메뉴 건너뛰기




Volumn 122, Issue 6, 2012, Pages 2165-2175

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CHECKPOINT KINASE 1; CISPLATIN; PROTEIN KINASE SYK; TUMOR SUPPRESSOR PROTEIN;

EID: 84861820598     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61380     Document Type: Article
Times cited : (104)

References (51)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
    • DOI 10.1053/j.gastro.2007.04.061, PII S0016508507007998
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132(7):2557-2576. (Pubitemid 46890874)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 58849143425 scopus 로고    scopus 로고
    • The epidemiology of hepatocellular cancer: From the perspectives of public health problem to tumor biology
    • Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol. 2009;44 suppl 19:96-101.
    • (2009) J Gastroenterol , vol.44 , Issue.SUPPL. 19 , pp. 96-101
    • Caldwell, S.1    Park, S.H.2
  • 4
    • 33646567160 scopus 로고    scopus 로고
    • Systematic review: Evidence-based management of hepatocellular carcinoma - An updated analysis of randomized controlled trials
    • DOI 10.1111/j.1365-2036.2006.02932.x
    • Lopez PM, Villanueva A, Llovet JM. Systematic review: evidence-based management of hepatocellular carcinoma--an updated analysis of randomized controlled trials. Aliment Pharmacol Ther. 2006;23(11):1535-1547. (Pubitemid 43727460)
    • (2006) Alimentary Pharmacology and Therapeutics , vol.23 , Issue.11 , pp. 1535-1547
    • Lopez, P.M.1    Villanueva, A.2    Llovet, J.M.3
  • 6
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359(4):378-390.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1
  • 7
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10(1):25-34.
    • (2009) Lancet Oncol , vol.10 , Issue.1 , pp. 25-34
    • Cheng, A.L.1
  • 8
    • 0034680108 scopus 로고    scopus 로고
    • The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells
    • Coopman PJ, et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature. 2000;406(6797):742-747.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 742-747
    • Coopman, P.J.1
  • 9
    • 33746671852 scopus 로고    scopus 로고
    • The Syk tyrosine kinase: A new negative regulator in tumor growth and progression
    • DOI 10.1016/j.canlet.2005.11.004, PII S0304383505009869
    • Coopman PJ, Mueller SC. The Syk tyrosine kinase: a new negative regulator in tumor growth and progression. Cancer Lett. 2006;241(2):159-173. (Pubitemid 44163045)
    • (2006) Cancer Letters , vol.241 , Issue.2 , pp. 159-173
    • Coopman, P.J.1    Mueller, S.C.2
  • 11
    • 70449348605 scopus 로고    scopus 로고
    • Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo
    • Sung YM, et al. Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo. PLoS One. 2009;4(10):e7445.
    • (2009) PLoS One , vol.4 , Issue.10
    • Sung, Y.M.1
  • 12
    • 66349132292 scopus 로고    scopus 로고
    • Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells
    • Zhang X, Shrikhande U, Alicie BM, Zhou Q, Geahlen RL. Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol Cancer Res. 2009;7(5):634-644.
    • (2009) Mol Cancer Res , vol.7 , Issue.5 , pp. 634-644
    • Zhang, X.1    Shrikhande, U.2    Alicie, B.M.3    Zhou, Q.4    Geahlen, R.L.5
  • 13
    • 33845303143 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of Spleen tyrosine kinase gene in human hepatocellular carcinoma
    • DOI 10.1158/1078-0432.CCR-06-0921
    • Yuan Y, et al. Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res. 2006;12(22):6687-6695. (Pubitemid 44876836)
    • (2006) Clinical Cancer Research , vol.12 , Issue.22 , pp. 6687-6695
    • Yuan, Y.1    Wang, J.2    Li, J.3    Wang, L.4    Li, M.5    Yang, Z.6    Zhang, C.7    Jia, L.D.8
  • 14
    • 33646119178 scopus 로고    scopus 로고
    • Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer
    • Nakashima H, et al. Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer. Cancer Lett. 2006;236(1):89-94.
    • (2006) Cancer Lett , vol.236 , Issue.1 , pp. 89-94
    • Nakashima, H.1
  • 15
    • 73549116304 scopus 로고    scopus 로고
    • Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion
    • Layton T, Stalens C, Gunderson F, Goodison S, Silletti S. Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. Am J Pathol. 2009;175(6):2625-2636.
