Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure

Environmental Health Perspectives

Volumn 117, Issue 5, 2009, Pages 716-722

  Stout, Matthew D ^a   Herbert, Ronald A ^a   Kissling, Grace E ^a   Collins, Bradley J ^a   Travios, Gregory S ^a   Witt, Kristine L ^a   Melnick, Ronald L ^a   Abdo, Kamal M ^a   Melarkey, David E ^a   Hooth, Michelle J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Anemia; Cancer; Hexavalent chromium; Histiocytic cellular infiltration; National Toxicology Program; Oral cavity; Small intestine

Indexed keywords

DICHROMATE SODIUM; DRINKING WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CARCINOGENICITY; CELL INFILTRATION; CONTROLLED STUDY; DUODENUM; FEMALE; FISCHER 344 RAT; FLUID INTAKE; HYPERPLASIA; INCIDENCE; IRON DEFICIENCY ANEMIA; JEJUNUM; MALE; MESENTERY LYMPH NODE; MICROCYTOSIS; MOUSE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE CANCER; SMALL INTESTINE CARCINOMA; SQUAMOUS CELL CARCINOMA; TONGUE CARCINOMA; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CHROMIUM; FEMALE; MALE; MICE; MOUTH; MOUTH NEOPLASMS; RATS; RATS, INBRED F344;

MUS; RATTUS; RODENTIA;

EID: 66349100127     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0800208     Document Type: Article

References (52)

