHYL GROUP; NITROGEN; PYRIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG SYNTHESIS; EVALUATION; HUMAN; IC 50; RECEPTOR AFFINITY; TRANQUILIZING ACTIVITY; ANIMAL; BRAIN CORTEX; CHEMICALLY INDUCED DISORDER; CONFLICT; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; PROTEIN BINDING; RAT; SEIZURE; SLEEP; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; BENZIMIDAZOLES; CEREBRAL CORTEX; CONFLICT (PSYCHOLOGY); HUMANS; INHIBITORY CONCENTRATION 50; MICE; PROTEIN BINDING; PYRIDINES; RATS; RECEPTORS, GABA-A; SEIZURES; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037009249     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00463-8     Document Type: Article

References (13)