5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice

Pharmacology Biochemistry and Behavior

Volumn 102, Issue 2, 2012, Pages 344-348

  Ulugol, Ahmet ^a   Oltulu, Cagatay ^a   Gunduz, Ozgur ^a   Citak, Cihad ^a   Carrara, Roberto ^b   Shaqaqi, Mohammad Reza ^c   Sanchez, Alicia Mansilla ^d   Dogrul, Ahmet ^e  

^a TRAKYA UNIVERSITY   (Turkey)

^b UNIVERSITY OF PAVIA   (Italy)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d University of Pompeu Fabra   (Spain)

^e GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

5 HT7 receptors; Diabetes; Serotonin; Thermal hyperalgesia; Thermal hypoalgesia

Indexed keywords

3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; AS 19; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HOT PLATE TEST; HYPERALGESIA; HYPOALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST; THERMAL HYPERALGESIA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; HOT TEMPERATURE; HYPERALGESIA; MICE; MICE, INBRED BALB C; PIPERIDINES; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STREPTOZOCIN; SULFONAMIDES;

ANIMALIA; MUS;

EID: 84861815482     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.05.006     Document Type: Article

References (38)

1. Aicher SA, Hermes SM, Whittier KL, Hegarty DM. Descending projections from the rostral ventromedial medulla (RVM) to trigeminal and spinal dorsal horns are morphologically and neurochemically distinct. J Chem Neuroanat 2011. http://dx.doi.org/10.1016/j.jchemneu.2011.11.002.
2. Andrews N, O'neill M. It might be a big family but the pain remains - last chance saloon for selective 5-HT receptor ligands? Curr Opin Pharmacol 2011;11:39-44.
3. Bardin L. The complex role of serotonin and 5-HT receptors in chronic pain. Behav Pharmacol 2011;22:390-404.
4. Brenchat A, Romero L, Garcia M, Pujol M, Burgueno J, Torrens A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain 2009;141:239-47.
5. Brenchat A, Nadal X, Romero L, Ovalle S, Muro A, Sanchez-Arroyos R, et al. Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal sensitivity. Pain 2010;149:483-94.
6. Brenchat A, Zamanillo D, Hamon M, Romero L, Vela JM. Role of peripheral versus spinal 5-HT7 receptors in the modulation of pain undersensitizing conditions. Eur J Pain 2012;16:72-81.
7. Chen X, Levine JD. Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat. Neuroscience 2001a;102:185-92.
8. Chen X, Levine JD. Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat. Neuroscience 2001b;121:1007-15.
9. Chen SR, Samoriski G, Pan HL. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology 2009;57:121-6.
10. Colleoni M, Sacerdote P. Murine models of human neuropathic pain. Biochim Biophys Acta 2010;1802:924-33.
11. Courteix C, Eschalier A, Lavarenne J. Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 1993;53:81-8.
12. Davidson EP, Coppey LJ, Dake B, Yorek MA. Treatment of streptozocin-induced diabetic rats with alogliptin: effect on vascular and neural complications. Exp Diabetes Res 2011. http://dx.doi.org/10.1155/2011/ 810469.
13. Dogrul A, Seyrek M. Systemic morphine produce antinociception mediated by spinal 5- HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord. Br J Pharmacol 2006;149:498-505.
14. Dogrul A, SeyrekM, Yalcin B, Ulugol A. Involvement of descending serotonergic and noradrenergic pathways in cannabinoid CB1 receptor-mediated antinociception. Prog Neuropsychopharmacol Biol Psychiatry 2012a. http://dx.doi.org/10.1016/j.pnpbp.2012.01.007.
15. Dogrul A, Ossipov MH, Porreca F. Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Res 2009;1280:52-9.
16. Dogrul A, Seyrek M, Akgul EO, Cayci T, Kahraman S, Bolay H. Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT(7) receptors. Eur J Pharmacol 2012b;677:93-101.
17. Doly S, Fischer J, Brisorgueil MJ, Verge D, Conrath M. Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal horn spinal cord: immunocytochemical evidence. J Comp Neurol 2005;26:256-69.
18. Gunduz O, Oltulu C, Buldum D, Guven R, Ulugol A. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats. Neurosci Lett 2011;491:23-5.
19. Hedlund PB. The 5-HT7 receptor and disorders of the nervous system: an overview. Psychopharmacology 2009;206:345-54.
20. Kamei J, Ohsawa M, Miyata S, Endo K, Hayakawa H. Effects of cytidine 5′-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice. Eur J Pharmacol 2008;598:32-6.
21. Kapur D. Neuropathic pain and diabetes. Diabetes Metab Res Rev 2003;19:S9-15.
22. Karadag HC, Ulugol A, Tamer M, Ipci Y, Dokmeci I. Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats. Neurosci Lett 2003;339:88-90.
23. Leopoldo M, Lacivita E, Berardi F, Perrone R, Hedlund PB. Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther 2011;129:120-48.
24. Liu FY, Qu XX, Ding X, Cai J, Jiang H, Wan Y, et al. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Res 2010;1330:45-60.
25. Marks DM, Shah MJ, Patkar AA, Masand PS, Park GY, Pae CU. Serotonin-norepinefrine reuptake inhibitors for pain control: premise and promise. Curr Neuropharmacol 2009;7:331-6.
26. Millan MJ. Descending control of pain. Prog Neurobiol 2002;66:355-474.
27. Morgado C, Silva L, Pereira-Terra P, Tavares I. Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: the preventive action of IGF1. Neurobiol Dis 2011;43:275-84.
28. Obrosova IG. Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics 2009;6:638-47.
29. Ohsawa M, Miyata S, Carlsson A, Kamei J. Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice. Eur J Pharmacol 2008;588:213-6.
30. Quattrini C, Tesfaye S. Understanding the impact of painful diabetic neuropathy. Diabetes Metab Res Rev 2003;19:S2-8.
31. Rocha-Gonzalez HI, Meneses A, Carlton SM, Granados-Soto V. Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test. Pain 2005;117:182-92.
32. Seyrek M, Kahraman S, Deveci MS, Yesilyurt O, Dogrul A. Systemic cannabinoids produce CB1-mediated antinociception by activation of descending serotonergic pathways that act upon spinal 5-HT7 and 5-HT2A receptors. Eur J Pharmacol 2010;649:183-94.
33. Tesfaye S. Advances in the management of diabetic peripheral neuropathy. Curr Opin Support Palliat Care 2009;3:136-43.
34. Tesfaye S, Selvarajah D. Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy. Diabetes Metab Res Rev 2012. http://dx.doi.org/10.1002/dmrr.2239.
35. Ulugol A, Karadag HC, Tamer M, Firat Z, Aslantas A, Dokmeci I. Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozocin-induced diabetic rats. Neurosci Lett 2002;328:129-32.
36. Ulugol A, Karadag HC, Ipci Y, Tamer M, Dokmeci I. The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats. Neurosci Lett 2004;371:167-70.
37. Yanarates O, Dogrul A, Yildirim V, Sahin A, Sizlan A, Seyrek M, et al. Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, o-desmethyltramadol, via activation of descending serotonergic pathways. Anesthesiology 2010;112:696-710.
38. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10.