    • (2009) Am J Pathol , vol.175 , Issue.6 , pp. 2625-2636
    • Layton, T.1    Stalens, C.2    Gunderson, F.3    Goodison, S.4    Silletti, S.5
  • 16
    • 0043136678 scopus 로고    scopus 로고
    • Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer
    • Wang L, et al. Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer. Cancer Res. 2003;63(15):4724-4730. (Pubitemid 36951053)
    • (2003) Cancer Research , vol.63 , Issue.15 , pp. 4724-4730
    • Wang, L.1    Duke, L.2    Zhang, P.S.3    Arlinghaus, R.B.4    Symmans, W.F.5    Sahin, A.6    Mendez, R.7    Dai, J.L.8
  • 17
    • 64249153223 scopus 로고    scopus 로고
    • Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma
    • Ogane S, Onda T, Takano N, Yajima T, Uchiyama T, Shibahara T. Spleen tyrosine kinase as a novel candidate tumor suppressor gene for human oral squamous cell carcinoma. Int J Cancer. 2009;124(11):2651-2657.
    • (2009) Int J Cancer , vol.124 , Issue.11 , pp. 2651-2657
    • Ogane, S.1    Onda, T.2    Takano, N.3    Yajima, T.4    Uchiyama, T.5    Shibahara, T.6
  • 18
    • 45149084830 scopus 로고    scopus 로고
    • TULA proteins regulate activity of the protein tyrosine kinase Syk
    • DOI 10.1002/jcb.21678
    • Agrawal R, Carpino N, Tsygankov A. TULA proteins regulate activity of the protein tyrosine kinase Syk. J Cell Biochem. 2008;104(3):953-964. (Pubitemid 351830843)
    • (2008) Journal of Cellular Biochemistry , vol.104 , Issue.3 , pp. 953-964
    • Agrawal, R.1    Carpino, N.2    Tsygankov, A.3
  • 19
    • 77957758524 scopus 로고    scopus 로고
    • Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate
    • Chen X, et al. Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem. 2010;285(41):31268-31276.
    • (2010) J Biol Chem , vol.285 , Issue.41 , pp. 31268-31276
    • Chen, X.1
  • 20
    • 79958812227 scopus 로고    scopus 로고
    • Alternative splicing of SYK regulates mitosis and cell survival
    • Prinos P, et al. Alternative splicing of SYK regulates mitosis and cell survival. Nat Struct Mol Biol. 2011;18(6):673-679.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.6 , pp. 673-679
    • Prinos, P.1
  • 21
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • DOI 10.1128/MCB.21.13.4129-4139.2001
    • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001;21(13):4129-4139. (Pubitemid 32565295)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.13 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 23
    • 74549189337 scopus 로고    scopus 로고
    • New insights into checkpoint kinase 1 in the DNA damage response signaling network
    • Dai Y, Grant S. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res. 2010;16(2):376-383.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 376-383
    • Dai, Y.1    Grant, S.2
  • 24
    • 74949120032 scopus 로고    scopus 로고
    • Targeting the checkpoint kinase Chk1 in cancer therapy
    • Merry C, Fu K, Wang J, Yeh IJ, Zhang Y. Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle. 2010;9(2):279-283.
    • (2010) Cell Cycle , vol.9 , Issue.2 , pp. 279-283
    • Merry, C.1    Fu, K.2    Wang, J.3    Yeh, I.J.4    Zhang, Y.5
  • 25
    • 79955686677 scopus 로고    scopus 로고
    • CHK1 inhibitors in combination chemotherapy: Thinking beyond the cell cycle
    • Dent P, Tang Y, Yacoub A, Dai Y, Fisher PB, Grant S. CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle. Mol Interv. 2011;11(2):133-140.
