Type III Effector VopC Mediates Invasion for Vibrio Species

Cell Reports

Volumn 1, Issue 5, 2012, Pages 453-460

  Zhang, Lingling ^a   Krachler, Anne Marie ^a   Broberg, Christopher A ^a,c   Li, Yan ^a   Mirzael, Hamid ^a   Gilpin, Christopher J ^a   Orth, Kim ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN VOPC; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CELL INVASION; CELL VACUOLE; CONTROLLED STUDY; HOST CELL; HOST PATHOGEN INTERACTION; INTRACELLULAR BACTERIUM; NONHUMAN; TYPE III SECRETION SYSTEM; VIBRIO; VIBRIO CHOLERAE; VIBRIO PARAHAEMOLYTICUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CDC42 GTP-BINDING PROTEIN; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; RAC GTP-BINDING PROTEINS; VIBRIO; VIBRIO CHOLERAE; VIBRIO INFECTIONS; VIBRIO PARAHAEMOLYTICUS; VIRUS REPLICATION;

VIBRIO; VIBRIO CHOLERAE; VIBRIO PARAHAEMOLYTICUS;

EID: 84861685150     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.04.004     Document Type: Article

References (27)

1. Akeda Y., Nagayama K., Yamamoto K., Honda T. Invasive phenotype of Vibrio parahaemolyticus. J. Infect. Dis. 1997, 176:822-824.
2. Aktories K., Barbieri J.T. Bacterial cytotoxins: targeting eukaryotic switches. Nat. Rev. Microbiol. 2005, 3:397-410.
3. Broberg C.A., Orth K. Tipping the balance by manipulating post-translational modifications. Curr. Opin. Microbiol. 2010, 13:34-40.
4. Broberg C.A., Calder T.J., Orth K. Vibrio parahaemolyticus cell biology and pathogenicity determinants. Microbes Infect. 2011, 13:992-1001.
5. Dalsgaard A., Albert M.J., Taylor D.N., Shimada T., Meza R., Serichantalergs O., Echeverria P. Characterization of Vibrio cgolerae non-O1 serogroups obtained from an outbreak of diarrhea in Lima, Peru. J. Clin. Microbiol. 1995, 33:2715-2722.
6. Doye A., Mettouchi A., Bossis G., Clément R., Buisson-Touati C., Flatau G., Gagnoux L., Piechaczyk M., Boquet P., Lemichez E. CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell 2002, 111:553-564.
7. Flatau G., Lemichez E., Gauthier M., Chardin P., Paris S., Fiorentini C., Boquet P. Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature 1997, 387:729-733.
8. Gotoh K., Kodama T., Hiyoshi H., Izutsu K., Park K.S., Dryselius R., Akeda Y., Honda T., Iida T. Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants. PLoS ONE 2010, 5:e13365.
9. Ham H., Sreelatha A., Orth K. Manipulation of host membranes by bacterial effectors. Nat. Rev. Microbiol. 2011, 9:635-646.
10. Hiyoshi H., Kodama T., Saito K., Gotoh K., Matsuda S., Akeda Y., Honda T., Iida T. VopV, an F-actin-binding type III secretion effector, is required for Vibrio parahaemolyticus-induced enterotoxicity. Cell Host Microbe 2011, 10:401-409.
11. Horiguchi Y. Escherichia coli cytotoxic necrotizing factors and Bordetella dermonecrotic toxin: the dermonecrosis-inducing toxins activating Rho small GTPases. Toxicon 2001, 39:1619-1627.
12. Kodama T., Rokuda M., Park K.S., Cantarelli V.V., Matsuda S., Iida T., Honda T. Identification and characterization of VopT, a novel ADP-ribosyltransferase effector protein secreted via the Vibrio parahaemolyticus type III secretion system 2. Cell Microbiol. 2007, 9:2598-2609.
13. Kodama T., Gotoh K., Hiyoshi H., Morita M., Izutsu K., Akeda Y., Park K.S., Cantarelli V.V., Dryselius R., Iida T., Honda T. Two regulators of Vibrio parahaemolyticus play important roles in enterotoxicity by controlling the expression of genes in the Vp-PAI region. PLoS ONE 2010, 5:e8678.
14. Liverman A.D., Cheng H.C., Trosky J.E., Leung D.W., Yarbrough M.L., Burdette D.L., Rosen M.K., Orth K. Arp2/3-independent assembly of actin by Vibrio type III effector VopL. Proc. Natl. Acad. Sci. USA 2007, 104:17117-17122.
15. Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., et al. Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae. Lancet 2003, 361:743-749.
16. Masuda M., Betancourt L., Matsuzawa T., Kashimoto T., Takao T., Shimonishi Y., Horiguchi Y. Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin. EMBO J. 2000, 19:521-530.
17. Merriam J.J., Mathur R., Maxfield-Boumil R., Isberg R.R. Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect. Immun. 1997, 65:2497-2501.
18. Nishibuchi M., Kaper J.B. Thermostable direct hemolysin gene of Vibrio parahaemolyticus: a virulence gene acquired by a marine bacterium. Infect. Immun. 1995, 63:2093-2099.
19. Okada N., Iida T., Park K.S., Goto N., Yasunaga T., Hiyoshi H., Matsuda S., Kodama T., Honda T. Identification and characterization of a novel type III secretion system in trh-positive Vibrio parahaemolyticus strain TH3996 reveal genetic lineage and diversity of pathogenic machinery beyond the species level. Infect. Immun. 2009, 77:904-913.
20. Okada K., Chantaroj S., Taniguchi T., Suzuki Y., Roobthaisong A., Puiprom O., Honda T., Sawanpanyalert P. A rapid, simple, and sensitive loop-mediated isothermal amplification method to detect toxigenic Vibrio cholerae in rectal swab samples. Diagn. Microbiol. Infect. Dis. 2010, 66:135-139.
21. Okada N., Matsuda S., Matsuyama J., Park K.S., de los Reyes C., Kogure K., Honda T., Iida T. Presence of genes for type III secretion system 2 in Vibrio mimicus strains. BMC Microbiol. 2010, 10:302.
22. Park K.-S., Ono T., Rokuda M., Jang M.-H., Okada K., Iida T., Honda T. Functional characterization of two type III secretion systems of Vibrio parahaemolyticus. Infect. Immun. 2004, 72:6659-6665.
23. Park K.S., Ono T., Rokuda M., Jang M.H., Iida T., Honda T. Cytotoxicity and enterotoxicity of the thermostable direct hemolysin-deletion mutants of Vibrio parahaemolyticus. Microbiol. Immunol. 2004, 48:313-318.
24. Schmidt G., Sehr P., Wilm M., Selzer J., Mann M., Aktories K. Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature 1997, 387:725-729.
25. Trosky J.E., Li Y., Mukherjee S., Keitany G., Ball H., Orth K. VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. J. Biol. Chem. 2007, 282:34299-34305.
26. Walker K.A., Miller V.L. Regulation of the Ysa type III secretion system of Yersinia enterocolitica by YsaE/SycB and YsrS/YsrR. J. Bacteriol. 2004, 186:4056-4066.
27. Zhou X., Shah D.H., Konkel M.E., Call D.R. Type III secretion system 1 genes in Vibrio parahaemolyticus are positively regulated by ExsA and negatively regulated by ExsD. Mol. Microbiol. 2008, 69:747-764.