Asthma treatment outcome in children is associated with vascular endothelial growth factor A (VEGFA) polymorphisms

Molecular Diagnosis and Therapy

Volumn 16, Issue 3, 2012, Pages 173-180

  Balantic, Mateja ^a   Rijavec, Matija ^a   Skerbinjek Kavalar, Maja ^b   Suskovic, Stanislav ^a   Silar, Mira ^a   Kosnik, Mitja ^a   Korosec, Peter ^a  

^a University Clinic of Pulmonary and Allergic Diseases   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE MARIBOR   (Slovenia)

Author keywords

Asthma; Fluticasone propionate; Genetic polymorphism; Montelukast; Treatment outcome; Vascular endothelial growth factor

Indexed keywords

FLUTICASONE PROPIONATE; MONTELUKAST; VASCULOTROPIN A;

ARTICLE; ASTHMA; BEDTIME DOSAGE; CHILD; CORTICOSTEROID THERAPY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLOVENIA; SYMPTOM; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VEGFA GENE;

ACETATES; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUINOLINES; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 84861660619     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.2165/11631710-000000000-00000     Document Type: Article

References (31)

1. Bousquet J, Jeffery PK, BusseWW,et al. Asthma: From bronchoconstriction to airways inflammation and remodeling.AmJ Respir Crit Care Med 2000; 161: 1720-1745
2. Mauad T, Bel EH, Sterk PJ. Asthma therapy and airway remodeling. J Allergy Clin Immunol 2007; 120: 997-1009
3. Ribatti D, Puxeddu I, Crivellato E, et al. Angiogenesis in asthma. Clin Exp Allergy 2009; 39: 1815-1821
4. Detoraki A, Granata F, Staibano S, et al. Angiogenesis and lymphangiogenesis in bronchial asthma. Allergy 2010; 65: 946-58
5. Bischof RJ, Bourke JE, Hirst SJ, et al. Measurement and impact of remodeling in the lung: Airway neovascularization in asthma. ProcAmThorac Soc 2009; 6: 673-7
6. Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessels formation. Nature 2000; 407: 242-8
7. Lee KS, Kim SR, Park HS, et al. Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression. J Allergy Clin Immunol 2004; 114: 1093-9
8. Lee CG, Link H, Baluk P, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004; 10: 1095-103
9. Kristan SS, Malovrh MM, Silar M, et al. Airway angiogenesis in patients with rhinitis and controlled asthma. Clin Exp Allergy 2009; 39: 354-60
10. Asai K, Kanazawa H, Kamoi H, et al. Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients. Clin Exp Allergy 2003; 33: 595-9
11. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001; 107: 295-301
12. Suzaki Y, Hamada K, Sho M, et al. A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model. Allergy Clin Immunol 2005; 116: 1220-7
13. Park HS, Kim SY, Kim SR, et al. Tarrgeting abnormal airway vascularity as a therapeutical strategy in asthma. Respirology 2010; 15: 459-71
14. Feltis BN, Wignarajah D, Reid DW, et al. Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma. Thorax 2007; 62: 314-9
15. Poulin S, Thompson C, Thivierge M, et al. Cysteinyl-leukotrienes induce vascular endothelial growth factor production in human monocytes and bronchial smooth muscle cells. Clin Exp Allergy 2011; 41: 204-17
16. Kazani S, Wechsler M E, Israel E. The role of pharmacogenomics in improving the management of asthma. J Allergy Clin Immunol 2010; 125: 295-302
17. Ito K, Chung KF, Adcock IM. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2006; 117: 522-43
18. Szalai C, Ungvári I, Pelyhe L, et al. Asthma from a pharmacogenomic point of view. Br J Pharmacol 2008; 153: 1602-1614
19. Ruggiero D, Dalmasso C, Nutile T, et al. Genetics of VEGF serum variation in human isolated populations of Cilento: Importance of VEGF polymorphisms. PLoS One 2011; 6: E16982
20. Sharma S, Murphy AJ, Soto-Quiros ME, et al. Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. Eur Respir J 2009; 33: 1287-1294
21. Robertson CF, Price D, Henry R, et al. Short-course montelukast for intermittent asthma in children: A randomized controlled trial. Am J Respir Crit Care Med 2007; 175: 323-9
22. Horvath G, Wanner A. Inhaled corticosteroids: Effects on the airway vasculature in bronchial asthma. Eur Respir J 2006; 27: 172-87
23. Wang K, Liu CT, Wu YH, et al. Budesonide/formoterol decreases expression of vascular endothelial growth factor (VEGF) and VEGF receptor 1 within airway remodelling in asthma. Adv Ther 2008; 25: 342-54
24. Zanini A, Chetta A, Imperatori AS, et al. The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. Respir Res 2010; 11: 132
25. Greenberger PA. Personalized medicine for patients with asthma. J Allergy Clin Immunol 2010; 125: 305-6
26. Abdel-Rahman AM, el-Sahrigy SA, Bakr SI. A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Chest 2006; 129: 266-71
27. Johnson AD, Handsaker RE, Pulit SL, et al. SNAP: A web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008; 24: 2938-9
28. Tantisira KG, Lake S, Silverman ES, et al. Corticosteroid pharmacogenetics: Association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet 2004; 13: 1353-9
29. Tantisira KG, Small KM, Litonjua AA, et al. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: Interaction between beta-Agonist and corticosteroid pathways. Hum Mol Genet 2005; 14: 1671-7
30. Nauck M, Karakiulakis G, Perruchoud AP, et al. Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells. Eur J Pharmacol 1998; 12: 309-15
31. Rothenberg ME. VEGF obstructs the lungs. Nat Med 2004; 10: 1041-2