Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock

Shock

Volumn 25, Issue 6, 2006, Pages 641-646

  Wettstein, Reto ^a,b   Erni, Dominique ^c   Intaglietta, Marcos ^a,d   Tsai, Amy G ^a,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d LA JOLLA BIOENGINEERING INSTITUTE   (United States)

Author keywords

Cardiac output; Colloid osmotic pressure; Functional capillary density; Hamster; Hydroxyethyl starch; Microcirculation; Plasma expander; Plasma viscosity

Indexed keywords

HETASTARCH; OXYGEN; PLASMA SUBSTITUTE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD FLOW; BLOOD VOLUME; CONTROLLED STUDY; HAMSTER; HEART INDEX; HEMORRHAGIC SHOCK; MALE; MEAN ARTERIAL PRESSURE; METABOLISM; MICROCIRCULATION; MICROSCOPY; NONHUMAN; ONCOTIC PRESSURE; OXYGEN CONSUMPTION; PLASMA VISCOSITY; RESUSCITATION; SKINFOLD; TRANSFUSION; WAKEFULNESS; ANIMAL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BLOOD VISCOSITY; COMPARATIVE STUDY; DRUG EFFECT; HEART OUTPUT; PATHOPHYSIOLOGY; SYRIAN HAMSTER; VISCOSITY;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BLOOD VISCOSITY; CARDIAC OUTPUT; CRICETINAE; HETASTARCH; MALE; MESOCRICETUS; MICROCIRCULATION; OXYGEN CONSUMPTION; PLASMA SUBSTITUTES; RESUSCITATION; SHOCK, HEMORRHAGIC; VISCOSITY;

EID: 33745620802     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000209532.15317.15     Document Type: Article

References (22)

1. Moore FA, Moore EE, Sauaia A: Blood transfusion. An independent risk factor for postinjury multiple organ failure. Arch Surg 132:620-624, 1997.
2. Farion KJ, McLellan BA, Boulanger BR, et al. Changes in red cell transfusion practice among adult trauma victims. J Trauma 44:583-587, 1998.
3. Wettstein R, Tsai AG, Erni D, et al. Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock. Shock 21:235-240, 2004.
4. Kerger H, Waschke KF, Ackern KV, et al. Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock. Am J Physiol 276:H2035-H2043, 1999.
5. Tsai AG, Friesenecker B, McCarthy M, et al. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skinfold model. Am J Physiol 275:H2170-H2180, 1998.
6. Bertuglia S: Increased viscosity is protective for arteriolar endothelium and microvascular perfusion during severe hemodilution in hamster cheek pouch. Microvasc Res 61:56-63, 2001.
7. Tsai AG, Intaglietta M: High viscosity plasma expanders: volume restitution fluids for lowering the transfusion trigger. Biorheology 38:229-237, 2001.
8. Cabrales P, Tsai AG, Intaglietta M: Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock. 22:431-437, 2004.
9. Boura C, Caron A, Longrois D, et al. Volume expansion with modified hemoglobin solution, colloids, or crystalloid after hemorrhagic shock in rabbits: effects in skeletal muscle oxygen pressure and use versus arterial blood velocity and resistance. Shock 19:176-182, 2003.
10. Boldt J, Lenz M, Kumle B, et al. Volume replacement strategies on intensive care units: results from a postal survey. Intensive Care Med 24:147-151, 1998.
11. Treib J, Baron JF, Grauer MT, et al. An international view of hydroxyethyl starches. Intensive Care Med 25:258-268, 1999.
12. Dieterich HJ: Recent developments in European colloid solutions. J Trauma 54:S26-S30, 2003.
13. Cabrales P, Acero C, Intaglietta M, et al. Measurement of the cardiac output in small animals by thermodilution. Microvasc Res 66:77-82, 2003.
14. 2 measurements in arteriolar networks. Microvasc Res 51:202-212, 1996.
15. Wettstein R, Tsai AG, Erni D, et al. Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Crit Care Med 31:1824-1830, 2003.
16. Wettstein R, Cabrales P, Erni D, et al. Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin. Shock 22:351-357, 2004.
17. 2 affinity. Am J Physiol 276:H553-H562, 1999.
18. Kutscher C: Plasma volume change during water-deprivation in gerbils, hamsters, guinea pigs and rats. Comp Biochem Physiol 25:929-936, 1968.
19. Berg S, Golster M, Lisander B: Albumin extravasation and tissue washout of hyaluronan after plasma volume expansion with crystalloid or hypooncotic colloid solutions. Acta Anaesthesiol Scand 46:166-172, 2002.
20. Mirhashemi S, Breit GA, Chavez Chavez RH, et al. Effects of hemodilution on skin microcirculation. Am J Physiol 254:H411-H416, 1988.
21. Handrigan MT, Bentley TB, Oliver JD, et al. Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats. Shock 23:337-343, 2005.
22. Schortgen F, Lacherade JC, Bruneel F, et al. Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet 357:911-916, 2001.