    • (2011) Mol Interv , vol.11 , Issue.2 , pp. 133-140
    • Dent, P.1    Tang, Y.2    Yacoub, A.3    Dai, Y.4    Fisher, P.B.5    Grant, S.6
  • 26
    • 0033970743 scopus 로고    scopus 로고
    • Substrate specificity determinants of the checkpoint protein kinase Chk1
    • DOI 10.1016/S0014-5793(99)01763-9, PII S0014579399017639
    • Hutchins JR, Hughes M, Clarke PR. Substrate specificity determinants of the checkpoint protein kinase Chk1. FEBS Lett. 2000;466(1):91-95. (Pubitemid 30050690)
    • (2000) FEBS Letters , vol.466 , Issue.1 , pp. 91-95
    • Hutchins, J.R.A.1    Hughes, M.2    Clarke, P.R.3
  • 28
    • 77956405785 scopus 로고    scopus 로고
    • Chk1 inhibitor Go6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo
    • Feng Z, Xu S, Liu M, Zeng YX, Kang T. Chk1 inhibitor Go6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo. Cancer Lett. 2010;297(2):190-197.
    • (2010) Cancer Lett , vol.297 , Issue.2 , pp. 190-197
    • Feng, Z.1    Xu, S.2    Liu, M.3    Zeng, Y.X.4    Kang, T.5
  • 29
    • 66149162000 scopus 로고    scopus 로고
    • A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint
    • Beckerman R, et al. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev. 2009;23(11):1364-1377.
    • (2009) Genes Dev , vol.23 , Issue.11 , pp. 1364-1377
    • Beckerman, R.1
  • 30
    • 33749626550 scopus 로고    scopus 로고
    • Phosphorylation of Chk1 by ATR is antagonized by a chk1-regulated protein phosphatase 2A circuit
    • DOI 10.1128/MCB.00447-06
    • Leung-Pineda V, Ryan CE, Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol. 2006;26(20):7529-7538. (Pubitemid 44547703)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.20 , pp. 7529-7538
    • Van Leung-Pineda1    Ryan, C.E.2    Piwnica-Worms, H.3
  • 32
    • 28544449211 scopus 로고    scopus 로고
    • Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression
    • DOI 10.1158/0008-5472.CAN-05-2231
    • Wang L, Devarajan E, He J, Reddy SP, Dai JL. Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression. Cancer Res. 2005;65(22):10289-10297. (Pubitemid 41743721)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10289-10297
    • Lei, W.1    Devarajan, E.2    Jin, H.3    Reddy, S.P.4    Le, D.J.5
  • 33
    • 77958480403 scopus 로고    scopus 로고
    • Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
    • Niida H, et al. Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J. 2010;29(20):3558-3570.
    • (2010) EMBO J , vol.29 , Issue.20 , pp. 3558-3570
    • Niida, H.1
  • 37
    • 22844436238 scopus 로고    scopus 로고
    • Chk1 is essential for tumor cell viability following activation of the replication checkpoint
    • Cho SH, Toouli CD, Fujii GH, Crain C, Parry D. Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle. 2005;4(1):131-139. (Pubitemid 41038942)
    • (2005) Cell Cycle , vol.4 , Issue.1 , pp. 131-139
    • Cho, S.H.1    Toouli, C.D.2    Fujii, G.H.3    Crain, C.4    Parry, D.5
  • 38
    • 59449085778 scopus 로고    scopus 로고
    • Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
    • Lundgren K, Holm K, Nordenskjold B, Borg A, Landberg G. Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. Breast Cancer Res. 2008;10(5):R81.
    • (2008) Breast Cancer Res , vol.10 , Issue.5
    • Lundgren, K.1    Holm, K.2    Nordenskjold, B.3    Borg, A.4    Landberg, G.5
  • 39
    • 0034525791 scopus 로고    scopus 로고
    • Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization
    • DOI 10.1309/BMTT-JBPD-D13H-1UVD
    • Wilkens L, Bredt M, Flemming P, Kubicka S, Klempnauer J, Kreipe H. Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. Am J Clin Pathol. 2000;114(6):867-874. (Pubitemid 33051886)
    • (2000) American Journal of Clinical Pathology , vol.114 , Issue.6 , pp. 867-874
    • Wilkens, L.1    Bredt, M.2    Flemming, P.3    Kubicka, S.4    Klempnauer, J.5    Kreipe, H.6
  • 40
    • 84984562908 scopus 로고    scopus 로고
    • Chromosomal analysis of hepatic adenoma and focal nodular hyperplasia by comparative genomic hybridization
    • DOI 10.1002/gcc.10103
    • Chen YJ, Chen PJ, Lee MC, Yeh SH, Hsu MT, Lin CH. Chromosomal analysis of hepatic adenoma and focal nodular hyperplasia by comparative genomic hybridization. Genes Chromosomes Cancer. 2002;35(2):138-143. (Pubitemid 34919970)
    • (2002) Genes Chromosomes and Cancer , vol.35 , Issue.2 , pp. 138-143
    • Chen, Y.-J.1    Chen, P.-J.2    Lee, M.-C.3    Yeh, S.-H.4    Hsu, M.-T.5    Lin, C.-H.6
  • 41
    • 70350222210 scopus 로고    scopus 로고
    • Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair
    • Bolderson E, Richard DJ, Zhou BB, Khanna KK. Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin Cancer Res. 2009;15(20):6314-6320.
