Regulation of blood viscosity in disease prevention and treatment

Chinese Science Bulletin

Volumn 57, Issue 16, 2012, Pages 1946-1952

  Chen, Gan ^a   Zhao, Lian ^a   Liu, YaoWen ^a   Liao, FuLong ^b   Han, Dong ^b   Zhou, Hong ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

blood viscosity; cardio cerebrovascular diseases; diabetes mellitus; endothelial dysfunction; hemorrhagic shock

Indexed keywords

EID: 84861745824     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-012-5165-4     Document Type: Review

References (101)

1. Dintenfass L. Rheology of Blood in Diagnostic and Preventive Medicine: An Introduction to Clinical Haemorheology. London, Boston: Butterworths, 1976. 396.
2. Liao F L. Clinical Hemorheology (in Chinese). Tianjin: Tianjin Science & Technology Translation & Publishing Co, 1987. 210.
3. Chen W J. Hemorheology (in Chinese). Tianjin: Tianjin Science and Technology Press, 1987. 322.
4. Salazar Vazquez B Y, Martini J, Chavez Negrete A, et al. Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence. Clin Hemorheol Microcirc, 2010, 44: 75-85.
5. Jeong S K, Cho Y I, Duey M, et al. Cardiovascular risks of anemia correction with erythrocyte stimulating agents: Should blood viscosity be monitored for risk assessment? Cardiovasc Drugs Ther, 2010, 24: 151-160.
6. Allen M T, Patterson S M. Hemoconcentration and stress: A review of physiological mechanisms and relevance for cardiovascular disease risk. Biol Psychol, 1995, 41: 1-27.
7. De Simone G, Devereux R, Chien S, et al. Relation of blood viscosity to demographic and physiologic variables and to cardiovascular risk factors in apparently normal adults. Circulation, 1990, 81: 107-117.
8. Pehlivanoglu B, Dikmenoglu N, Balkanci D Z. Effect of stress on erythrocyte deformability, influence of gender and menstrual cycle. Clin Hemorheol Microcirc, 2007, 37: 301-308.
9. Boer D D, Ring C, Curlett A C, et al. Mental stress-induced hemoconcentration and its recovery: A controlled study of time course and mechanisms. Psychophysiology, 2007, 44: 161-169.
10. Galduroz J C F, Antunes H K, Santos R F. Gender- and age-related variations in blood viscosity in normal volunteers: A study of the effects of extract of Allium sativum and Ginkgo biloba. Phytomedicine, 2007, 14: 447-451.
11. Gonez C, Donayre M, Villena A, et al. Hematocrit levels in children at sea level and at high altitude: Effect of adrenal androgens. Hum Biol, 1993, 65: 49-57.
12. Temte J L. Elevation of serum cholesterol at high altitude and its relationship to hematocrit. Wilderness Environ Med, 1996, 7: 216-224.
13. Bassuni W, Asindi A A, Mustafa F S, et al. Hemoglobin and hematocrit values of Saudi newborns in the high altitude of Abha, Saudi Arabia. Ann Saudi Med, 1996, 16: 527-529.
14. Erzurum S C, Ghosh S, Janocha A J, et al. Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci USA, 2007, 104: 17593-17598.
15. Cheng S K, Yu J Y, Si B H, et al. Study on the relationship of high hematocrit with changes of the blood viscosity during in the environment of altitude hypoxia (in Chinese). Chin J Appl Physiol, 2001, 17: 231-234.
16. Martini J, Carpentier B, Chávez Negrete A, et al. Beneficial effects due to increasing blood and plasma viscosity. Clin Hemorheol Microcirc, 2006, 35: 51-57.
17. Faeh D, Gutzwiller F, Bopp M, et al. Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland. Circulation, 2009, 120: 495-501.
18. De Simone G, Devereux R B, Chinali M, et al. Association of blood pressure with blood viscosity in american indians: The Strong Heart Study. Hypertension, 2005, 45: 625-630.
19. Salazar Vázquez B Y, Salazar Vázquez M A, Guajardo Jaquez M, et al. Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals. Clin Hemorheol Microcirc, 2010, 44: 55-61.
20. Salazar Vázquez B Y, Vazquez M A, Intaglietta M, et al. Hematocrit and mean arterial blood pressure in pre- and postmenopause women. Vasc Health Risk Manag, 2009, 5: 483-488.
21. Salazar Vázquez B Y, Intaglietta M, Rodríguez-Morán M, et al. Blood pressure and hematocrit in diabetes and the role of endothelial responses in the variability of blood viscosity. Diabetes Care, 2006, 29: 1523-1528.
22. Loscalzo J. Oxidative stress in endothelial cell dysfunction and thrombosis. Pathophysiol Haemost Thromb, 2002, 32: 359-360.
