Whole blood viscosity and microvascular abnormalities in alzheimer's disease

Clinical Hemorheology and Microcirculation

Volumn 41, Issue 4, 2009, Pages 229-239

  Smith, M Meighan ^a   Chen, Peter C Y ^b   Li, Chin Shang ^a   Ramanujam, Sahana ^a   Cheung, Anthony T W ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS CLINIC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's Disease; Hemorheology; Intravital microscopy; Microcirculation; Whole blood viscosity (WBV)

Indexed keywords

DONEPEZIL;

ALZHEIMER DISEASE; ARTICLE; BLOOD ANALYSIS; BLOOD FLOW VELOCITY; BLOOD RHEOLOGY; BLOOD VESSEL DIAMETER; BLOOD VISCOSITY; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; DEVICE; DISEASE SEVERITY; HUMAN; MICROANGIOPATHY; MICROCIRCULATION; MICROSCOPY; SHEAR STRESS; VASCULAR DISEASE; BLOOD; EYE; IMAGE PROCESSING; PATHOLOGY; VASCULARIZATION;

ALZHEIMER DISEASE; BLOOD FLOW VELOCITY; BLOOD VISCOSITY; EYE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROCIRCULATION;

EID: 65549106450     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: 10.3233/CH-2009-1174     Document Type: Article

References (40)

