Gram-negative and gram-positive bacterial infections give rise to a different metabolic response in a mouse model

Journal of Proteome Research

Volumn 11, Issue 6, 2012, Pages 3231-3245

  Hoerr, Verena ^a,c   Zbytnuik, Lori ^b   Leger, Caroline ^b   Tam, Patrick P C ^b   Kubes, Paul ^b   Vogel, Hans J ^a  

^a Department of Biological Sciences   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

1H NMR spectroscopy; bacteria secreted metabolites; cytokine responses; Gram negative and Gram positive bacterial infections; host response; knockout mice; metabolic responses; metabolomics; multivariate data analysis; physiological responses

Indexed keywords

2 HYDROXYBUTYRATE DEHYDROGENASE; 3 HYDROXYBUTYRIC ACID; ACETONE; ALCOHOL; CREATINE; GRANULOCYTE COLONY STIMULATING FACTOR; HIPPURIC ACID; HISTIDINE; INTERLEUKIN 10; INTERLEUKIN 6; ISOLEUCINE; LEUCINE; LIPOPOLYSACCHARIDE; LYSINE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; ORNITHINE; PHENYLALANINE; RANTES; TAURINE; THREONINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; VALINE; CYTOKINE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPETITE DISORDER; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CONTROLLED STUDY; CYTOKINE RESPONSE; DIARRHEA; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME ACTIVITY; ESCHERICHIA COLI INFECTION; GLYCOLYSIS; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IN VIVO STUDY; LEUKOCYTE COUNT; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS INFECTION; STAPHYLOCOCCUS INFECTION; WEIGHT REDUCTION; ANIMAL; BLOOD; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; ESCHERICHIA COLI; EXTRACELLULAR FLUID; GENETICS; IMMUNOLOGY; INTRACELLULAR FLUID; KNOCKOUT MOUSE; MALE; METABOLISM; METABOLOME; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MUS; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; EXTRACELLULAR FLUID; HOST-PATHOGEN INTERACTIONS; INTRACELLULAR FLUID; LIPOPOLYSACCHARIDES; MALE; METABOLOME; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMOCOCCAL INFECTIONS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; VIRULENCE FACTORS;

EID: 84861797417     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr201274r     Document Type: Article

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