23. Lowe G D, Lee A J, Rumley A, et al. Blood viscosity and risk of cardiovascular events: The Edinburgh Artery Study. Br J Haematol, 1997, 96: 168-173.
24. Lee A J, Mowbray P I, Lowe G D, et al. Blood viscosity and elevated carotid intima-media thickness in men and women: The Edinburgh Artery Study. Circulation, 1998, 97: 1467-1473.
25. Cecchi E, Marcucci R, Poli D, et al. Hyperviscosity as a possible risk factor for cerebral ischemic complications in atrial fibrillation patients. Am J Cardiol, 2006, 97: 1745-1748.
26. Woodward M, Rumley A, Tunstall-Pedoe H, et al. Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland. Brit J Haematol, 2003, 122: 645-650.
27. Skretteberg P T, Bodegard J, Kjeldsen S E, et al. Interaction between inflammation and blood viscosity predicts cardiovascular mortality. Scand Cardiovasc J, 2010, 44: 107-112.
28. Cecchi E, Liotta A A, Gori A M, et al. Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Int J Cardiol, 2009, 134: 189-194.
29. Malinova L I, Dovgalevsky P Y. Hemorheological system in coronary heart disease patients: Prognostic value. Cardiovasc Ther Prev, 2007, 6: 19-24.
30. Ciuffetti G, Schillaci G, Lombardini R, et al. Prognostic impact of low-shear whole blood viscosity in hypertensive men. Eur J Clin Invest, 2005, 35: 93-98.
31. Cohen J D. Overview of physiology, vascular biology, and mechanisms of hypertension. J Manag Care Pharm, 2007, 13: 6-8.
32. Baron A D, Clark M G. Role of blood flow in the regulation of muscle glucose uptake. Annu Rev Nutr, 1997, 17: 487-499.
33. Hoieggen A, Fossum E, Moan A, et al. Whole-blood viscosity and the insulin-resistance syndrome. J Hypertens, 1998, 16: 203-210.
34. Ercan M, Konukoglu D. Role of plasma viscosity and plasma homocysteine level on hyperinsulinemic obese female subjects. Clin Hemorheol Microcirc, 2008, 38: 227-234.
35. Richards R S, Nwose E U. Blood viscosity at different stages of diabetes pathogenesis. Br J Biomed Sci, 2010, 67: 67-70.
36. Tamariz L J, Young J H, Pankow J S, et al. Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: The atherosclerosis risk in communities (ARIC) study. Am J Epidemiol, 2008, 168: 1153-1160.
37. Lowe G D, Lowe J M, Drummond M M, et al. Blood viscosity in young male diabetics with and without retinopathy. Diabetologia, 1980, 18: 359-363.
38. Turczynski B, Michalska-Malecka K, Slowinska L, et al. Correlations between the severity of retinopathy in diabetic patients and whole blood and plasma viscosity. Clin Hemorheol Microcirc, 2003, 29: 129-137.
39. Irace C, Scarinci F, Scorcia V, et al. Association among low whole blood viscosity, haematocrit, haemoglobin and diabetic retinopathy in subjects with type 2 diabetes. Br J Ophthalmol, 2011, 95: 94-98.
40. Schut N H, van Arkel E C, Hardeman M R, et al. Blood and plasma viscosity in diabetes: Possible contribution to late organ complications? Diabetes Res, 1992, 19: 31-35.
41. Zhang X L, Wang X M, Liao L S. The significance of hemorheology changes in patients with diabetic nephropathy (in Chinese). Chin J Nephrol, 1993, 9: 348-349.
42. Khodabandehlou T, Vimeux M, Le Devehat C. Measurements of transcutaneous oxygen pressure and changes in blood rheology as markers of prognosis of critically ischemic limb in diabetes mellitus patients. Int J Low Extrem Wounds, 2003, 2: 13-18.
43. Cohen R A. Role of nitric oxide in diabetic complications. Am J Ther, 2005, 12: 499-502.
44. Le Devehat C, Vimeux M, Khodabandehlou T. Blood rheology in patients with diabetes mellitus. Clin Hemorheol Microcirc, 2004, 30: 297-300.
45. Giansanti R, Rabini R A, Boemi M. Blood rheology changes and disturbances in microcirculation. Clin Hernorheol, 1996, 16: 543-548.
46. Vigilance J E, Reid H L. Glycaemic control influences peripheral blood flow and haemorheological variables in patients with diabetes mellitus. Clin Hemorheol Microcirc, 2005, 33: 337-346.
47. Zanazzi M, Fatini C, Farsetti S, et al. Blood rheology and renal transplantation: An intriguing relationship for assessing cardiovascular risk. Transplant Proc, 2010, 42: 1383-1384.
48. Booth S, Chohan S, Curran J C, et al. Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus. Arthritis Rheum, 2007, 57: 845-850.