1. H.S. Akiyama, S. Barger, B. Barnum et al., Inflammation and Alzheimer's disease, Neurobiol. Aging 21 (2000), 383-421.
2. T.M. Berzin, B.D. Zipser, M.S. Rafii et al., Agrin and microvascular damage in Alzheimer's disease, Neurobiol. Aging 21 (2000), 349-355.
3. L. Buee, P.R. Hof and A. Delacourte, Brain microvascular changes in Alzheimer's disease and other dementias, Ann. N. Y. Acad. Sci. 826 (1997), 7-24.
4. P. Grammas and R. Ovase, Inflammatory factors are elevated in brain microvessels in Alzheimer's disease, Neurobiol. Aging 22 (2001), 837-842.
5. L. Thirumangalakudi, P.G. Samany, A. Owoso et al., Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease, J. Alzheimers Dis. 10 (2006), 111-118.
6. A.T. Du, G.H. Jahng, S. Hayasaka et al., Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI, Neurology 67 (2006), 1215-1220.
7. C. Iadecola, Neurovascular regulation in the normal brain and in Alzheimer's disease, Nat. Rev. Neurosci. 5 (2004), 347-360.
8. N.A. Johnson, G.H. Jahng, M.W. Weiner et al., Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience, Radiology 234 (2005), 851-859.
9. K. Niwa, K. Kazama, L. Younkin et al., Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein, Am. J. Physiol. Heart Circ. Physiol. 283 (2002), H315-H323.
10. K. Niwa, K. Kazama, S.G. Younkin et al., Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein, Neurobiol. Dis. 9 (2002), 61-68.
11. K. Niwa, L. Younkin, C. Ebeling et al., Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation, Proc. Natl. Acad. Sci. USA 97 (2000), 9735-9740.
12. M. Silvestrini, P. Pasqualetti, R. Baruffaldi et al., Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease, Stroke 37 (2006), 1010-1015.
13. 2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease, Ann. N. Y. Acad. Sci. 1097 (2007), 40-50.
14. J.A. Luchsinger, C. Reitz, L.S. Honig et al., Aggregation of vascular risk factors and risk of incident Alzheimer disease, Neurology 65 (2005), 545-551.
15. L. White and L. Launer, Relevance of cardiovascular risk factors and ischemic cerebrovascular disease to the pathogenesis of Alzheimer disease: a review of accrued findings from the Honolulu-Asia Aging Study, Alzheimer Dis. Assoc. Disord. 20(3 Suppl. 2) (2006), S79-S83.
16. M.S. Beeri, M. Rapp, J.M. Silverman et al., Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers, Neurology 66 (2006), 1399-1404.
17. J.A. Johnston, W.W. Liu, S.A. Todd et al., Mechanisms of peripheral microvascular dysfunction in transgenic mice over-expressing the Alzheimer's disease amyloid Abeta protein, J. Alzheimers Dis. 4 (2002), 467-478.
18. R.S. Ajmani, E.J. Metter, R. Jaykumar et al., Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function, Neurobiol. Aging 21 (2000), 257-269.
19. S.B. Solerte, G. Ceresini, E. Ferrari and M. Fioravanti, Hemorheological changes and overproduction of cytokines from immune cells in mild to moderate dementia of the Alzheimer's type: adverse effects on cerebromicrovascular system, Neurobiol. Aging 21 (2000), 271-281.
20. Z. Wen, J. Xie, Z. Guan et al., A study of hemorheological behaviour for patients with Alzheimer's disease at the early stages, Clin. Hemorheol. Microcirc. 22 (2000), 261-266.
21. S. Chien, Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell, Am. J. Physiol. Heart Circ. Physiol. 292 (2007), H1209-H1224.
22. G. Garcia-Cardena, J. Comander, K.R. Anderson et al., Biomechanical activation of vascular endothelium as a determinant of its functional phenotype, Proc. Natl. Acad. Sci. USA 98 (2001), 4478-4485.
23. G. Garcia-Cardena and M.A. Gimbrone, Jr., Biomechanical modulation of endothelial phenotype: implications for health and disease, Handb. Exp. Pharmacol. 176 (2006), 79-95.
24. I. Cicha, M. Goppelt-Struebe, A. Yilmaz et al., Endothelial dysfunction and monocyte recruitment in cells exposed to non-uniform shear stress, Clin. Hemorheol. Microcirc. 39 (2008), 113-119.
25. A. Kadi, N. de Isla, P. Lacolley et al., Potential relation between cytoskeleton reorganization and e-NOS activity in sheared endothelial cells (Effect of rate and time of exposure), Clin. Hemorheol. Microcirc. 37 (2007), 131-140.
26. R. Lo Presti, D. Sinagra, M. Montana, A.M. Scarpitta, A. Catania and G. Caimi, Haemorheological profile in metabolic syndrome, Clin. Hemorheol. Microcirc. 26 (2002), 241-247.
27. M. Woodward, A. Rumley, H. Tunstall-Pedoe and G.D. Lowe, Associations of blood rheology and interleukin-6 with cardiovascular risk factors and prevalent cardiovascular disease, Br. J. Haematol. 104 (1999), 246-257.
28. B.K. Lee, A. Durairaj, A. Mehra et al., Hemorheological abnormalities in stable angina and acute coronary syndromes, Clin. Hemorheol. Microcirc. 39 (2008), 43-51.
29. I. Velcheva, N. Antonova, E. Titianova et al., Hemorheological disturbances in cerebrovascular disease, Clin. Hemorheol. Microcirc. 39 (2008), 391-396.
30. E. Zorio, J. Murado, D. Arizo et al., Haemorheological parameters in young patients with acute myocardial infarction, Clin. Hemorheol. Microcirc. 39 (2008), 33-41.
31. E. Solá, A Vayá, M. Simó et al., Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistence, Clin. Hemorheol. Microcirc. 37 (2007), 309-318.
32. G. McKhann, D. Drachman, M. Folstein et al., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology 34 (1984), 939-944.
33. M.F. Folstein, S.E. Folstein and P.R. McHugh, "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician, J. Psychiatr. Res. 12 (1975), 189-198.
34. A.T. Cheung, P.C. Chen, E.C. Larkin et al., Microvascular abnormalities in sickle cell disease: a computer-assisted intrav-ital microscopy study, Blood 99 (2002), 3999-4005.
35. A.T. Cheung, R.V. Perez and P.C. Chen, Improvements in diabetic microangiopathy after successful simultaneous pancreas-kidney transplantation: a computer-assisted intravital microscopy study on the conjunctival microcirculation, Transplantation 68 (1999), 927-932.
36. A.T. Cheung, A.R. Price, P.L. Duong et al., Microvascular abnormalities in pediatric diabetic patients, Microvasc. Res. 63 (2002), 252-258.
37. S. Kim, Y. Cho, W.N. Hogenauer and K. Kensey, A method of isolating surface tension and yeald stress effects in a U-shaped scanning capillary-tube viscometer using a Casson model, Journal of Non-Newtownian Fluid Mechanics 103 (2002), 205-219.
38. T. Alexy, E. Pais, R.B. Wenby et al., Measurement of whole blood viscosity profiles via an automated viscometer: technical details and clinical relevance, Clin. Lab. 51 (2005), 523-529.
39. T. Alexy, R.B. Wenby, E. Pais et al., An automated tube-type blood viscometer: validation studies, Biorheology 42 (2005), 237-247.
40. Y.I. Cho, L.H. Back, D.W. Crawford et al., Experimental study of pulsatile and steady flow through a smooth tube and an atherosclerotic coronary artery casting of man, J. Biomech. 16 (1983) 933-946.