    • (2009) Clin Cancer Res , vol.15 , Issue.20 , pp. 6314-6320
    • Bolderson, E.1    Richard, D.J.2    Zhou, B.B.3    Khanna, K.K.4
  • 42
    • 79651470785 scopus 로고    scopus 로고
    • Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
    • Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med. 2011;17(2):88-96.
    • (2011) Trends Mol Med , vol.17 , Issue.2 , pp. 88-96
    • Ma, C.X.1    Janetka, J.W.2    Piwnica-Worms, H.3
  • 43
    • 34547094373 scopus 로고    scopus 로고
    • UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: A study of the Princess Margaret Hospital Phase II consortium
    • DOI 10.1016/j.ygyno.2007.02.018, PII S0090825807001461
    • Welch S, et al. UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium. Gynecol Oncol. 2007;106(2):305-310. (Pubitemid 47096653)
    • (2007) Gynecologic Oncology , vol.106 , Issue.2 , pp. 305-310
    • Welch, S.1    Hirte, H.W.2    Carey, M.S.3    Hotte, S.J.4    Tsao, M.-S.5    Brown, S.6    Pond, G.R.7    Dancey, J.E.8    Oza, A.M.9
  • 45
    • 79959604565 scopus 로고    scopus 로고
    • A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
    • Fracasso PM, et al. A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2011;67(6):1225-1237.
    • (2011) Cancer Chemother Pharmacol , vol.67 , Issue.6 , pp. 1225-1237
    • Fracasso, P.M.1
  • 47
    • 78650215702 scopus 로고    scopus 로고
    • Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
    • Al-Ejeh F, Kumar R, Wiegmans A, Lakhani SR, Brown MP, Khanna KK. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene. 2010;29(46):6085-6098.
    • (2010) Oncogene , vol.29 , Issue.46 , pp. 6085-6098
    • Al-Ejeh, F.1    Kumar, R.2    Wiegmans, A.3    Lakhani, S.R.4    Brown, M.P.5    Khanna, K.K.6
  • 48
    • 78650208984 scopus 로고    scopus 로고
    • Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents
    • Zenvirt S, Kravchenko-Balasha N, Levitzki A. Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents. Oncogene. 2010;29(46):6149-6159.
    • (2010) Oncogene , vol.29 , Issue.46 , pp. 6149-6159
    • Zenvirt, S.1    Kravchenko-Balasha, N.2    Levitzki, A.3
  • 49
    • 37349094929 scopus 로고    scopus 로고
    • GSK-3beta Targets Cdc25A for Ubiquitin-Mediated Proteolysis, and GSK-3beta Inactivation Correlates with Cdc25A Overproduction in Human Cancers
    • DOI 10.1016/j.ccr.2007.12.002, PII S1535610807003716
    • Kang T, et al. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008;13(1):36-47. (Pubitemid 350309739)
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 36-47
    • Kang, T.1    Wei, Y.2    Honaker, Y.3    Yamaguchi, H.4    Appella, E.5    Hung, M.-C.6    Piwnica-Worms, H.7
  • 50
    • 77951192102 scopus 로고    scopus 로고
    • Stem-like cancer cells are inducible by increasing genomic instability in cancer cells
    • Liang Y, et al. Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. J Biol Chem. 2010;285(7):4931-4940.
    • (2010) J Biol Chem , vol.285 , Issue.7 , pp. 4931-4940
    • Liang, Y.1
  • 51
    • 77950212486 scopus 로고    scopus 로고
    • Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: Inactivation of the NF-kappaB pathway and generation of reactive oxygen species
    • Jin Y, et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010;70(6):2516-2527.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2516-2527
    • Jin, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.