Nanoparticle shape improves delivery: Rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles

Advanced Materials

Volumn 24, Issue 28, 2012, Pages 3823-3830

  Loverde, Sharon M ^a   Klein, Michael L ^b   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Temple University   (United States)

Author keywords

coarse grain molecular dynamics; drug delivery; partition coefficient paclitaxel; thermodynamic integration

Indexed keywords

ANTICANCER DRUG; BLOCK COPOLYMER MICELLES; COARSE GRAINS; MOLECULAR DYNAMICS SIMULATIONS; NANOCARRIERS; NANOPARTICLE SHAPE; PACLITAXEL; SHAPE-DEPENDENT EFFECTS; SPHERICAL MICELLES; THERMODYNAMIC INTEGRATION;

BIOLOGICAL MATERIALS; BLOCK COPOLYMERS; COMPUTER SIMULATION; DRUG DELIVERY; MICELLES; NANOPARTICLES; TUMORS;

MOLECULAR DYNAMICS;

ANTINEOPLASTIC AGENT; BIOMATERIAL; DRUG CARRIER; ETHYLENE OXIDE; LACTONE; NANOPARTICLE; PACLITAXEL; PLC(20) B PEO(44); PLC(20)-B-PEO(44);

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MATERIALS TESTING; MICELLE; MOLECULAR DYNAMICS; NANOTECHNOLOGY; PARTICLE SIZE; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; ETHYLENE OXIDE; HUMANS; LACTONES; MATERIALS TESTING; MICELLES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NANOPARTICLES; NANOTECHNOLOGY; PACLITAXEL; PARTICLE SIZE;

EID: 84861775179     PISSN: 09359648     EISSN: 15214095     Source Type: Journal    
DOI: 10.1002/adma.201103192     Document Type: Article

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