1. Agency for Toxic Substances and Disease Registry. 2000. Toxicological Profile for Chromium. Atlanta, GA:Agency for Toxic Substances and Disease Registry.
2. Bailer AJ, Portier CJ. 1988. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcino-genicity in small samples. Biometrics 44:417-431.
3. Beaumont JJ, Sedman RM, Reynolds SD, Sherman CD, Li LH, Howd RA, et al. 2008. Cancer mortality in a Chinese population exposed to hexavalent chromium in drinking water. Epidemiology 19:12-23.
4. Boorman GA, Montgomery CA Jr, Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF. 1985. Quality assurance in pathology for rodent carcinogenicity studies. In: Handbook of Carcinogen Testing (Milman HA, Weisburger EK, eds). Park Ridge, NJ:Noyes Publications, 345-357.
5. Borneff J, Engelhardt K, Griem W, Kunte H, Reichert J. 1968. Carcinogens in water and soil. XXII. Experiment with 3,4-benzopyrene and potassium chromate in mice drink [in German]. Arch Hyg Bakteriol 152:45-53.
6. CDPH (California Department of Public Health). 2007a. Chromium-6 in Drinking Water Standard: Sampling Results. Available: http://ww2.cdph.ca.gov/certlic/drinkingwater/Pages/ Chromium6sampling.aspx [accessed 10 November 2008].
7. CDPH (California Department of Public Health). 2007b. Chromium-6 in Drinking Water: Regulation Update. Available: http://ww2.cdph.ca.gov/ certlic/drinkingwater/Pages/Chromium6.aspx [accessed 10 November 2008].
8. Chorvatovicova D, Ginter E, Kosinova A, Zloch Z. 1991. Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium in rat and guinea pig. Mutat Res 262:41-46.
9. Cohen MD, Kargacin B, Klein CB, Costa M. 1993. Mechanisms of chromium carcinogenicity and toxicity. Crit Rev Toxicol 23:255-281.
10. Costa M. 1997. Toxicity and carcinogenicity of Cr(VI) in animal models and humans. Crit Rev Toxicol 27:431-442.
11. Costa M, Klein CB. 2006. Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol 36:155-163.
12. Cox DR. 1972. Regression models and life-tables. J R Stat Soc B34:187-220.
13. De Flora S. 2000. Threshold mechanisms and site specificity in chromium(VI) carcinogenesis. Carcinogenesis 21:533-541.
14. De Flora S, Bagnasco M, Serra D, Zanacchi P. 1990. Genotoxicity of chromium compounds. A review. Mutat Res 238:99-172.
15. De Flora S, Camoirano A, Bagnasco M, Bennicilli C, Corbett GE, Kerger BD. 1997. Estimates of the chromium (VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity. Carcinogenesis 18:531-537.
16. De Flora S, D'Agostini F, Balansky R, Micale R, Baluce B, Izzotti A. 2008. Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water. Mutat Res 659:60-67.
17. Dixon WJ, Massey FJ Jr. 1957. Introduction to Statistical Analysis. 2nd ed. New York:McGraw-Hill.
18. Donaldson RM Jr, Barreras RF. 1966. Intestinal absorption of trace quantities of chromium. J Lab Clin Med 68:484-493.
19. Dunn OJ. 1964. Multiple comparisons using rank sums. Technometrics 6:241-252.
20. Dunnett CW. 1955. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121.
21. Febel H, Szegedi B, Huszar S. 2001. Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats. Acta Vet Hung 49:203-209.
22. Food and Drug Administration. 1987. Good laboratory practice regulations. Final rule. 21 CFR 58. Fed Reg 52(172):33768-33782.
23. International Agency for Research on Cancer. 1990. Chromium. IARC Monogr Eval Carcinog Risks Hum 49:49-256.
24. Jonckheere AR. 1954. A distribution-free k-sample test against ordered alternatives. Biometrika 41:133-145.
25. Kaplan EL, Meier P. 1958. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481.
26. Maronpot RR, Boorman GA. 1982. Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicol Pathol 10:71-80.
27. McConnell EE, Solleveld HA, Swenberg JA, Boorman GA. 1986. Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. J Natl Cancer Inst 76:283-289.
28. National Cancer Institute. 1977. Bioassay of Captan for Possible Carcinogenicity (CAS No. 133-06-2). Technical Report 15. Bethesda, MD:National Cancer Institute.
29. National Research Council. 1996. Guide for the Care and Use of Laboratory Animals. Washington, DC:National Academies Press.
30. Neter J, Kutner MH, Nachtsheim CJ, Wasserman W. 1996. Applied Linear Statistical Models. 4th ed. Boston:WCB McGraw-Hill, 115-124.
31. 1 Mice (Gavage Studies). TR 384. Research Triangle Park, NC:National Toxicology Program.
32. NTP. 1998. Report on Carcinogens. 8th ed. Research Triangle Park, NC:National Toxicology Program.
33. 1 Mice and Male BALB/c and am3-C57BL/6 Mice. TOX 72. Research Triangle Park, NC:National Toxicology Program.
34. 1 Mice (Drinking Water Studies). TR 546. Research Triangle Park, NC:National Toxicology Program.
35. 1 Mice (Feed Studies) [draft]. TR 556. Research Triangle Park, NC:National Toxicology Program.
36. O'Brien TJ, Ceryak S, Patierno SR. 2003. Complexities of chromium carcinogenesis: Role of cellular response, repair, and recovery mechanisms. Mutat Res 533:3-36.
37. Pellerin C, Booker SM. 2000. Reflections on hexavalent chromium: health hazards of an industrial heavyweight. Environ Health Perspect 108:A402-A407.
38. Piegorsch WW, Bailer AJ. 1997. Statistics for Environmental Biology and Toxicology. London:Chapman and Hall.
39. Portier CJ, Bailer AJ. 1989. Testing for increased carcino-genicity using a survival-adjusted quantal response test. Fundam Appl Toxicol 12:731-737.
40. Proctor DM, Otani JM, Finley BL, Paustenbach DJ, Bland JA, Speizer N, et al. 2002. Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review. J Toxicol Environ Health A 65:701-746.
41. Quievryn G, Messer J, Zhitkovich A. 2006. Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate. Carcinogenesis 27:2316-2321.
42. Reynolds M, Stoddard L, Bespalov I, Zhitkovich A. 2007. Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair. Nucleic Acids Res 35:465-476.
43. Sedman RM, Beaumont J, McDonald TA, Reynolds S, Krowech G, Howd R. 2006. Review of the evidence regarding the carcinogenicity of hexavalent chromium in drinking water. J Environ Sci Health C 24:155-182.
44. Shackelford CC, Elwell MR. 1999. Small and large intestine, and mesentery. In: Pathology of the Mouse (Maronpot RR, ed). Vienna, IL:Cache River Press, 81-118.
45. Shirley E. 1977. A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33:386-389.
46. Standeven AM, Wetterhahn KE. 1991. Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis? Chem Res Toxicol 4:616-625.
47. Tarone RE. 1975. Tests for trend in life table analysis. Biometrika 62:679-682.
48. U.S. EPA (Environmental Protection Agency). 2003. National primary drinking water regulations. 40CFR141.62. Available: http://edocket.access.gpo.gov/cfr_2003/julqtr/40cfr141.62.htm [accessed 3 April 2009]
49. U.S. EPA 1998. Toxicological Review of Hexavalent Chromium (CAS No. 18540-29-9). In Support of Summary Information on the Integrated Risk Information System (IRIS). Washington DC:U.S. Environmental Protection Agency.
50. Williams DA. 1986. A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control. Biometrics 42:183-186.
51. Zhang JD, Li XL. 1987. Chromium pollution of soil and water in Jinzhou [in Chinese]. Zhonghua Yu Fang Yi Xue Za Zhi 21:262-264.
52. Zhitkovich A. 2005. Importance of chromium - DNA adducts in mutagenicity and toxicity of chromium (VI). Chem Res Toxicol 18:3-9.