Fibroblasts, myofibroblasts, and fibrosis: Fact, fiction, and the future

Journal of Cardiovascular Pharmacology

Volumn 57, Issue 4, 2011, Pages 373-375

  Duffy, Heather S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

arrhythmia; cell coupling; Heart

Indexed keywords

CONNEXIN 45; VASCULOTROPIN;

BLOOD FLOW; CELL FUNCTION; CELL INTERACTION; CELL STRESS; ELECTRON MICROSCOPE; FIBROBLAST; FIBROSIS; GAP JUNCTION; HEART FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE TACHYCARDIA; HUMAN; MOLECULAR INTERACTION; MYOFIBROBLAST; PRIORITY JOURNAL; REVIEW;

FIBROBLASTS; FIBROSIS; HUMANS; MYOCARDIUM; MYOCYTES, CARDIAC; MYOFIBROBLASTS;

EID: 79955039546     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182155a38     Document Type: Review

References (19)

1. Miragoli M, Gaudesius G, Rohr S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ Res. 2006;98:801-810.
2. Goshima K. Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture. Exp Cell Res. 1969;58:420-426.
3. Hyde A, Blondel B, Matter A, et al. Homo-andheterocellular junctions in cell cultures: an electrophysiological and morphological study. Prog Brain Res. 1969;31:283-311.
4. Goshima K. Formation of nexuses and electrotonic transmission between myocardial and FL cells in monolayer culture. Exp Cell Res. 1970;63:124-130.
5. Rook MB, Jongsma HJ, de Jonge B. Single channel currents of homo-and heterologous gap junctions between cardiac fibroblasts and myocytes. Pflugers Arch. 1989;414:95-98. (Pubitemid 19140449)
6. Gaudesius G, Miragoli M, Thomas SP, et al. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ Res. 2003;93:421-428. (Pubitemid 37100007)
7. Sachse FB, Moreno AP, Abildskov JA. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng. 2008; 36:41-56. (Pubitemid 50002703)
8. Xie Y, Garfinkel A, Camelliti P, et al. Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: a computa-tional study Heart Rhythm. 2009;6:1641-1649.
9. Maleckar MM, Greenstein JL, Giles WR, et al. Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophys J. 2009;97:2179-2190.
10. Xie Y, Garfinkel A, Camelliti P, et al. Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: a computa-tional study Heart Rhythm. 2009;6:1641-1649.
11. Sachse FB, Moreno AP, Abildskov JA. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng. 2008; 36:41-56. (Pubitemid 50002703)
12. Camelliti P, Green CR, LeGrice I, et al. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res. 2004;94:828-835. (Pubitemid 38451745)
13. Baum JR, Duffy HS. Fibroblasts and myofibroblasts: what are we talking about. J Cardiovasc Pharm. 2011;57:376-379.
14. Vasquez C, Benamer N, Morley G The cardiac fibroblast: functional and electrophysiological considerations in healthy and diseased hearts. J Cardiovasc Pharm. 2011;57:380-388.
15. Rohr S. Cardiac fibroblasts in cell culture systems: myofibroblasts all along? J Cardiovasc Pharm. 2011;57:389-399.
16. Ottaviano FG, Yee KO. Communication signals between cardiac fibro-blasts and cardiac myocytes. J Cardiovasc Pharm. In press.
17. De Jong S, van Veen TAB, de Bakker JMT, et al. Biomarkers ofmyocardial fibrosis. J Cardiovasc Pharm. In press.
18. Tan AY, Zimetbaum P. Atrial fibrillation and atrial fibrosis. J Cardiovasc Pharm. In press.
19. De Jong S, van Veen TAB, van Rijen HVM, et al. Fibrosis and cardiac arrhythmias. J Cardiovasc Pharm. In press.