49. Smith M M, Chen P C Y, Li C S, et al. Whole blood viscosity and microvascular abnormalities in Alzheimer's Disease. Clin Hemorheol Microcirc, 2009, 41: 229-239.
50. Chew S H, Tomic M M S, Cheung A T W. Alzheimer's disease: More than amyloid. Clin Hemorheol Microcirc, 2010, 46: 69-73.
51. Omoti C E, Omuemu C E, Olu-Eddo A N. The rheological profile of chronic liver disease patients in Nigeria. Clin Hemorheol Microcirc, 2009, 42: 279-284.
52. Gokturk H S, Demir M, Ozturk N A, et al. Plasma viscosity changes in patients with liver cirrhosis. South Med J, 2009, 102: 1013-1018.
53. Fang N, Jiang L X, Zhang X S. Clinical observation of blood viscosity in patients with viral hepatitis (in Chinese). Chin J Hemorh, 2000, 10: 240-241.
54. Halis H, Bor-Kucukatay M, Akin M, et al. Hemorheological parameters in children with iron-deficiency anemia and the alterations in these parameters in response to iron replacement. Pediatr Hematol Oncol, 2009, 26: 108-118.
55. Zhao L, Wang B, You G X, et al. Effects of different resuscitation fluids on the rheologic behavior of red blood cells, blood viscosity and plasma viscosity in experimental hemorrhagic shock. Resuscitation, 2009, 80: 253-258.
56. Wettstein R, Erni D, Intaglietta M, et al. Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock. Shock, 2006, 25: 641-646.
57. Wettstein R, Tsai A G, Erni D, et al. Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock. Shock, 2004, 21: 235-240.
58. Zhao L, You G X, Zhou H. High viscosity plasma expander is beneficial for resuscitation of hemorrhagic shock (in Chinese). J Int Pharm Res, 2008, 35: 360-363.
59. Kilpatrick D, Fleming J, Clyne C, et al. Reduction of blood viscosity following plasma exchange. Atherosclerosis, 1979, 32: 301-306.
60. Brown M M, Marshall J. Effect of plasma exchange on blood viscosity and cerebral blood flow. Br Med J (Clin Res Ed), 1982, 284: 1733-1736.
61. Cliville X, Bofill C, Joven J, et al. Hemorheological, coagulative and fibrinolytic changes during autologous blood donation. Clin Hemorheol Microcirc, 1998, 18: 265-272.
62. DeFilippis A P, Law K, Curtin S, et al. Blood is thicker than water: The management of hyperviscosity in adults with cyanotic heart disease. Cardiol Rev, 2007, 15: 31-34.
63. Strand T, Asplund K, Eriksson S, et al. A randomized controlled trial of hemodilution therapy in acute ischemic stroke. Stroke, 1984, 15: 980-989.
64. Ferrannini M, Vischini G, Staffolani E, et al. Rheopheresis in vascular diseases. Int J Artif Organs, 2007, 30: 923-929.
65. Dou M, Ma A G, Wang Q Z, et al. Supplementation with magnesium and vitamin E were more effective than magnesium alone to decrease plasma lipids and blood viscosity in diabetic rats. Nutr Res, 2009, 29: 519-524.
66. Chung T W, Yu J J H, Liu D Z. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med, 1998, 15: 380-385.
67. Feng X L, Jin Y H, Lin J H. Effects of the purified oil of Anguilla japonica and vitamin E on the concentration of blood fibrinogen and the blood viscosity of rat (in Chinese). Acad J First Med Coll PLA, 1999, 19: 122-123.
68. Bin J P, Doctor A, Lindner J, et al. Effects of nitroglycerin on erythrocyte rheology and oxygen unloading-Novel role of S-nitrosohe-moglobin in relieving myocardial ischemia. Circulation, 2006, 113: 2502-2508.
69. Hou W C, Tsay H S, Liang H J, et al. Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge. J Ethnopharmacol, 2007, 111: 483-489.
70. Fan H Y, Fu F H, Yang M Y, et al. Antiplatelet and antithrombotic activities of salvianolic acid A. Thromb Res, 2010, 126: 17-22.
71. Tian J W, Fu F H, Jiang W L, et al. Protective effect of Ligulsticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action. Zhongguo Zhongyao Zazhi, 2005, 30: 466-468.
72. Naito T, Kubota K, Shimoda Y, et al. Effects of constituents in a Chinese crude drug, Ligustici chuanxiong Rhizoma on vasocontraction and blood viscosity. Nat Med, 1995, 49: 288-292.
73. Liu J X, Li H Y, Mu Y J, et al. The effect of Qigen Xingnao Prescriptionon on platelet aggregation, thrombosis and hemorrheology (in Chinese). Chin Tradit Pat Med, 2007, 30: 756-758.
74. Salazar Vquez B Y, Wettstein R, Cabrales P, et al. Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation. Biochim Biophys Acta, 2008, 1784: 1421-1427.
75. Cabrales P, Intaglietta M, Tsai A G. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation, 2007, 75: 124-134.
76. Cabrales P, Tsai A G, Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity? Shock, 2007, 27: 380-389.
77. Martini J, Tsai A G, Cabrales P, et al. Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model. Am J Physiol Heart Circ Physiol, 2006, 291: 310-317.
78. Hess J R, MacDonald V W, Brinkley W W. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol, 1993, 74: 1769-1778.
79. Keipert P E, Gonzales A, Gomez C L, et al. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion, 1993, 33: 701-708.
80. Hess J R, MacDonald V W, Winslow R M. Dehydration and shock: An animal model of hemorrhage and resuscitation of battlefield injury. Biomater Artif Cells Immobilization Biotechnol, 1992, 20: 499-502.
81. Caron A, Malfatti E, Aguejouf O, et al. Vasoconstrictive response of rat mesenteric arterioles following infusion of cross-linked, polymerized, and conjugated hemoglobin solutions. Artif Cells Blood Substit Immobil Biotechnol, 2001, 29: 19-30.
82. Winslow R M, Gonzales A, Gonzales M I, et al. Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model. J Appl Physiol, 1998, 85: 993-1003.
83. Rochon G, Caron A, Toussaint-Hacquard M, et al. Hemodilution with stoma-free hemoglobin at physiologically maintained viscosity delays the onset of vasoconstriction. Hypertension, 2004, 43: 1110-1115.
84. Tsai A G, Acero C, Nance P R, et al. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol, 2005, 288: 1730-1739.
85. Tsai A G, Friesenecker B, McCarthy M, et al. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model. Am J Physiol Heart Circ Physiol, 1998, 275: 2170-2180.
86. Cabrales P, Tsai A G, Intaglietta M. Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock. Resuscitation, 2008, 77: 379-386.
87. Tok D, Caliskan M, Gullu H, et al. The association between hematological parameters and coronary flow reserve and coronary haemorheology in healthy subjects. Clin Hemorheol Microcirc, 2007, 36: 345-352.
88. Starzyk D, Korbut R, Gryglewski R J. Effects of nitric oxide and prostacyclin on deformability and aggregability of red blood cells of rats ex vivo and in vitro. J Physiol Pharmacol, 1999, 50: 629-637.
89. Bor-Kucukatay M, Wenby R B, Meiselman H J, et al. Effects of nitric oxide on red blood cell deformability. Am J Physiol Heart Circ Physiol, 2003, 284: 1577-1584.
90. Dangel O, Mergia E, Karlisch K, et al. Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition. J Thromb Haemost, 2010, 8: 1343-1352.
91. Malek A, Izumo S. Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol-Cell Ph, 1992, 263: 389-396.
92. Koller A, Sun D, Kaley G. Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro. Circ Res, 1993, 72: 1276-1284.
93. Bertuglia S. Increased viscosity is protective for arteriolar endothelium and microvascular perfusion during severe hemodilution in hamster cheek pouch. Microvasc Res, 2001, 61: 56-63.
94. Byfield F J, Reen R K, Shentu T P, et al. Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D. J Biomech, 2009, 42: 1114-1119.
95. Chowdhury F, Li Y Z, Poh Y C, et al. Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions. PLoS One, 2010, 5: e15655.
96. Tee S Y, Fu J P, Chen C S, et al. Cell shape and substrate rigidity both regulate cell stiffness. Biophys J, 2011, 100: 25-27.
97. Liao F L, Li M, Han D, et al. Biomechanopharmacology: A new borderline discipline. Trends Pharmacol Sci, 2006, 27: 287-289.
98. Chiu J J, Chien S. Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev, 2011, 91: 327-387.
99. Zhao L, Wang B, You G X, et al. Hemorrheological changes in irreversible hemorrhagic shock (in Chinese). Chin Crit Care Med, 2008, 20: 159-162.
100. Zhao L, Wang B, You G X, et al. Effects of different resuscitation fluids on the rheologic behavior of red blood cells, blood viscosity and plasma viscosity in experimental hemorrhagic shock. Resuscitation, 2009, 80: 253-258.
101. Zhao L, You G X, Liao F L, et al. Sodium alginate as viscosity modifier may induce aggregation of red blood cells. Artif Cells Blood Substit Immobil Biotechnol, 2010, 38: 267-276.